In this study we examined the dermatoglyphic features of 99 Malawian patients with diabetes,hypertension and diabetes with hypertension, attending the outpatient clinic at Lilongwe and QueenElizabeth Central Hospitals. Plantar and digital pattern types were determined and their variabilitywas calculated using Dankmeijer’s (DI) and pattern intensity (PII) indices. The results showed thatthe soles of all patients had more loops than arches and more arches than whorls, which wererestricted to the distal zones. In hypertension, whorls were found in zones I, II and III whereas inpatients with diabetes and hypertension, the whorls were seen in zones I, III and IV. In digits themost predominant ridge pattern were arches in all patients, followed by loops and whorls were absent.In the first digit, diabetic patients had no arches but women hypertensives showed arches. In patientswith diabetes and hypertension, arches were present in both sexes but in men it was confined to theright foot. Loops were only found in the first digit in all patients. The frequency of loops was highestin diabetic patients, high in diabetics with hypertension and least in patients with hypertension alone.Using PII and DI indices, there were significant differences between patients and healthy Malawiansubjects (P < 0.001), and between the sexes (P < 0.01), but PII did not show significant differenceswith sex (P > 0.5) in hypertensives. Diabetic patients had the lowest mean DI when compared to theother groups. In conclusion, this study has demonstrated plantar and digital dermatoglyphicdifferences between patients and healthy Malawians, differences that were exhibited more in digitalthan in plantar ridge patterns. The disease conditions were indicated better by whorls intopographical zones IV of the sole and by the presence and frequency of loops in the first digit.