Blood Chemistry Of Patients Research Articles

US Attenuation Imaging for the Evaluation and Diagnosis of Fatty Liver Disease.

This study aimed to determine whether the attenuation coefficient (AC) from attenuation imaging (ATI) was correlated with visual US assessment in patients with hepatic steatosis. Moreover, it aimed to assess whether the patient's blood chemistry results and CT attenuation were correlated with AC. Patients who underwent abdominal US with ATI between April 2018 and December 2018 were included in this study. Patients with chronic liver disease or cirrhosis were excluded. The correlation between AC and other parameters, such as visual US assessment, blood chemistry results, liver attenuation, and liver-to-spleen (L/S) ratio, were analyzed. AC values according to visual US assessment grades were compared using analysis of variance. A total of 161 patients were included in this study. The correlation coefficient between US assessment and AC was 0.814 (p < 0.001). The mean AC values for the normal, mild, moderate, and severe grades were 0.56, 0.66, 0.74, and 0.85, respectively (p < 0.001). Alanine aminotransferase levels were significantly correlated with AC (r = 0.317, p < 0.001). The correlation coefficients between liver attenuation and AC and between L/S ratio and AC were -0.702 and -0.626, respectively (p < 0.001). Visual US assessment and AC showed a strong positive correlation with the discriminative value between the groups. Computed tomography attenuation and AC showed a strong negative correlation.

Personalized Nutritional Therapy Based on Blood Data Analysis for Malaise Patients.

As medical doctors, we routinely check patient blood chemistry and CBC data to diagnose disease. However, these data and methods of analysis are very rarely used to find pre-disease conditions or treat undiagnosed malaise. Masatoshi Kaneko Ph.D. found that many pre-disease conditions and types of malaise could be detected using his unique method of blood data analysis, and could also be treated using personalized nutritional therapy as an alternative to using drugs. The authors of this article introduce personalized nutritional therapy based on blood data analysis (Kaneko’s method), and present and discuss some clinical cases. In total, 253 pre-disease or undiagnosed patients were treated using this nutritional therapy approach, and most of them recovered from their chronic symptoms and pre-disease conditions. This novel nutritional therapy has the potential to help many presymptomatic and undiagnosed patients suffering from malaise.

PT257 Positive Serology tendency for chagas disease in public hospital of Buenos Aires suburbs, in an 18 year period

Malaria is a parasitic infection of global importance. Although relatively uncommon in developed countries, in endemic regions, malaria is significant cause of morbidity and mortality and creates enormous social and economic burdens. Plasmodium vivax and Plasmodium falciparum are the most common malaria parasite species in Pakistan. Present study concerned with prevalence of malarial parasites and their effect on patient blood Chemistry.For the prevalence study we have examined 3500 patients suspected to be suffering from malaria. The blood films of these patients were examined by graham staining.Slide positivity rate was 22 percent i.e. 767 were positive. Of the positive slides 767 shows 55 (7.2%). P. falciparum, while 712 (92.8%) show P. vivax. Among 767 patients 70 patients were selected to cheek the biochemical effect of these parasites on patient blood chemistry, such as to check Bilirubin, glucose, ALT and AST and creatinine. In present study bilirubin level increased significantly (P < 0.000013) in case of P. vivax and (P < 0.000008) in case P. falciparum. Hypoglycemia has been reported to occur in sever malaria but no significant change in glucose concentration was observed in present study i.e. P > 0.8060 in case of P. vivax and P > 0.8112 in case of P. falciparum. Similarly the AST and ALT level is reported to increase significantly in sever malaria but no such increase in present study i.e. AST and ALT value in case of P. vivax P > 0.29 and P > 0.47 respectively and in case of P. falciparum AST and ALT is non-significant i.e. P > 0.07425 and P > 0.837.The creatinine level is significantly increased in both cases the values being P > 0.000312 in case of P. vivax and P > 0.000349 in case P. falciparum.

