Dr. Anandibai Joshi was the first Indian female physician to complete her studies in Western medicine at the Women's Medical College of Pennsylvania. A pioneer in medicine, she was a trailblazing Indian woman, who had faced many hurdles during her quest for education. In her short span of life, she faced a lot of emotional, mental, physical, and social turbulence and had to prove herself at every step to the orthodox patriarchal Indian society the need to study medicine. Studying medicine in India was impossible for females during the 19th century. During those days, the females in India were uneducated due to gender differences prevalent in society, so the only option was to pursue medicine in a foreign land. Her life was full of hardships and challenges; she got married at the age of nine and, at the young age of 14, delivered a baby boy who could not survive beyond 10 days due to lack of medical care. This was the turning point in her life, and she was determined to become a physician so that the other women would not suffer the way she had. Thus began her educational journey, to pursue a career in Western medicine. Before Anandibai went to the United States, she gave a motivating speech in a public gathering, expressing the need for female doctors in India and her keenness to pursue medicine in the United States. She challenged all the social norms in those days, whether it was fighting to break gender stereotypes or convincing the male-dominated society to study medicine in the United States. This article is a reflection of Anandibai's accomplishments in her life and medical career and her dedication, determination, and strong commitment to improving the lives of Indian women. Her short life is a reflection of hope, perseverance, determination, and success and an inspiration to many Indian women to pursue education and medicine.