İSOTRETİNOİN TEDAVİSİNİN NÖTROFİL/LENFOSİT ORANI VE DİĞER HEMOGRAM PARAMETRELERİNE ETKİSİNİN DEĞERLENDİRİLMESİ

Abstract

Aim: There are reports of various side effects of isotretinoin. Recent studies have controversial results about the necessity of laboratory investigation including hemogram and blood chemistry of patients during the follow up periodon isotretinoin.We aimed to investigate the effects of isotretinoin on Neutrophil/lymhocyte ratio (NLR) a systemic inflammation marker and the other hemogram parameters. Material and methods: Sixty seven patients with moderate to severe acne vulgaris aged between 18 to 25, who were prescribed 0.5mg/kg isotretinoin, were included to the study. Patients’ hemogram parameters before treatment and at the third month of treatment were recorded on SPSS 20.0 programme retrospectively. The difference between two values <0.05 was considered as statistically significant. Results: There were 37 female and 30 male patients, with a mean age of 21.12±3.54 years. There were no differences between the two groups by means of white blood count, neutrophil, lymphocyte counts and NLR. Among the other parameters, there was a statistically significant increase in monocyte count whereas basophil, eosinophil, platelet counts and hematocrit values revealed no differences. Red blood cells, hemoglobin, mean corpuscular volume and plateletocrit values revealed a statistically significant decrease (p<0.01). Conclusion: Isotretinoin, which is used as a miracle drug and favorable treatment of acne, may cause changes in hemogram parameters. It may lead to decreased hemoglobin values and increase of monocyte count during treatment. Patients with prominent iron deficiency may require close monitorization. Besides the unchanged NLR values may support no inflammatory reactions occur during muticentered studies, evaluating these parameters with larger sample sizes are required. isotretinoin treatment. Obviously