For the first time a pathogenesis of restless legs syndrome has been viewed from the positions of a systematic pathology of the nervous system disaccordance of motion formation programme in the central nervous system and in peripheric agents activity under the conditions of a latent myofascial trigger point of musculus gastrocnemius. An actual peripheric factor myofascial trigger point is an initiating and a maintaining chain in the genesis of restless legs syndrome. Development of a typical picture of restless legs syndrome occurs in the conditions of a minimal dysfunction in mesodiencephalic part of cerebrum formation of generators of pathologically increased excitement at different levels of a motion formation system.