Patients In Vietnam Research Articles

Characteristics of depressive disorders in patients with rheumatoid arthritis and some related factors.

Rheumatoid arthritis (RA), a type of chronic arthritis, is common in Vietnam. It has severe consequences for patients, both physically and psychologically, including depressive disorders. Therefore, early detection of depressive disorders is of high importance to help provide comprehensive treatment and improve RA patients' quality of life. This cross-sectional study explored the prevalence of depressive disorders and their salient characteristics and related factors in RA patients in Vietnam. We enrolled 156 patients diagnosed with RA using the ACR-1987 criteria. The Patient Health Questionnaire-9 (PHQ-9) was used to screen for depressive disorders. Patients' demographic characteristics and clinical and laboratory investigation results, such as the visual analog score, complete blood count, erythrocyte sedimentation rate, Disease Activity Score 28 for RA with C-reactive protein (DAS28-CRP), and quality-of-life score (based on the SF-36 test) were analyzed. Depressive disorders assessed on the first day of admission were reevaluated by a psychiatrist if the PHQ-9 score was ≥ 5. According to the PHQ-9 results, depression prevalence among RA patients was 76.3%. The majority of patients (49.4%) had moderate-to-severe depression and 91% experienced sleep disorder symptoms. Negative thoughts -- suicidal ideation or self-injury - were reported by 21.8% of patients. Depression severity had a moderately positive relationship with disease activity level and a moderately negative relationship with quality of life. Depression prevalence was high among RA patients. Depression severity increased with disease activity and decreased quality of life.

The annual economic burden incurred by heart failure patients in Vietnam: a retrospective analysis.

Heart failure (HF) is a chronic condition associated with substantial mortality and hospitalisation, resulting in costly inpatient visits. The healthcare systems of several countries, including Vietnam, experience considerable difficulty in dealing with the enormous fiscal burden presented by HF. This study aims to analyse the direct medical costs associated with HF inpatient treatment from the hospital perspective. This study retrospectively analysed the electronic medical records of patients diagnosed with HF from 2018 to 2021 at Military Hospital 175 in Vietnam. The sample consisted of 906 hospitalised patients (mean age: 71.2 ± 14.1 years). The financial impact of HF was assessed by examining the direct medical expenses incurred by the healthcare system, and the costs of pharmaceutical categories used in treatment were explored. The cumulative economic burden of HF from 2018 to 2021 was US$1,068,870, with annual costs ranging from US$201,670 to US$443,831. Health insurance covered 72.7% of these costs. Medications and infusions, and medical supplies accounted for the largest expenses, at 29.8% and 22.1%, respectively. The medication HF group accounted for 13.01% of these expenses, of which the costliest medications included nitrates (2.57%), angiotensin II receptor blockers (0.51%), ivabradine (0.39%), diuretics (0.24%), and mineralocorticoid receptor antagonists (0.23%). Comorbidities and the length of hospital stay significantly influenced annual treatment costs. The study reveals that HF significantly impacts Vietnam's healthcare system and citizens, requiring a comprehensive understanding of its financial implications and efficient management of medical resources for those diagnosed. This study highlights the substantial economic burden of HF on Vietnam's healthcare system, with medication costs, particularly antithrombotic drugs, representing the largest expense. Most healthcare costs were covered by health insurance, and expenses were significantly influenced by comorbidity and length of hospital stay. These findings can inform healthcare policy, resource allocation and optimise management strategies in Vietnam.

Factors related to depression in non-small-cell lung cancer patients treated at K Hospital during 2021 - 2022

Non-small cell lung cancer is currently the second most common cancer when assessing common cancer and the number of cancer deaths; there are a limited number of studies about depression in lung cancer patients in Vietnam. This cross -sectional descriptive study aimed to describe depression in non-small cell lung cancer patients treated at K Hospital from 2021 – 2022 and associated factors. The study was conducted on 243 NSCLC patients treated at K Tan Trieu Hospital by direct phone call interview and psychiatric clinical examination. We applied the PHQ-9 scale and DSM-5 for screening and confirmed depression, and the SF-12 scale was applied for quality of life measurement. The study found that stage IV disease increased the risk of depression more than 6 times in lung cancer patients (OR = 6.47; p<0.05) and patients with poor QoL in the depression group, in which quality of life of mental health (36.94 ± 5.43) and physical health (41.78 ± 7.17) were all lower than those in the group without depression. Measures to monitor mental health, screen for early detection and treatment interventions, and improve quality of life are the top priorities to reduce the risk of depression in patients with non-small cell lung cancer.

