Patch Stage Of Mycosis Fungoides Research Articles

Foxp3+ T-lymphocytes in the pathogenesis of mycosis fungoides

The pathogenesis of mycosis fungoides (MF) is not fully understood, nevertheless it is believed that the microenvironment of the tumor cells could influence the development of malignant lymphocytes. T-regulatory cells are a specialized subpopulation of T-lymphocytes, which can have an immunosuppressive effect and thus affect the immune response. Goal. The study population of regulatory T-cells in the skin of patients with mycosis fungoides and llaque parapsoriasis. Materials and methods. The content of Foxp3+ and CD3+ cells by immunohistochemical studies of skin biopsy specimens from patients with patch stage mycosis fungoides (10 patients) and plaque parapsoriasis (10 patients). The control group consisted of 16 healthy individuals. Results. Relative expression area Foxp3+ cells in patients with mycosis fungoides patch stage (0.44%) 2.6 times greater than in patients with plaque parapsoriasis (0,14%; p < 0,05). Part the Foxp3+ cells of the total number of T lymphocytes in patients with patch stage mycosis fungoides (5.9%) and plaque parapsoriasis (4.7%) were not significantly different (p > 0,05). Conclusion. In the initial stage of patients with mycosis fungoides determined a statistically significant predominance of the absolute number of T-regulatory cells in the epidermis and in the dermis. Part T-regulatory cells from all of T-lymphocytes in patients with skin patch stage mycosis fungoides and plaque parapsoriasis not statistically significantly different.

Ichthyosiform large plaque parapsoriasis: Report of a rare entity

Large plaque parapsoriasis (LPP) is an idiopathic, chronic scaly dermatosis classified within parapsoriasis group of diseases, occurring commonly in middle aged patients of all races and geographic regions. LPP and its variants are closely related to the patch stage of mycosis fungoides. The two types of LPP mostly described are the poikilodermatous and retiform parapsoriasis. We are reporting an ichthyosiform LPP for its rarity.

The conundrum of parapsoriasis versus patch stage of mycosis fungoides

Terminological confusion with benign dermatosis, such as parapsoriasis en plaques, makes it difficult to diagnose mycosis fungoides in the early patch stage. Early diagnosis of mycosis fungoides (MF) is important for deciding on type of therapy, prognosis and for further follow-up. However, until recently, there has been no consensus on criteria that would help in diagnosing the disease early. Some believe that large plaque parapsoriasis (LPP) should be classified with early patch stage of MF and should be treated aggressively. However, there is no firm clinical or laboratory criteria to predict which LPP will progress to MF and we can only discuss about statistical probability. Moreover, long-term outcome analysis of even patch stage of MF is similar to that of control population. We therefore believe that LPP should be considered as a separate entity at least to prevent the patient from being given a frightening diagnosis. We also feel that patients need not be treated with aggressive therapy for LPP and will need only a close follow-up. This article emphasizes the criteria for diagnosing early MF and has highlighted the importance of considering LPP as a distinct benign entity.

下腿の腫脹を伴った紅斑期菌状息肉症

A 45-year-old woman presented with scaly erythema on her trunk and extremities and a swelling of her left lower leg, both of which were noticed 6 years ago. A biopsy specimen from the skin showed intraepidermal infiltration of atypical lymphocytes, the finding consistent with patch-stage of mycosis fungoides (MF) . Infiltration of the same small atypical lymphocytes was also observed in the fascia and the muscle of her left lower leg associated with prominent granulomatous reaction containing many multinuclear giant cells.Immunohistochemistry showed that surface phenotypes of atypical lymphocytes infiltrating skin as well as muscle were CD3+, CD4+, CD5+, CD45RO+, CD8-, CD56-, TIAI-, and granzymeB-. Southern blot and PCR analysesshowed evidence of a clonal T-cell receptor rearrangement in skin specimens, but the results were ambiguous in muscle samples. No other visceral lesion was not detected. There was no evidence of either sarcoidosis or tuberculosis. Psoralen plus ultraviolet A therapy was effective for the skin lesion, but 30Gy of X-ray irradiation to the left lower leg made no response. The possible implications of the coexistence of the two separate lesions in the skin and the muscle were discussed. [Skin Cancer (Japan) 2003; 18: 255-258]

Do you make the diagnosis histologically of large plaque parapsoriasis? If you do, please give the histological and clinical differentiation from the patch stage of mycosis fungoides

Do you make the diagnosis histologically of large plaque parapsoriasis? If you do, please give the histological and clinical differentiation from the patch stage of mycosis fungoides