The study examines the spatiotemporal dynamics of landscape anthropization in the Kiziba-Baluba Hunting Domain (KBHD), near Lubumbashi in southeastern Democratic Republic of Congo, facing increasing human threats. It assesses these dynamics from 1989 to 2023 using remote sensing, Geographic Information Systems (GIS), and landscape ecology principles. The results reveal a significant decrease in forest cover, declining from 70.33 % in 1989 to 26.22 % in 2023, with an annual deforestation rate of -1.84 %. This deforestation has led to the expansion of savannas (63.93 %), agriculture (5.76 %), and built-up and bare soil (0.93 %) through patch creation and aggregation. The level of landscape disturbance has increased sixfold over 34 years, from 0.42 in 1989 to 2.81 in 2023. The reduction in the size of the largest forest patch and increased spatial isolation show rising fragmentation and dissection, often followed by the attrition of residual patches. These findings highlight the inefficiency of current conservation measures in KBHD, indicating a need for restructuring management, redefining protected area boundaries, developing a suitable management plan, implementing reforestation programs, strengthening enforcement of environmental laws, and actively involving local communities.