Purpose In the field of digital entrepreneurship, achieving high growth in digital start-ups is crucial. This paper aims to explore how causal conditions at the individual, organizational and environmental levels interact in the growth process of digital start-ups. Furthermore, it uses a configurational approach to conduct a holistic analysis of the cross-level interaction mechanisms that enable digital start-ups to achieve high growth. Design/methodology/approach Based on a holistic perspective, the data collection included 57 representative cases of digital start-ups in China in the past decade (2014–2023). A fuzzy set qualitative comparative analysis was conducted to explore the cross-level interaction mechanism of the three-dimensional causal conditions of the environment, organization and individual entrepreneurs on high growth among digital start-ups. Findings This study found three models for digital start-ups to achieve high growth. These models − the resource network orchestration model, the innovation resource development model and the entrepreneurial spirit coherence model, respectively, reflect the multiple paths of high growth achieved by various digital start-ups based on their entrepreneurial environment, organizational capability and the personality of the founder. This reflects that digital start-ups face different conditions and entrepreneurial situations, with differing cross-level interaction mechanisms for achieving high growth. Practical implications First, digital start-ups should focus on strengthening their digital resource integration capabilities to lay the foundation for their subsequent high-growth path selection. Second, entrepreneurs need to adopt a holistic perspective to change or strengthen the causal conditions required to achieve high growth. Third, emphasis should be placed on the coherence between the entrepreneur’s need for achievement and the internal entrepreneurial culture. Originality/value First, this study contributes to the literature on high growth among digital start-ups by introducing a cross-level interaction mechanism comprising environmental, organizational and entrepreneurial causal conditions. Second, it reveals that individual factors at the environmental, organizational and entrepreneurial levels are not necessary conditions for high entrepreneurial growth and that digital resource integration capabilities play a more universal role in achieving high digital start-up growth. Finally, the study provides a cross-level holistic explanation of how digital start-ups can achieve high growth and reveals various configuration models conducive to high growth, thus offering practical insights for businesses.
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