Anxiety and depression in palliative care cancer patients in Vietnam: baseline data from a randomized controlled trial of multidisciplinary palliative care versus standard care

Anxiety and depression in palliative care cancer patients in Vietnam: baseline data from a randomized controlled trial of multidisciplinary palliative care versus standard care

Prevalence and drug susceptibility of clinical Candida species in nasopharyngeal cancer patients in Vietnam

In the nature, Candida species are normal inhabitants and can be observed in a wide variety of vertebrates. In humans, especially for cancer patients who fall prey to opportunistic pathogens, this group of susceptible multi-drug resistant and biofilm-forming yeasts, are among the commonest ones. In this study, Candida species in 76 oral lesion samples from Vietnamese nasopharyngeal-cancer patients were isolated, morphologically identified using CHROMagar™, germ tube formation, and chlamydospore formation tests, and molecularly confirmed by PCR-RFLP. The drug susceptibility of these isolates was then tested, and the gene ERG11 was DNA sequenced to investigate the mechanism of resistance.The results showed that Candida albicans remained the most prevalent species (63.16% of the cases), followed by Candida glabrata, Candida tropicalis, and Candida krusei. The rates of resistance of non-albicans Candida for tested drugs were 85.71%, 53.57%, and 57.14% to fluconazole, clotrimazole, and miconazole, respectively. Although the drug-resistance rate of Candida albicans was lower than that of non-albicans Candida, it was higher than expected, suggesting an emerging drug-resistance phenomenon. Furthermore, ERG11 DNA sequencing revealed different mutations (especially K128T), implying the presence of multiple resistance mechanisms. Altogether, the results indicate an alarming drug-resistance situation in Candida species in Vietnamese cancer patients and emphasize the importance of species identification and their drug susceptibility prior to treatment.

Study on prognostic index for survival m-LCPI in patients with primary non-small cell lung cancer

Background: Lung cancer is a common cancer with a high mortality rate. The identification of prognostic factors in lung cancer patients in Vietnam is still limited and inconsistent in clinical practice. Objectives: To describe the clinical, paraclinical characteristics and m-LCPI index in patients with primary non-small cell lung cancer and evaluate the factors affecting overall survival in patients with primary non-small cell lung cancer. Methods: Prospective study of 210 cases of non-small cell lung cancer diagnosed with primary non-small cell lung cancer at the Oncology Department of Hue University of Medicine and Pharmacy Hospital and Hue Central Hospital from February 2020 to February 2023. Results: The majority of hospitalizations were at late stages, from stage IIIA (89%), group 3 and 4 in m-LCPI grading scale constituted the majority (80%). Average overall survival at 3 years was 20.0 ± 14 months, and gradually decreased to 54.8%, 40%, and 38.6% after 1 year, 2 years and 3 years, respectively. Regression analysis of COX model between m-LCPI and OS showed statistical significance with m-LCPI 4 (HR = 3.9, 95%CI = 1.57 - 9.69, p = 0.003), while m-LCPI 3 (HR = 2.44, 95% CI 0.97 - 6.13), p = 0.058) had a weak correlation. Conclusion: Our study shows that 38.6% of patients were still alive after 3 years of diagnosis. m-LCPI index is a good predictor of the patients’ overall survival. Key words: non-small cell lung cancer, overall survival, prognostic index, mLCPI.

Avoidance of healthcare service use and correlates among HIV-positive patients in Vietnam: a cross-sectional study

ObjectiveThe prevention of HIV/AIDS is not making sufficient progress. The slow reduction of HIV/AIDS infections needs to prioritise hesitancy towards service utilisation, including treatment duration, social support and social stigma....

