Acute poisoning with various substances is common worldwide. Exposure toagrochemicals, medicines and environmental agents are the major causes of poisoning.1 It isone of the commonest causes of morbidity and mortality to the patients which has drawn theworld attention. Objectives: To determine the socio-demographic characteristics and causesand agents of poisoning among patients visiting emergency department with acute poisoning.Methods: All the poisoning cases that fulfilled the inclusion criteria and attended the emergencydepartment from February 2014 till March 2015 with acute poisoning were evaluated. A hospitalmedical record form were used for data collection in which the details of patient’s demography,agents of poisoning and intension of poisoning, were entered from hospital records andanalyzed. Results: A total of 364 patients attended the emergency department of Zia Uddinuniversity hospital over period of 12 months. In this population 36% were male and 64%were females. Commonest age group for poisoning was 15-30 yrs. and commonest agentwas organophosphate. Intentional poisoning comprised of 88% while accidental poisoningcomprised of 12%. Conclusion: On the basis of our study we can conclude that femaleadolescents and adults are more prone to intentional acute poisoning and pesticides are thecommonest agents involved in acute poisoning.