Nursing is professions that play an role important in maintenance efforts to guard quality service health at home Sick. Service nursing becomes a factor decider of success in service. Remember that the nurse is one of the sources of Power man important at home sick, expected nurses Work with professionals in running work, so produce work satisfaction. Satisfaction Work is what people feel to work or emotions that are natural on-the-spot work, comfort feelings experienced to work. The aim of this study for analyze factor determinant satisfaction Work nurses in the Inpatient ward of Toto Kabila Regional Hospital. The research design uses Analysis observational with approach cross-sectional. A study was done in the month of January 2024 to March 2024 for 125 respondents in nurses Inpatient room at Toto Kabila Hospital. Research results show factor compensation on job satisfaction nurse n value Sig. of 0.002 (< 0.05). Motivational factors on nursing job satisfaction and value Sig. of 0.000 (< 0.05). factor leadership on nurse job satisfaction value Sig. of 0.000 (< 0.05) factor communication on nurses ' job satisfaction and value Sig. of 0.000 (> 0.05). factor supervision of nurses' job satisfaction. Sig value. of 0.000 (> 0.05). So you can conclude that factor compensation, motivation, leadership, communication, and supervision are influential to satisfaction Work nurses in the inpatient ward of Toto Kabila Regional Hospital. Analysis Multivariate variable dominant influence satisfaction Work is variable communication and supervision i. The conclusions of this research state compensation, motivation, leadership, communication, and supervision have significant influence on satisfaction Work nurse in the room take care stay Toto Kabila Regional Hospital. Therefore, hospital management needs to make development efforts to increase nurse job satisfaction.