Prevalence of human malaria parasite and its effects on patient blood chemistry in Pakistani population

Background and aimMalaria is a parasitic infection of global importance. Although relatively uncommon in developed countries, in endemic regions, malaria is significant cause of morbidity and mortality and creates enormous social and economic burdens. Plasmodium vivax and Plasmodium falciparum are the most common malaria parasite species in Pakistan. Present study concerned with prevalence of malarial parasites and their effect on patient blood Chemistry. Methods and materialsFor the prevalence study we have examined 3500 patients suspected to be suffering from malaria. The blood films of these patients were examined by graham staining. ResultsSlide positivity rate was 22 percent i.e. 767 were positive. Of the positive slides 767 shows 55 (7.2%). P. falciparum, while 712 (92.8%) show P. vivax. Among 767 patients 70 patients were selected to cheek the biochemical effect of these parasites on patient blood chemistry, such as to check Bilirubin, glucose, ALT and AST and creatinine. In present study bilirubin level increased significantly (P < 0.000013) in case of P. vivax and (P < 0.000008) in case P. falciparum. Hypoglycemia has been reported to occur in sever malaria but no significant change in glucose concentration was observed in present study i.e. P > 0.8060 in case of P. vivax and P > 0.8112 in case of P. falciparum. Similarly the AST and ALT level is reported to increase significantly in sever malaria but no such increase in present study i.e. AST and ALT value in case of P. vivax P > 0.29 and P > 0.47 respectively and in case of P. falciparum AST and ALT is non-significant i.e. P > 0.07425 and P > 0.837. ConclusionThe creatinine level is significantly increased in both cases the values being P > 0.000312 in case of P. vivax and P > 0.000349 in case P. falciparum.

İSOTRETİNOİN TEDAVİSİNİN NÖTROFİL/LENFOSİT ORANI VE DİĞER HEMOGRAM PARAMETRELERİNE ETKİSİNİN DEĞERLENDİRİLMESİ

Aim: There are reports of various side effects of isotretinoin. Recent studies have controversial results about the necessity of laboratory investigation including hemogram and blood chemistry of patients during the follow up periodon isotretinoin.We aimed to investigate the effects of isotretinoin on Neutrophil/lymhocyte ratio (NLR) a systemic inflammation marker and the other hemogram parameters. Material and methods: Sixty seven patients with moderate to severe acne vulgaris aged between 18 to 25, who were prescribed 0.5mg/kg isotretinoin, were included to the study. Patients’ hemogram parameters before treatment and at the third month of treatment were recorded on SPSS 20.0 programme retrospectively. The difference between two values <0.05 was considered as statistically significant. Results: There were 37 female and 30 male patients, with a mean age of 21.12±3.54 years. There were no differences between the two groups by means of white blood count, neutrophil, lymphocyte counts and NLR. Among the other parameters, there was a statistically significant increase in monocyte count whereas basophil, eosinophil, platelet counts and hematocrit values revealed no differences. Red blood cells, hemoglobin, mean corpuscular volume and plateletocrit values revealed a statistically significant decrease (p<0.01). Conclusion: Isotretinoin, which is used as a miracle drug and favorable treatment of acne, may cause changes in hemogram parameters. It may lead to decreased hemoglobin values and increase of monocyte count during treatment. Patients with prominent iron deficiency may require close monitorization. Besides the unchanged NLR values may support no inflammatory reactions occur during muticentered studies, evaluating these parameters with larger sample sizes are required. isotretinoin treatment. Obviously

Intraventricular chordoid meningioma presenting with Castleman disease due to overproduction of interleukin-6

A rare case of chordoid meningioma in the lateral ventricle observed in an adult is reported. The first clinical manifestation of the disease was a prolonged fever of unknown origin. Abnormalities in the patient's blood chemistry, principally polyclonal hypergammaglobulinemia (immunoglobulin [Ig]G, IgA, and markedly IgE) and an elevated serum level of C-reactive protein, were associated with the disease. The tumor was histologically confirmed to be a chordoid meningioma, and its surgical removal resulted in complete resolution of the patient's symptoms. By combining reverse transcription-polymerase chain reaction and immunohistochemical analysis, it may be shown that cytokine production, including that of interleukin (IL)-6, IL-1beta, and vascular endothelial growth factor, plays a role in the pathogenesis of chordoid meningioma associated with Castleman syndrome.

