The importance of hand hygiene (HH) in the healthcare setting is universally accepted. It is of particular importance in the realm of oncology in which a large percentage of patients are immunocompromised. While most patients have a good understanding of HH practices, for a variety of reasons patients rarely question their healthcare providers (HCP) about HH. In this feasibility study, in order to promote patient empowerment with regards to HH we used an innovative strategy called a Patient Motivational Dialogue (PMD), a scripted dialogue where physicians encourage patients to ask HCPs to wash their hands at every clinic visit. It was hypothesized that patients would feel more comfortable and advocate more often for proper HH once encouraged and instructed to do so by a physician. Eligible study participants included all patients currently undergoing radiation therapy at our institution. The PMD was administered on initial clinic visit and PMDPlus, a shortened version of the PMD, was used for all follow up visits to reinforce HH self-advocacy. Through a semi-structured interview and a 10-question yes/no survey, consented patients’ pre and post-intervention impressions of HH were assessed. Answers to these surveys in addition to comments regarding participation in the program were recorded. At the time of writing, 22 of a projected 30 participants have enrolled in the study. 11 patients have completed the study, 10 patients are actively participating, and 1 patient has withdrawn from study. On pre-study survey, almost all patients expressed an understanding of appropriate HH practice and 96.2% (127/132) of questions directed at understanding HH were answered correctly. Similarly, almost all patients felt it was important that their HCP practiced good HH habits with 97.7% (43/44) of questions directed at appropriate hygeine practice confirming this. Despite all patients having a very good understanding and desire for proper HH practices and 77% (17/22) of patients responding that they felt comfortable asking a HCP to wash their hands, only 27.3% (6/22) of patients had ever explicitly asked their HCP to do so. Of the patients who had completed the study, 100% (11/11) of patients had asked their HCP to wash their hands and similarly 91% (10/11) of patients stated they felt comfortable asking in the future. Nearly all patients recognize the importance of HH, but patients rarely confront their HCP about it. The initial analysis of this feasibility study shows that by establishing a relationship in which it is the HCP that stresses the importance of HH, the PMD is effective at empowering patients to advocate for their own care and, more importantly, it gives them the tools to do so. While this study focuses specifically on HH, we strongly believe that these tools give patients the ability to advocate for other aspects of their care as well.