Pattern Of Dyslipidemia In Patients Research Articles

Evaluation of lipid profile in systemic lupus erythematosus and relation with interleukin-10

Objectives: To detect pattern of dyslipidemia in patients of SLE and clarify the correlation between lipid profile with disease activity, inflammatory factors, and cytokines. Materials and Methods: Blood collected from 65 SLE patients and 30 healthy controls measured Th-17, IL-17, IL-10 by flow cytometer. Statistical analysis: The relationship of lipid profile with various parameters was analyzed and stepwise logistic regression was used to assess the predictors of dyslipidemia. Results: The unique pattern of dyslipidemia in high disease activity was a significant decline in high density lipoprotein (HDL) and apolipoprotein A1 when compared to low disease activity. IL-10 was the strongest predictor for HDL (CI: -0.31 to -0.20, p=0.000). This is the first time a relation of IL-10 with HDL has been determined in SLE patients. Conclusion: IL-10 elevation is associated with decline in HDL. Since IL-10 appears to be a potential modulator of dyslipidemia in SLE, it can serve a new target for lipid metabolism to reduce cardiovascular risk in SLE.

Prevalence of different patterns of dyslipidemia in patients with type 2 diabetes in an Iranian population

BackgroundDiabetic dyslipidemia is a complex multidimensional abnormality. However, earlier studies did not focus on the prevalence of various patterns of dyslipidemia. We categorized dyslipidemia into three groups. Single dyslipidemia (7 patterns) and mixed dyslipidemia consisted of dual (16 patterns) and triple (4 patterns) combinations of different patterns of single dyslipidemia.MethodsThis cross-sectional study included 2097 patients with type 2 diabetes (T2D) between 2014 and 2021. We measured blood lipid profile parameters and calculated the atherogenic index of plasma (AIP) using log (TG/HDL-C). We analyzed dyslipidemia as a categorical variable and expressed results as numbers and percentages. We used Chi-square or Fisher exact tests to compare categorical variables.ResultsA total of 97.81% of patients had at least one lipid abnormality. High AIP (88.0%) was the most common pattern, followed by LDL-C ≥ 70mg/dl (80.1%), and low HDL-C (58.0%). 73.87% of patients had mixed dyslipidemia. The dual combination of high AIP and LDL-C ≥ 70mg/dl was the most common pattern of mixed dyslipidemia (71.1%). Additionally, 24.7% of patients had triple combination dyslipidemia. All dyslipidemia patterns were more common among women than men, except for high AIP. In patients with T2D and coronary artery disease (CAD) history, high AIP was the most prevalent pattern of dyslipidemia (87.5%), followed by LDL ≥ 70mg/dl (68.6%). Also, the dual combination of high AIP and LDL ≥ 70mg/dl was the most common pattern of mixed dyslipidemia in patients with T2D and CAD history (60.67%).ConclusionThis study showed that single and mixed (dual and triple combination) dyslipidemia is common among patients with T2D. High AIP and LDL-C ≥ 70mg/dl were the most common patterns, either single or combined, in patients with or without CAD.

The frequency and pattern of deranged lipid profile in patients with ischemic stroke: a retrospective study.

Background and aim:Ischemic Stroke has been recognized as the principal cause of disability and the third leading cause of mortality worldwide. The aim of this study was to determine the frequency and pattern of dyslipidemia in patients presenting with ischemic stroke at a tertiary care hospital in Karachi, Pakistan and to evaluate the effect of demographic and clinical factors on the frequency and pattern of dyslipidemia in ischemic stroke subjects.Methods:A cross-sectional study carried on a sample size of 235 patients presenting to the out-patient clinic with paralysis, difficulty in speech, and/or loss of consciousness lasting for one hour or more. Blood samples were analyzed for total cholesterol (TC), triglycerides (TG), low-density lipoproteins (LDL), very low-density lipoproteins (VLDL) and high-density lipoproteins (HDL) by the enzymatic colorimetric methodology. These values were recorded on the pre-defined proforma by the investigators. All analysis was performed using SPSS version 23.0.Results:The average age of the patients was 50.84±11.51 years and 62.1% of them were males. The frequency of dyslipidemia was observed in more than half (n=134/235, 57.02%) of ischemic stroke patients. Regarding the dyslipidemia pattern, TC, VLDL-C and TG levels were deranged in more than 50% of the cases. The most commonly deranged values were of TC and VLDL-C, followed by TG levels. It was observed that patients with a previous history of DM (73.9%, p=0.002) and HTN (81.3%, p=0.001) had significantly higher rates of deranged lipid profiles. Lipid values were found to be more deranged in patients aged 41-50 years (p=0.002) however, no statistically significant differences were observed with respect to BMI (p=0.192) and symptoms duration (p=0.334).Conclusions:Dyslipidemia is an important risk factor for ischemic stroke, and elevated LDL-C is usually the lipid fraction implicated in the pathologic mechanism of stroke. (www.actabiomedica.it)