2108. In-vitro Activity of Five Novel Anti-Fungal Compounds Against Thirty-Two Strains of Talaromyces marneffei

Abstract Background Talaromyces marneffei (Tm) is a thermally dimorphic fungus causing invasive mycosis in human immunodeficiency virus (HIV) infected patients in Southeast Asia and is a leading cause of AIDS-related deaths in this region with mortality on anti-fungal therapy as high as 30%. The limited options, routes of administration, and toxicity of antifungals with established efficacy against Tm calls for assessment of efficacy for additional antifungals against Tm. Here we evaluate the in-vitro efficacy of 5 novel anti-fungal agents against 32 clinical strains of Tm. The agents tested include ibrexafungerp, two manogepix compounds (APX001A and APX2039), olorofim, and oteseconazole. Methods 32 Tm isolates were cultured from clinical samples from patients in Vietnam and identified as Tm by standard morphological characteristics. Inocula were prepared from these clinical samples in conjunction with CLSI standards and plated onto 96-well microplates. Concentrations for each drug ranged from 0.008 µg/mL to 4 µg/mL. AlamarBlueTM, a resazurin-based cell viability indicator dye, was added to the drug-inoculum solution. Use of this reagent enabled utilization of a microplate fluorescence intensity(FI) reader to objectively identify the designated MIC endpoint of 50% inhibition of growth. Methods (Figure 1). MIC endpoint determination using AlamarBlue indicator dye method. Clinical Tm isolates were thawed and plated on Yeast Peptone Dextrose (YPD) agar and grown for 3-5 days at 37°C. Isolates were then sub-cultured on fresh YPD agar and allowed to grow for 3 days prior to inoculum preparation. Inocula were prepared according to CLSI standards. Following suspension in solution, inocula were diluted in PBS until an optical density (OD) of 0.5 to 0.6 was achieved. Inocula were further diluted in RPMI + MOPS and added to the drug-dilution microplates to achieve a final concentration of 1000-5000 cells/mL. After incubation at 37°C for 24 hours, AlamarBlue was added to all wells. Following incubation for an additional 48 hours, fluorescence intensity (FI) was measured using a microplate reader to determine the MIC endpoint of 50% inhibition of fungal growth. Results Of the drugs tested, olorofim showed the highest activity against the 32 isolates, with MICs consistently ≤ 0.008 µg/mL. This was followed by oteseconazole with MICs between ≤ 0.008 and 0.031 µg/mL APX001A with MICs between 0.031 and 0.25 µg/mL and APX2039 with MICs between 0.25 and 4 µg/mL. Ibrexafungerp had the broadest MIC distribution with MICs between 0.063 and 4 µg/mL. Figure 2/Table 1. MIC Endpoint Distribution. Figure 2 shows a scatter plot of MIC endpoints for each drug. Error bars demonstrate the geometric mean and 95% confidence intervals. Table 1 illustrates the MIC endpoint distribution in a graded heat map format. In addition, the absolute values of the geometric mean (GM), mode, MIC50, and MIC90 are displayed at the right side of the table. Both Figure 2 and Table 1 illustrate high efficacy for olorofim and oteseconazole, with low MIC endpoints consistent across the 32 isolates. The manogepix compounds(APX001A and APX2039) demonstrate surprisingly contrasted performance against Tm, despite the similar chemical structure and identical mechanism of action of the drugs. APX001A had significantly lower MIC endpoints compared to APX2039. Ibrexafungerp had the broadest range of MIC endpoints from 0.063 to 4µg/mL and the highest MIC50 and MIC90 of all the drugs. However, a significant proportion of isolates were highly susceptible to the drug. Conclusion In-vitro activity of the 5 drugs tested against the 32 Tm strains was variable, but all should be considered potential candidates for treating Tm infection. To further evaluate the potential role of each drug in treating Tm infection, the next step should be to evaluate each in in-vivo models. Disclosures All Authors: No reported disclosures

Severity and Factors Associated with Depressive Symptoms Among Type 2 Diabetic Patients in Vietnam.

