PurposeThe Irish Diabetic RetinaScreen Service offers Nationwide screening to all diabetics over the age of 12. It is internationally unique given the integrated nature of its screening and treatment arms. It is now well established, demonstrating impressive uptake with considerable clinical impact. The aim of this study is to explore the significant and increasing number of referrals from the Diabetic RetinaScreen Service with non‐diabetic eye disease. We determine the individual contributions of pathology sub‐groups and their respective outcomes.MethodsWe retrospectively examined a 12‐month referral assessment database from the Mater Misericordiae University Hospital treatment center from January 2016 to 2017. Non‐diabetic eye disease referrals were identified and analysed with respect to their frequency of referral and outcome.ResultsOne thousand nine hundred and ninety‐three patients seen in the MMUH during the 12‐month period were included in the study. Diabetic eye disease referrals comprised 1250/1993 (63%) referrals, with 743/1993 (37%) referred for assessment of non‐diabetic eye disease. Substantial pathology sub‐groups included retinal artery and vein occlusions; Arterial emboli; Cataract; Glaucoma; Age Related Macular Degeneration; and Pigmented retinal lesions. We discuss the relative contribution from each pathology and the subsequent assessment outcomes.ConclusionsSeveral non‐diabetic, sight threatening ocular pathologies, which are often asymptomatic in their early course, are being identified and referred for appropriate treatment. The referral volume is increasing. Quantifying this promotes a more informed discussion on increased service demands, helping predict its practical and financial impact, and influencing strategies on future service provisions.