Dyslipidemia in Chronic Kidney Disease

Objective: To determine the frequency for pattern of dyslipidemia in patients with chronic kidney disease. Study Design: Descriptive, cross-sectional Place and Duration of Study: Department of Nephrology, Jinnah Postgraduate Medical Centre (JPMC) from 26th December 2018to 28thJune 2019. Methodology: One hundred and thirty-two patients were enrolled. Blood sample of 5 ml of each patient was taken and sent to the institutional pathology laboratory for measurement of lipid profile and pattern of dyslipidemia i.e. high cholesterol, low HDL, high LDL, hypertriglyceridemia was noted. Results: The mean age was 44.68±9.39 years and mean of duration of chronic kidney disease was 5.13±2.19 months. Seventy eight (59%) were males and 54 (41%) were females. Pattern of dyslipidemia i.e. high cholesterol, low HDL, high LDL and hypertriglyceridemia were documented in 89 (67.4%), 61 (46.2%), 65 (49.2%) and 37 (28.0%) patients respectively. Conclusion: Dyslipidemia is common among patients with chronic kidney disease is considerable. Regular evaluation of all chronic kidney disease patients for dyslipidemia and treatment need to be instituted. Key words: Dyslipidemia, Chronic kidney disease (CKD), Cholesterol, Low density lipoprotein (LDL), High density lipoprotein (HDL), Hypertriglyceridemia

Frequency and pattern of dyslipidemia in diabetes mellitus type 2.

Objective: This study was designed to evaluate the frequency and pattern of dyslipidemia in patients of diabetes mellitus type 2. Study Design: Cross Sectional Observational study. Setting: Medicine Department and National Institute of Diabetes and Endocrinology OPD of Dow University Hospital OJHA Campus Karachi Sindh. Period: March 2018 to September 2018. Material & Methods: 142 diabetes mellitus type 2 patients aged between 35-60 years, selected by non-probability consecutive sampling method. Detailed medical history and blood sample for fasting lipid profile was obtained from each diabetic patient. Result: Out of 142 diabetic patients investigated for dyslipidemia, 72 (50.7%) were male and 70 (49.3%) were female with a mean age of 47.49±6.40 (35-60) years. Dyslipidemia was detected in 114 (80.3%) patients; with most common abnormality was elevated serum triglycerides (54.9%), followed by decreased serum HDL cholesterol (50.7%), elevated serum VLDL cholesterol (50.0%), elevated serum cholesterol (38.7%) and elevated serum LDL cholesterol (16.9%). Conclusion: It was concluded that diabetes mellitus type 2 is directly correlated with higher incidence of dyslipidemia.

Prevalence and pattern of dyslipidemia in patients with type 2 diabetes mellitus in Zaria, Northwestern Nigeria.

IntroductionDyslipidemia confers excess atherosclerotic cardiovascular risk in type 2 diabetes mellitus (DM) patients, and this requires prompt identification and management to reduce morbidity and mortality. This study assessed the prevalence and pattern of dyslipidemia in type 2 DM patients in Zaria, Northwestern Nigeria.MethodsThis was a cross-sectional study of newly diagnosed type 2 DM patients at Ahmadu Bello University Teaching Hospital (ABUTH), Zaria. Demographic, clinical and laboratory data were extracted from the case notes of eligible patients and analyzed using STATA version 14. Continuous variables were presented as mean ± standard deviation (SD), or median and interquartile range (IQR) while categorical variables were as frequencies and percentages. Student t and chi-square tests were used to test for association at p < 0.05.ResultsA total of 322 subjects (161 male, 161 female) with a mean age of 53.5 ± 10.8 years partook in the study. The prevalence of dyslipidemia was 69.3%. Mixed dyslipidemia of high triglyceride (TG) and high low-density lipoprotein cholesterol (LDL-C) was present in 41.0%; high TG and low high-density lipoprotein cholesterol (HDL-C) in 2.8%; and high LDL and low HDL in 2.5%. Atherogenic dyslipidemia, isolated hypercholesterolemia and isolated low HDL-cholesterol were present in 3.4%, 2.5% and 23.6% respectively. Dyslipidemia status was not associated with age, sex, duration of DM or hypertension, obesity, and mean fasting blood sugar (FBS) and 2-hour postprandial glucose.ConclusionThe prevalence of dyslipidemia is high in the newly diagnosed type 2 DM patients and therefore, initial management should incorporate measures to control dyslipidemia.