Diabetes and psychiatric disorders often co-occur. The prevalence of depression in a person with diabetes is two times higher than that of the general population. During the last decade, the prevalence of diabetes in Vietnam has nearly doubled. However, there is little data regarding depressive symptoms among people with diabetes. Therefore, this study aims to explore the level of depressive symptoms and its associated factors among patients with type 2 diabetes mellitus in Hanoi, Vietnam. A cross-sectional study was conducted among 519 patients diagnosed with type 2 diabetes at the Agricultural General Hospital, one of the largest primary care hospitals for diabetes in Hanoi, Vietnam. Patient Health Questionnaire-9 (PHQ-9) was used to assess the severity of depressive symptoms. Multivariate Tobit and logistic regression models were applied to examine factors associated with the severity of depressive symptoms and medication adherence. Approximately 45.2% of participants were identified as having depressive symptoms at different levels. The proportion of patients with mild, moderate, moderately severe, and severe depressive symptoms is 36.0%, 7.6%, 1.4%, and 0.2% respectively. Regarding the treatment process, patients being treated for their diabetes for a longer time were more likely to have depressive symptoms. Depression was positively linked to currently drinking alcohol (Coef = 1.04; 95% CI = 0.30-1.78), having comorbidities (Coef = 1.08; 95% CI = 0.15; 2.01) and having irregular physical activities (Coef = -1.28; 95% CI = -2.18; -0.38). Patients with severe depressive symptoms (higher PHQ-9 score) were more likely to be non-adherent to their medications in the last month (AOR = 1.30; 95% CI = 1.17; 1.46). Our study shows that a high percentage of patients with diabetes have depressive symptoms. There is a strong association between having depressive symptoms and non-adherence to medications in the last month. To reduce the risk of developing depressive symptoms, depression should be screened at the initial treatment process and patients should be advised to avoid alcohol and to engage in physical activities regularly.

9P Clinicopathological features and prognosis of mucinous breast cancer: A retrospective analysis of 358 patients in Vietnam

9P Clinicopathological features and prognosis of mucinous breast cancer: A retrospective analysis of 358 patients in Vietnam

Serological and Molecular Epidemiology of Chikungunya Virus Infection in Vietnam, 2017-2019.

Chikungunya fever is an acute febrile illness caused by the chikungunya virus (CHIKV), which is transmitted by Aedes mosquitoes. Since 1965, only a few studies with limited scope have been conducted on CHIKV in Vietnam. Thus, this study aimed to determine the seroprevalence and molecular epidemiology of CHIKV infection among febrile patients in Vietnam from 2017 to 2019. A total of 1063 serum samples from 31 provinces were collected and tested for anti-CHIKV IgM and IgG ELISA. The 50% focus reduction neutralization test (FRNT50) was used to confirm CHIKV-neutralizing antibodies. Quantitative real-time RT-PCR (RT-qPCR) was performed to confirm the presence of the CHIKV genome. The results showed that 15.9% (169/1063) of the patients had anti-CHIKV IgM antibodies, 20.1% (214/1063) had anti-CHIKV IgG antibodies, 10.4% (111/1063) had CHIKV-neutralizing antibodies, and 27.7% (130/469) of the samples were positive in RT-qPCR analysis. The E1 CHIKV genome sequences were detected among the positive RT-qPCR samples. Our identified sequences belonged to the East/Central/South/African (ECSA) genotype, which has been prevalent in Vietnam previously, suggesting CHIKV has been maintained and is endemic in Vietnam. This study demonstrates a high prevalence of CHIKV infection in Vietnam and calls for an annual surveillance program to understand its impact.

Acute invasive fungal rhinosinusitis in post-COVID-19 patients in Vietnam

Acute invasive fungal rhinosinusitis (AIFR) is a potentially lethal infection commonly found in immunocompromised patients. It is considered the most aggressive subtype of fungal sinusitis and can lead to severe morbidity and mortality. There was a significant increase in the incidence of AIFR in post-COVID-19 patients compared to AIFR cases before the COVID-19 pandemic. This study aimed to describe the clinical presentation of AIFR associated with COVID-19 illness. A retrospective study included 22 patients diagnosed with AIFR with a recent COVID-19 infection. The most frequent disease associated with AIFR was diabetes mellitus (95.5%). The mycological analysis identified infection caused by Aspergillus species in 72.7% of patients. Along with stabilizing hemodynamic parameters and controlling any comorbidities, all patients in the present study underwent combined surgical debridement followed by antifungal medications. The overall survival rate was 72.7%. The chance of developing a fatal outcome was significantly higher if meningitis presented initially (odds ratio 35.63, p<0.05). The presence of meningitis upon initial diagnosis is related to a significantly higher chance of developing a fatal outcome and should be considered, especially in AIFR patients previously treated for COVID-19 infections. Early diagnosis, early use of antifungal agents, aggressive surgical debridement, and control of comorbid conditions remain crucial in managing AIFR.

