Objective: Bacterial and fungal infections, antimicrobial resistance (AMR) results of bacterial agents, and the effect of the pandemic
 on AMR were evaluated in hospitalized COVID-19 patients. In addition, the detected AMR rates were compared with the AMR rates
 of the pre-pandemic period.
 Patients and Methods: The isolates grown in respiratory and blood samples of adult patients hospitalized with the diagnosis of
 COVID-19 between March 2020 and December 2020 were evaluated retrospectively. The same data in hospitalized patients before the
 pandemic, between March and December 2019, were evaluated retrospectively.
 Results: A total of 724 samples were included in the study. The superinfection rate was found to be 15.3%. The most frequently isolated
 microorganisms are; Acinetobacter baumannii (34.4%), Staphylococcus aureus (10.8%), Klebsiella pneumoniae (9.7%) and Pseudomonas
 aeruginosa (7.3%). The lowest resistance rates in Klebsiella pneumoniae isolates were found for aminoglycosides, in Acinetobacter
 baumannii isolates were found for trimethoprim-sulfamethoxazole, in Pseudomonas aeruginosa isolates were found for amikacin.
 When pre-pandemic and pandemic AMR rates were compared; a significant increase in amikacin resistance was detected only in
 Klebsiella pneumoniae isolates during the pandemic period (P:0.049).
 Conclusion: The data we have presented may help clinicians in the selection of antimicrobials for empirical therapy by revealing the
 effect of the pandemic on AMR.