Rationale: Transcatheter interventional closure therapy is the main treatment method for patent foramen ovale (PFO). However, occluder abscission is a serious complication in PFO interventional therapy. Thus, timely and effective management of the occluder detachment is crucial for improving patient prognosis. Patient concerns: A 52-year-old female patient was admitted to the Department of Neurology mainly due to “right upper limb weakness for two days, which aggravated for eight hours.” The patient had no history of any other diseases. Diagnoses: The patient was diagnosed with an atrial septal defect (foramen ovale type) and cerebral infarction. Interventions and outcomes: The occluder abscission was successfully removed after several attempts with the help of the snare device. Lessons: When the PFO occlusion device is detached, interventional treatment would lead to minimal trauma, fast postoperative recovery, and a definite therapeutic effect. Based on mastering the indications and standardizing the operational process, this is a safe and effective minimally invasive treatment method.