Some Factors Related to Depression in Non-Small-Cell Lung Cancer Patients Treated at K Hospital During 2021 – 2022

Background Understanding lung cancer is currently the second most common cancer when assessing common cancer and the number of cancer deaths; there are a limited number of studies about depression in lung cancer patients in Vietnam. Objective This study aimed to describe depression in non-small cell lung cancer patients treated at K Hospital from 2021 – 2022 and associated factors. Methods Cross-sectional descriptive study. The study was conducted on 243 NSCLC patients treated at K Tan Trieu Hospital by direct phone call interview and psychiatric clinical examination. We applied the PHQ-9 scale and DSM-5 for screening and confirmed depression, and the SF-12 scale was applied for quality of life measurement. Results The study found that the risk factors related to depression included stage IV disease increasing the risk of depression more than 6 times in lung cancer patients (OR = 6.47; p&lt;0.05) and patients with poor QoL in the depression group, in which quality of life of mental health (36.94 ± 5.43) and physical health (41.78 ± 7.17) were all lower than those in the group without depression. Conclusions Measures to monitor mental health, screen for early detection and treatment interventions, and improve quality of life are the top priorities to reduce the risk of depression in patients with non-small cell lung cancer.

Integrated Hospital- and Home-Based Palliative Care for Cancer Patients in Vietnam: People-Centered Outcomes.

Hospital-based palliative care (PC) linked to palliative home care is rarely accessible in low- and middle-income countries (LMICs). To study people-centered outcomes of a palliative home care team based at a major cancer center in Vietnam. The palliative home care team, consisting of at least one physician and one nurse, provided home PC when needed by patients of the cancer center who lived within 10 kilometers. A linguistically validated version of the African Palliative Outcomes Scale was integrated into standard clinical data collection. We retrospectively reviewed data from the 81 consecutive patients on prevalence and severity of pain and other types of physical, psycho-social, and spiritual suffering at the first home visit (baseline) and at the first follow-up visit and measured any differences. There was great demand for palliative home care. From baseline to follow-up, there was significant improvement in pain regardless of the baseline severity of pain (p < 0.003). Among patients with severe pain, breathlessness, nausea/vomiting, diarrhea, depression, or worry about illness at baseline, there was significant improvement (p < 0.001), and caregiver worry about the patient also improved significantly. Integration of hospital- and home-based PC for cancer patients is feasible and improves people-centered outcomes at low cost in Vietnam. These data suggest that benefits to patients, their families, and the health care system can accrue from integration of PC at all levels in Vietnam and other LMICs.

Misusing Elastics for Midline Diastema Closure - Disaster and Treatment Via a Case Report in Vietnam

Midline diastema has been a popular aesthetic problem for children. Several treatment options are available, however, the use of elastic bands without other appliances for closing the diastema still remains a pressing issue in Vietnam, which could be done by the patient’s parents either themselves or under the dental practitioners’ suggestion. Objective: To report a specific case about the extensive extrusion regarding upper central incisors in a pediatric patient due to misusing the elastic band, in which management was complex due to an unfavorable situation for splinting. Case Report: Single rubber band usage for orthodontic movement in closing diastema has been an unresolved disaster in Vietnam, leading to the need for early diagnosis and immediate intervention when facing the complications. Conclusion: Significant information dissemination is paramount for long-term improvement in the oral health of pediatric patients in Vietnam and around the world.

Using ADAPT-ITT framework to tailor evidence-based interventions for addressing methamphetamine use among methadone patients in Vietnam.

Methamphetamine use threatens positive treatment outcomes in substance use and HIV, for people with opioid use disorders (POUD) in many countries. This paper describes the adaptation of four evidence-based interventions (EBI) (motivational interviewing, contingency management, Matrix group model and SMS text messaging) for treating methamphetamine use among POUD receiving methadone maintenance therapy in Vietnam. Following the ADAPT-ITT (Assessment-Decision-Administration-Production-Topical experts-Training-Testing) framework, we conducted 16 focus group discussions with POUD (n = 25) and providers (n = 22) at four methadone clinics in two largest cities (Hanoi in the North, Ho Chi Minh City in the South) to assess patterns of methamphetamine use and to get feedback on proposed EBIs. The proposed EBIs were properly adapted and used to train providers in two of the four methadone clinics. The revised EBIs were tested over 12 weeks among 42 POUD on methadone who use methamphetamine. Post-intervention feedback served to fine-tune the revised EBIs. Insights about patterns of methamphetamine use suggested that EBIs should focus on different triggers to methamphetamine use among POUD receiving methadone treatment in the two cities. All EBIs should emphasise family-related topics to build a strong motivation for treatment. Participants suggested when, where and how each EBI should be delivered. Most participants were satisfied with the adapted EBIs. Limited human resources at methadone clinics might hinder implementation of the adapted EBIs. We successfully completed the adaptation of EBIs for POUD who use methamphetamine on methadone in Vietnam. The pilot testing of the adapted EBIs demonstrated feasibility and acceptability. NCT04706624. Registered 13 January 2021. https://clinicaltrials.gov/ct2/show/NCT04706624.