Multifocal intraportal invasion of breast carcinoma diagnosed by laparoscopy-assisted liver biopsy

Hepar lobatum carcinomatosum (HLC) is defined as an acquired hepatic deformity consisting of an irregularly lobulated hepatic contour caused by intravascular infiltration of metastatic carcinoma. To date, only nine cases of HLC have been reported in the literature. We report a case of a 68-year-old woman showing hepatic metastasis of breast carcinoma in radiologically unidentified form. Initially, she received left partial mastectomy for breast cancer but solid hepatic metastases were identified in S(2) and S(6), 9 mo after surgery. Then, they responded to chemotherapy and radiologically disappeared. After radiological disappearance of the liver tumors, the patient's blood chemistry showed abnormal liver function. A CT scan demonstrated heterogeneous enhancement effect in the liver in the late phase, suggesting uneven hepatic blood supply. Hepatic deformity was not obvious. Laparoscopy revealed a slightly deformed liver surface with multiple indentations and shallow linear depressions. Furthermore, a wide scar was observed on the surface of S(2) possibly at the site where the metastatic tumor existed before chemotherapy. Liver biopsy from the wide scar lesion showed intraportal tumor thrombi with desmoplastic change. Because of its similarity to the histology of the original breast cancer, we concluded that the hepatic functional abnormalities and slightly deformed liver surface were derived from the circulatory disturbance caused by microscopic tumor thrombi. Besides, since the wide scar was located at the site of the pre-existing tumor, it is probable that chemotherapy was an important cause of fibrous scarring as a result of tumor regression. These morphologic findings are compatible with those of HLC. Laparoscopy-assisted liver biopsy was useful to make definite diagnosis, even though the hepatic deformity was radiologically undetectable.

Changes in the blood chemistry of patients with disseminated carcinoma of the breast during endocrine therapy.

Changes in the blood chemistry of patients with disseminated carcinoma of the breast during endocrine therapy.

Cystadenoma of the pancreas: Removal through vertical incision in the gastrohepatic omentum

It is noteworthy that the history of this patient contained very little that was suggestive of her real disorder. Initially even pelvic origin of the tumor was considered, because it projected itself largely in the umbilical area as the diagrams which were made at this time indicate. A neoplasm of the transverse colon or an omental mass might also be found in this location. Not until the patient was under anesthesia was its attachment in the upper abdomen clearly defined making a cyst of the pancreas likely. The gastrohepatic omentum was found stretched over the presenting tumor and was incised vertically instead of according to the usual technique. This opening, with slight lateral traction, afforded sufficient working room. Vertical incision had the advantage of being in itself bloodless and obviated the necessity of severing the vascular attachment of the gastrohepatic omentum to the lesser curvature of the stomach. As was expected the removal of a small strip of pancreas at the vascular base of the tumor had no noticeable effect on the patient's blood chemistry. Another deviation from the usual procedure was the avoidance of all drainage of the tumor bed. The reflex upset caused during convalescence by drains lodged in this region, as well as the formation of adhesions and delay in the complete closure of the abdominal wound may be factors of some importance; and, where there is reason to believe that the hemostasis is secure, the bed is dry and the wound is clean such drainage appears unnecessary. A review of the literature reveals that a number of conditions which are not true neoplasms have been classified as pancreatic cysts, and, in other instances the pathology was too meager to establish that the tumor was a true cystadenoma. The growth which is described here is histologically a benign neoplasm and belongs to the group of true cystadenomata. The number of cystadenomata of the pancreas recorded as successfully removed is comparatively limited. In this patient it was an advantage that the cystic tumor had its vascular attachment to the tapering body of the pancreas. If it had arisen nearer the head of the gland, the simpler technique might not have been applicable.