Pathohistological Study Research Articles

Pathohistological Study on the Benign Changes of Papilla of Vater Including the Relationship between Biliary Tract and Pancreas

Pathohistological Study on the Benign Changes of Papilla of Vater Including the Relationship between Biliary Tract and Pancreas

The clinical and pathohistological study on the partial cystectomy for bladder cancer. IV. Observation of the effect of ureteroneocystostomy on the upper urinary tract activity (author's transl)

With the cases of partial cystectomy for bladder cancer, the clinical effect of ureteroneocystostomy on the upper urinary tract activity was studied by examining the IVP findings as well as the location of the neostomy, and the following results were obtained.1) No VUR was found in 98% of the cases in both sides, including neostomised side, one year after the surgery.2) No hydronephrotic sign on the IVP film could be found in 92% of the cases one year after operation.3) IVP findings one year after the operation were investigated according to the location of the ureteroneocystostomy. Exellent results were obtained in the cases with the neostomy on the dorsal wall or the dome of the bladder, and the cases with lateral wall neostomy was subsequently followed.Most satisfactory results were obtained in the cases with the neostomy on the opposite side of partial cystectomy, even in the time of discharge. With the results obtained above, it is assumed that the ureteroneocystostomy combined with the partial cystectomy for bladder cancer should be performed on the lateral wall or the dome of the bladder. Furthermore, the neostomy on the opposite side seems to be effective in preventing the unexpected effect on the upper urinary tract immediately after the surgery.

A family with familial colonic polyposis and cancerization

I wish to present 1 family 2 sisters with familial colonic polyposis.Case 1 is a 25-year-old woman, complaining of diarrhea with massive blood coagula. She was found to have diffuse colonic polyposis with rectal cancer and was performed total colectomy. Her father had died of rectal cancer. Her eldest sister, that is, case 2 was also found by laparatomy to have diffuse colonic polyposis with sigmoid cancer. Her youngest sister was found by sigmoidscopy to have rectal polyposis (3 polyps were found in the rectum). So, I can say to have a family of familial colonic polyposis.In order to determine whether there was a presence of precancerous lesions, a patho-histological study of all polyps was carried out on the numerous polyps of the colon and rectum of case 1. These results were as follows:1) The total number of polyps was 920 and they were pathohistologically all sessil adenomatous polyps except for one which was pedunculated.2) These polyps were classified into five groups according to their degree of malignancy from atypia 0, atypia 1, atypia 2, atypia 3 and cancer. The result was atypia 0-260 (28.2 %), atypia 1-234 (25.4 %), atypia 2-256 (27.8 %), atypia 3-137 (14.9 %) and cancer-33 polyps (3.6 %).3) The highest incidence of site for malignant polyps was found in the order of descending colon, sigmoid colon, rectum, rectosigmoid, and transverse colon.4) Most of the malignant polyps were large in size, but 75 polyps (8.1 %) were less than 2 mm. in diameter.5) The polyps were equally distributed among the colon.Cass 2 is a sister of case 1. She was also founb to have colonic polyposis with sigmoid cancer. Only sigmoidectomy was carried out and 42 polyps surrounding a sigmoid cancer were removed. None of 42 polyps were cancerous, but 18 of them were of the atypia 2 type.The electron microscopic findings of a few of case 2 patient's polyps showed slight atypia such as gathering of chromatin, irregularly shaped nucleolus, and very few microvilli. There were relatively few Goblet Cells in the polyps. The findings of another one showed a more severe degree of malignacy such as almost no microvilli and slightly increased in number of endoplasma reticulum.

89. Sensory Hyperirritability from Intratheeal Alumina Gel Injection in Cats. A Pathohistological Study

89. Sensory Hyperirritability from Intratheeal Alumina Gel Injection in Cats. A Pathohistological Study

A Study On The Chemotherapy In Clonorchiasis. Report: 3. The Patho-Histological Study On The Liver Of Rabbit Healed From Clonorchiasis By Chemotherapy