Lipid Profile of Patients with Thyroid Dysfunction in Ayurveda Hospital

Background : Thyroid hormones play an indispensable role in various metabolic processes in the human body. Thyroid disorders other than iodine deficiency disorders in the form of thyroiditis, hypothyroidism or autoimmune thyroid dysfunctions are on rise. Objective : This study was done to study the prevalence and pattern of dyslipidemia in patients with thyroid dysfunction. Methods : It is a retrospective study based on the available biochemical data of 50 thyroid patients (33 females and 17 males) with age range of 26-68 years. Serum total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), very low density lipoprotein cholesterol (VLDL-C) triiodothyronine (T 3 ), thyroxine (T 4 ) and thyroid stimulating hormone (TSH), were measured using standard assays procedures. Results: The results showed that 82% of the study population has hypothyroidism with the higher prevalence among females. The mean values of T 3 , T 4 and TSH in patients with thyroid dysfunction were 0.8 0.05 ng/ml, 4.2 0.5 mg/dl and 9.45 1.2 mIU/ml, respectively. The mean values of TC, TG, HDL-C, LDL-C, and VLDL-C were 222.4 3.8 mg/dl, 180.3 8.2 mg/dl, 35.6 1.3 mg/dl, 151.6 6.2 mg/dl and 36.5 2.6 mg/dl respectively in patients with hypothyroidism. Hypothyroidism shows significant positive correlation with TC, TG and LDL. Results show that even a slight increase in serum TSH showed significant dyslipidemia. Conclusion : This study suggests that regular monitoring of lipid level in patients with thyroid dysfunction would be helpful in preventing cardiovascular diseases.

PATTERN OF DYSLIPIDEMIA IN PATIENTS WITH CRF

Objectives: (1)To find the pattern of dyslipidemias in patients with CRF.(2.)To compare the results with international studies. Design: Prospective observational study. Setting: In Medical UnitI, II, III and Nephrology ward of Allied Hospital Faisalabad. Period: (06 Months) From: Nov 2004 to April 2005. . AlliedHospital is a teaching hospital attached with Punjab Medical College Faisalabad having 1100 beds. Chronic renalfailure, a very common disease, is accompanied by many complications. One of such complications is abnormality oflipids. The lipids are disturbed in a characteristic manner. This disturbed lipid pattern predisposes the patients toatherosclerotic complications and increased mortality due to cardiovascular and cerebrovascular accidents. Presentstudy was conducted to determine the pattern of dyslipidemias in patients of CRF.50 patients diagnosed to have CRFwere subjected to fasting lipid profile, irrespective of cause and sex. Maximum patients had elevated triglyceride levels(46%). A considerable percentage (16%) had decreased HDL levels and a small percentage had elevated LDL (4%).Total lipids were found to be elevated in 04 patients (8%). All the patients with elevated total lipid were suffering fromdiabetes mellitus. Total cholesterol was elevated in 08 patients (16%). This disturbed lipid pattern has role inatherosclerosis. The patients of CRF who are already having disturbed endothelial function are more prone to it.

Case Study: A Woman With Type 2 Diabetes and Severe Hypertriglyceridemia Sensitive to Fat Restriction

L.S. is a 52-year-old Caucasian woman who was diagnosed with type 2 diabetes in 1988. She developed hypertriglyceridemia 3 years later and hypertension 9 years later. Other medical problems include obesity and diverticulosis. She presents now for screening to determine eligibility for a clinical research protocol using once-daily insulin. Physical exam reveals a height of 64 inches, a weight of 181 lb, a body mass index of 31 kg/m2, and a waist circumference of 40 inches. Blood pressure, well controlled on 20 mg lisinopril (Prinivil) daily, is 104/70 mmHg. Laboratory results reveal a fasting lipid panel as follows: total cholesterol 214 mg/dl, triglycerides 940 mg/dl, direct HDL cholesterol 24 mg/dl, an invalid LDL cholesterol unobtainable because of the hypertriglyceridemia, and a free fatty acid of 1.1 mEq/l (normal range 0.1–0.6 mEq/l). Hemoglobin A1c (A1C) is 9.5%, and fasting blood glucose (FBG) is 304 mg/dl. When called to discuss the finding of severe hypertriglyceridema, the patient commented that she had previously had fasting triglycerides as high as 3,000 mg/dl. L.S. is currently taking metformin (Glucophage), 1,000 mg twice daily, and glipizide (Glucatrol XL), 10 mg twice daily, to control her blood glucose. She is also on gemfibrizol (Lopid), 600 mg twice daily, for hypertriglyceridemia and estradiol (Estraderm) for menopause (topical estrogen does not induce hypertriglyceridemia). 1. What nutritional modification would be effective in rapidly lowering serum triglycerides when the patient is at risk of pancreatitis? 2. What treatment strategies can be employed to lower triglycerides, and how effective are they? 3. How can nutritional modifications improve insulin resistance? Type 2 diabetes carries a two- to fourfold excess risk of coronary heart disease. The most common pattern of dyslipidemia in patients with type 2 diabetes is elevated triglycerides and decreased …