The risk factors of Metabolic syndrome (Mets), primarily favors the development of cardiometabolic alteration, type 2 diabetes, hypertension, and dyslipidemia leading to increase in morbidity. Life style and eating habits often increases the levels of Uric acid (UA) in circulation. Elevated UA & stress, exacerbates the pain and inflammation. The inflammatory response includes systemic increase in circulating inflammatory cytokines and acute phase protein, high sensitive C-reactive protein (hs-CRP). Adiponectin (ADI) a cytokines primarily secreted by adipocytes exerts antidiabetic, anti-inflammatory & cardioprotective effects. Thus the purpose of the study is to establish a link between Adiponectin, Uric acid and hs-CRP which may further be used in diagnosis and thus can positively reverse many of the adverse effects of MetS. Present study, an observational case-control study conducted on referred MetS patients attending OPD at Chhatrapati Shivaji Subharti Hospital, Meerut. Data collected on previously validated questionnaire from 235 subjects (156 with MetS and 79 non-MetS) assessed for anthropometric measurements, diabetic profile, ADI, UA & hs-CRP were evaluated by standard established techniques. The results obtained from Mets patients were compared with non-MetS subjects, where ADI was significantly lower (P<0.05) while hs- CRP& UA were significantly higher in subjects with MetS (P<0.01). In Spearman’s rank correlation coefficient for the relationship between ADI and metabolic variables - ADI was positively correlated with age, diastolic blood pressure, total cholesterol, HDL-C& LDL-C while negatively correlated with BMI, systolic blood pressure, fasting glucose, Triglyceride& VLDL-C. Serum hs-CRP levels were elevated with the increasing number of MetS components, being higher among those with ≥ 2 components of MetS while adiponectin decreasing with the number of MetS components. Decreased levels were reported for ADI, whereas hs-CRP & UA levels were escalating.Higher levels of hs-CRP & Uric Acid with lower level of ADI associated with significantly higher risk of MetS.