Polycystic ovary syndrome (PCOS) is one the most common hormonal disorders among women of reproductive age, with an estimated prevalence of 5-10%. PCOS is associated with long-term health risks including infertility, insulin resistance, diabetes, metabolic syndrome, cardiovascular disease, obstructive sleep apnea, endometrial carcinoma, depression and anxiety. Despite an increase in medical literature regarding the association of PCOS with long term health sequelae, there are few published studies that assess the patient's understanding and awareness of these risks. To assess the knowledge and awareness of long term health sequelae of PCOS in women with PCOS seeking tertiary medical support at a reproductive endocrinology and infertility center. Patients with a known diagnosis of PCOS by Rotterdam criteria seeking tertiary medical support at a single reproductive endocrinology and infertility center were recruited for this cross-sectional survey. Fourty-three surveys were completed. Survey questions included demographic information, and assessed knowledge of long term health sequelae associated with polycystic ovary syndrome. The mean age of participants was 27.2 +/- 5.5 years. Participants identified as White/Caucasian (81.4%), Black/African American (11.6%), Hispanic (7.0%), and other (9.3%). 62.8% had a college degree or greater. 33.3% had annual household incomes of < 50,000. The majority of women knew that PCOS was associated with anovulation (88.4%), infertility (88.4%), insulin resistance (79.1%), and anxiety and depression (74.4%). Less than half the women knew PCOS was associated with metabolic syndrome (32.6%), endometrial cancer (34.9%), cardiovascular disease (48.8%), and sleep disorders (25.6%). Among women with PCOS seeking tertiary medical support at a reproductive endocrinology and infertility center, basic knowledge of PCOS is established. However, women with PCOS are less familiar with the full spectrum of long term health consequences of PCOS. Additional research is needed to further assess patient’s knowledge of PCOS and to develop interventions to optimize education and dissemination of information to patients with PCOS.