The delivery of information to patients with cancer is a primary responsibility of health professionals and it may improve patients' satisfaction with their involvement in treatment decisions. Clinical trials often involve more written and verbal information for patients. All patients who were receiving chemotherapy in Leicestershire during a 2-week period were asked to complete a questionnaire. The responses of clinical trial and non-trial patients were compared. Clinical trial patients were significantly more likely to have been informed about alternative treatment options and to feel that they had taken part in the decision to undergo chemotherapy. They were also significantly more likely to have received written and verbal information about diagnosis and treatment from a hospital nurse, and were more willing to approach a nurse with future questions. If greater patient participation in treatment decisions is advocated, more written and verbal information and closer involvement of hospital nurses should be considered for all forms of chemotherapy.