Clinical validation of a ctDNA-based assay for multi-cancer detection: An interim report from a Vietnamese longitudinal prospective cohort study of 2795 participants.

135 Background: Cancer is a major public health and economic issue and is the leading cause of death worldwide. Up to 80% of cancer patients in Vietnam were diagnosed at stage III or stage IV, leading to a a low 5-year survival rate compared to other countries. Early cancer screening assays capable of identifying early-stage cancer patients among high-risk or asymptomatic individuals are essential to achieve better treatment outcomes and reduced mortality. We previously developed a multimodal LB-based assay named Screening for the Presence Of Tumor by Methylation And Size (SPOT-MAS) to detect the five most common cancer types in Vietnam (liver, breast, colorectal, gastric, and lung cancer). To be successfully applied as a population-wide screening test, the clinical performance of SPOT-MAS needs to be validated in a prospective study. Methods: Herein, we launched a prospective cohort study named K-DETEK (ClinicalTrials.gov identifier: NCT05227261) at 13 major hospitals and one research institute in Vietnam to assess the feasibility and performance of SPOT-MAS in a multi-center clinical trial setting. Our study recruited 10,000 asymptomatic participants participants aged 40 years or older and followed-up for 6 and 12 months. The performance was assessed by computing the number of cases with the detection of a signal (n, %), including a positive predictive value (PPV) and accuracy in detecting tumor tissue-of-origin (TOO). Results: At the time of abstract submission, our analysis of 2795 participants demonstrated its ability to detect cancers in asymptomatic individuals with a positive predictive value of 60%, with 83.3% accuracy in detecting tumor location. Furthermore, we presented a case report to support further using SPOT-MAS as a complementary method to achieve early cancer detection and provide the opportunity for early treatment. Conclusions: Our study has demonstrated the clinical application of a multi-cancer blood test in a low- and middle-income country like Vietnam, where a nationwide cancer screening program is urgently needed but currently not available. Beyond detecting cancer signals, our test predicted the tumor location, allowing clinicians to fast-track the follow-up diagnostic and guide any necessary treatment. Keywords: liquid biopsy, ctDNA, clinical validation, prospective trial, cancer screening. Clinical trial information: NCT05227261 .

Determinants of health-related quality of life among patients with systemic lupus erythematosus in Hanoi, Vietnam

BackgroundSystemic lupus erythematosus (SLE) is a chronic autoimmune disease which impacts patients’ lives. Many studies in high-income countries have focused on their health-related quality of life (HRQoL). However, evidence of awareness of SLE and HRQoL in low- and middle-income countries is lacking. Therefore, this study aimed to identify the determinants of HRQoL of SLE patients in Vietnam, a lower-middle income country.MethodsThis cross-sectional study was conducted at the National Hospital of Dermatology and Venereology in 2019. A pre-tested structured questionnaire was used to collect data. It consisted of Short Form-36 to assess HRQoL which comprised physical and mental component summaries, Multidimensional Scale of Perceived Social Support, Satisfaction with Life Scale, and Mental Adjustment to SLE. Multiple linear regression was used to identify the determinants of HRQoL.ResultsOne hundred thirty four patients with SLE participated in this study. The majority of the patients were women (n = 126, 94.0%). The mean age of all participants was 37.9 years old (standard deviation [SD] 12.5). Of 134 participants, 104 (77.6%) were married. Older patients were more likely to have a lower score of mental component summary (B=-0.45, 95% CI -0.73, -0.17). Patients with more children were more likely to have a lower score of physical component summary (B=-5.14, 95% CI -9.27, -1.00). Patients who felt more helplessness or hopelessness were more likely to have lower scores of physical and mental component summaries (B=-1.85, 95% CI -2.80, -0.90; B=-1.69, 95% CI -2.57, -0.81). Also, patients who felt more anxious were more likely to have a lower score of mental component summary (B=-1.04, 95% CI -1.77, -0.32). Patients who were more satisfied with their lives were more likely to have higher scores of physical and mental component summaries (B = 1.07, 95% CI 0.50, 1.64; B = 1.08, 95% CI 0.55, 1.61).ConclusionFactors associated with lower HRQoL in Vietnam were feelings of helplessness or hopelessness, and burdens of parenting roles. However, social support can contribute to a higher HRQoL, such as information support, self-support groups, and daycare services provided at the community level.