In the experimental rabbits which were previously infected with Clonorchis sinensis and were thereafter administered with Dithiazanine iodide, the patho-histological and some histochemical changes were observed in the healed liver(76 days after stoppage of egg excretion). And also, the patho-histological changes which appeared in the infected and healed livers respectively were compared from each other. The following results and conclusion were obtained. 1)In the infected group, grossly the liver showed a considerable increase of its weight, an increased vascular marking of its surfaces and an increase in consistency and thickness of the bile ducts. However, the healed group grossly showed no remarkable changes in the liver. 2)In the infected group, microscopically the liver showed a marked adenomatous hyperplasia of bile ducts, proliferation of bile ductules and marked periductal and periductular fibrosis with infiltration of chronic inflammatory cells in portal spaces. A histochemical study showed that the increased fibrous tissue consists largely with collagenous fibers and partly with reticulum fibers. 3)In the group with healed liver microscopically the liver showed much improvement in the histopathological changes compared to those of the infected group. In the healed lover there remained only slight histopathological changes mainly in portal spaces of the liver, such as considerably diminished periductal and periductular fibrosis. The slightly increased fibrous tissue consists largely with reticulum fibers and partly with collagen fibers.

TYMPANOPLASTY AND FOSSULA FENESTRAE VESTIBULI

During tympanoplasty the authors encountered seven cases with abnormal motility of the stapes which spontaneously became dislocated in the cleaning procedure of the pathologic granulation tissue about the stapes. No efflux of perilymph was noted and fenestra ovalis membrane was intact in these cases in which vertigo and vomiting were not experienced. In making a pathohistological study of the stapes of these cases a very specific pathologic observation was made on the correlation between the stapes and fenestra ovalis membrane, that is between the wall of the perilymphatic cavity and margin of the fenestra ovalis. A consideration was therefore attempted on the causes of the decrease of hearing acuity following tympanoplasty.

Pathohistological Study of the Palatine Tonsil as the Focus of Focal Infection

Pathohistological Study of the Palatine Tonsil as the Focus of Focal Infection

A clinical and pathohistological study of the plica triangularis

A clinical and pathohistological study of the plica triangularis

PATHO-HISTOLOGICAL STUDY OF THE GASTROINTESTINAL TRACT DURING ARTIFICIAL PNEUMOPERITONEUM

In the past, 3 reports on the clinical and experimental studies regarding the effect of artificial pneumoperitoneum on intestinal absorption were made and for this report, a patho-histological study of the gastrointestinal tract was undertaken. The purpose of this study was not only to explain the conditions governing absorption by the gastroin-testinal tract during artificial pneumoperitoneum, but because this author felt that it was a problem clinically requiring elucidation. For the experiment, 24 healthy, white, adult rabbits were selected and using 4 types of gas, viz., oxygen, carbon dioxide, air and nitrogen, normotensive and hypertensive pneumoperitoneum groups were established. After continuation of this method for 6 months (the hypertensive group with air was observed after 2.5 _??_ 5 months, the hyper-tensive group with nitrogen was observed after 2 months), the rabbits were autopsied and histological specimens were made of 9 parts, namely, the stomach, duodenum, jejunum, ileum, cecum, ascending colon, transverse colon, descending colon and rectum. The results for each of the series showed that similar findings were hypertrophy of the serous membrane, edema of the mucous membrane and circulatory disturbance and in the oxygen series hyperemia and congestion were observed to be mild in the normotensive group, but extremely severe in the hypertensive group. In the carbon dioxide series this tendency proved to be milder in comparison to the oxygen series. In the series using air, hyperemia, especially congestion was confirmed along the entire gastrointestinal tract and the degree of this finding was noted to be greater in the hypertensive group as compared to the normotensive group. Furthermore this phenomenon was noted to be more marked than that of the oxygen series. In the nitrogen series, almost no hyperemia or congestion was noted as in the above 3 series, but in addition, anemia and atrophy and degeneration of the mucous membrane was confirmed. This tendency proved to be greater in the hypertensive group rather than the normotensive group. As for hypertrophy of the glands, the degree was noted to be greater in the order of oxygen, carbon dioxide and air and in each series, it was higher with the normotensive group as compared to the hypertensive group. However, almost no glandular hypertrophy was noted in the nitrogen series.

A Pathohistological Study on Cancer of Uterine Cervix Irradiated with Isotope Co60

A Pathohistological Study on Cancer of Uterine Cervix Irradiated with Isotope Co⁶⁰

Pathohistological study on tuberculin reaction produced in human nasal mucosa

Pathohistological study on tuberculin reaction produced in human nasal mucosa

口蓋内被腫の病理組織学的検索

口蓋内被腫の病理組織学的検索