Prevalence and predictors of depression, anxiety, and stress among recovered COVID-19 patients in Vietnam.

During the COVID-19 pandemic, a high prevalence of mental health distress has been reported among people who have recovered from the disease. To assess the prevalence of depression, anxiety, and stress as well as identify predictors among recovered COVID-19 patients after more than six months of being discharged in Dong Thap Province, Vietnam. The cross-sectional study was conducted among 549 eligible participants recruited by stratified sampling. Data was collected using the depression, anxiety and stress scale - 21 items had Content Validity Index = 0.9, and Cronbach's alpha for depression, anxiety and stress sub-scales were 0.95, 0.81, and 0.86, respectively. Descriptive statistics were used to measure the prevalence levels and distribution of characteristics of the participant, while factors influencing depression, anxiety, and stress were predicted using binary logistic regression. The overall prevalence of depression, anxiety, and stress were 24.8% (95% CI: 21.2-28.6), 41.5% (95% CI: 37.4-45.8), and 25.3% (95% CI: 21.7-29.2), respectively. The predictors of depression were living in urban area (OR = 1.97; 95% CI: 1.27-3.08), holding a bachelor's degree (OR:3.51; 95% CI: 1.13-10.8), having a high monthly income (OR: 2.57; 95% CI: 1.03-6.38), diabetes (OR: 2.21; 95% CI: 1.04-4.68), heart disease (OR: 3.83; 95% CI: 1.79-8.17), respiratory disease (OR: 3.49; 95% CI: 1.24-9.84), and diarrhea (OR: 4.07; 95% CI: 1.06-15.6). Living in the urban area (OR: 1.57; 95% CI: 1.07-2.29), having sleep disturbance (OR: 2.32; 95% CI: 1.56-3.46), and fatigue (OR: 1.57; 95% CI: 1.03-2.39) were predictors for anxiety. Having respiratory disease (OR: 3.75; 95% CI: 1.47-9.60) or diarrhea (OR: 4.34; 95% CI: 1.18-15.9) were predictors of stress. People who have recovered from COVID-19 should be assessed for symptoms of depression, anxiety, and stress. Primary healthcare providers should develop interventions to support their recovery.

CD81 and Its Relationship to Treatment Response in Patients With Acute Myeloid Leukemia at a Hospital in Hanoi, Vietnam.

Acute myeloid leukemia (AML) has the proliferation of poorly differentiated immature myeloid cells. New studies on immune markers also consider them as one of the factors that affect the prognosis or the patient's ability to respond to drugs. Our study was designed to determine the rate of remission and mortality, and the ability to respond to drugs in newly diagnosed AML patients withpositive CD81. A total of 50 patients diagnosed with AML (excluding acute promyelocytic leukemia) underwent immunophenotyping analysis using flow cytometry. Following the initial diagnosis, the patients received induction therapy, followed by three cycles of consolidation therapy. The patients were then followed up for a period of six months. The treatment efficacy was assessed at two timepoints: on day 28 after the first chemotherapy course and on day 28 after the fourth chemotherapy course. Out of the 50 newly diagnosed AML patients, 40 (80%) were found to be CD81 positive. This CD81-positive group had a high mortality rate after the first course of chemotherapy (17.5%)and after the fourth course of chemotherapy(52.5%), while no patients died in the CD81-negative group. The CD81-positive group had a worse drug response rate with 22.5% and 18.2% in CD81 positive group versus 30% and 40% in the CD81-negative group achieving complete remission after the first course and fourth course, respectively. The CD81 immunological marker was found to be highly prevalent among AML patients in Vietnam. Overexpression of CD81 in patients with AML is associated with an unfavorable prognosis, characterized by higher mortality rates and poorer treatment response.