Patch-based Method Research Articles

A lightweight CNN-Transformer network for pixel-based crop mapping using time-series Sentinel-2 imagery

Deep learning approaches have provided state-of-the-art performance in crop mapping. Recently, several studies have combined the strengths of two dominant deep learning architectures, Convolutional Neural Networks (CNNs) and Transformers, to classify crops using remote sensing images. Despite their success, many of these models utilize patch-based methods that require extensive data labeling, as each sample contains multiple pixels with corresponding labels. This leads to higher costs in data preparation and processing. Moreover, previous methods rarely considered the impact of missing values caused by clouds and no-observations in remote sensing data. Therefore, this study proposes a lightweight multi-stage CNN-Transformer network (MCTNet) for pixel-based crop mapping using time-series Sentinel-2 imagery. MCTNet consists of several successive modules, each containing a CNN sub-module and a Transformer sub-module to extract important features from the images, respectively. An attention-based learnable positional encoding (ALPE) module is designed in the Transformer sub-module to capture the complex temporal relations in the time-series data with different missing rates. Arkansas and California in the U.S. are selected to evaluate the model. Experimental results show that the MCTNet has a lightweight advantage with the fewest parameters and memory usage while achieving the superior performance compared to eight advanced models. Specifically, MCTNet obtained an overall accuracy (OA) of 0.968, a kappa coefficient (Kappa) of 0.951, and a macro-averaged F1 score (F1) of 0.933 in Arkansas, and an OA of 0.852, a Kappa of 0.806, and an F1 score of 0.829 in California. The results highlight the importance of each component of the model, particularly the ALPE module, which enhanced the Kappa of MCTNet by 4.2% in Arkansas and improved the model’s robustness to missing values in remote sensing data. Additionally, visualization results demonstrated that the features extracted from CNN and Transformer sub-modules are complementary, explaining the effectiveness of the MCTNet.

Anatomy-constrained synthesis for spleen segmentation improvement in unpaired mouse micro-CT scans with 3D CycleGAN

Objective. Auto-segmentation in mouse micro-CT enhances the efficiency and consistency of preclinical experiments but often struggles with low-native-contrast and morphologically complex organs, such as the spleen, resulting in poor segmentation performance. While CT contrast agents can improve organ conspicuity, their use complicates experimental protocols and reduces feasibility. We developed a 3D Cycle Generative Adversarial Network (CycleGAN) incorporating anatomy-constrained U-Net models to leverage contrast-enhanced CT (CECT) insights to improve unenhanced native CT (NACT) segmentation. Approach. We employed a standard CycleGAN with an anatomical loss function to synthesize virtual CECT images from unpaired NACT scans at two different resolutions. Prior to training, two U-Nets were trained to automatically segment six major organs in NACT and CECT datasets, respectively. These pretrained 3D U-Nets were integrated during the CycleGAN training, segmenting synthetic images, and comparing them against ground truth annotations. The compound loss within the CycleGAN maintained anatomical fidelity. Full image processing was achieved for low-resolution datasets, while high-resolution datasets employed a patch-based method due to GPU memory constraints. Automated segmentation was applied to original NACT and synthetic CECT scans to evaluate CycleGAN performance using the Dice Similarity Coefficient (DSC) and the 95th percentile Hausdorff Distance (HD95p). Main results. High-resolution scans showed improved auto-segmentation, with an average DSC increase from 0.728 to 0.773 and a reduced HD95p from 1.19 mm to 0.94 mm. Low-resolution scans benefited more from synthetic contrast, showing a DSC increase from 0.586 to 0.682 and an HD95p reduction from 3.46 mm to 1.24 mm. Significance. Implementing CycleGAN to synthesize CECT scans substantially improved the visibility of the mouse spleen, leading to more precise auto-segmentation. This approach shows the potential in preclinical imaging studies where contrast agent use is impractical.

Continual few-shot patch-based learning for anime-style colorization

The automatic colorization of anime line drawings is a challenging problem in production pipelines. Recent advances in deep neural networks have addressed this problem; however, collectingmany images of colorization targets in novel anime work before the colorization process starts leads to chicken-and-egg problems and has become an obstacle to using them in production pipelines. To overcome this obstacle, we propose a new patch-based learning method for few-shot anime-style colorization. The learning method adopts an efficient patch sampling technique with position embedding according to the characteristics of anime line drawings. We also present a continuous learning strategy that continuously updates our colorization model using new samples colorized by human artists. The advantage of our method is that it can learn our colorization model from scratch or pre-trained weights using only a few pre- and post-colorized line drawings that are created by artists in their usual colorization work. Therefore, our method can be easily incorporated within existing production pipelines. We quantitatively demonstrate that our colorizationmethod outperforms state-of-the-art methods.

An enhanced speech emotion recognition using vision transformer

In human–computer interaction systems, speech emotion recognition (SER) plays a crucial role because it enables computers to understand and react to users’ emotions. In the past, SER has significantly emphasised acoustic properties extracted from speech signals. The use of visual signals for enhancing SER performance, however, has been made possible by recent developments in deep learning and computer vision. This work utilizes a lightweight Vision Transformer (ViT) model to propose a novel method for improving speech emotion recognition. We leverage the ViT model’s capabilities to capture spatial dependencies and high-level features in images which are adequate indicators of emotional states from mel spectrogram input fed into the model. To determine the efficiency of our proposed approach, we conduct a comprehensive experiment on two benchmark speech emotion datasets, the Toronto English Speech Set (TESS) and the Berlin Emotional Database (EMODB). The results of our extensive experiment demonstrate a considerable improvement in speech emotion recognition accuracy attesting to its generalizability as it achieved 98%, 91%, and 93% (TESS-EMODB) accuracy respectively on the datasets. The outcomes of the comparative experiment show that the non-overlapping patch-based feature extraction method substantially improves the discipline of speech emotion recognition. Our research indicates the potential for integrating vision transformer models into SER systems, opening up fresh opportunities for real-world applications requiring accurate emotion recognition from speech compared with other state-of-the-art techniques.

3D Poissonian image deblurring via patch-based tensor logarithmic Schatten-p minimization

In medical and biological image processing, multi-dimensional images are often corrupted by blur and Poisson noise. In this paper, we first propose a new tensor logarithmic Schatten-p (t-log-Sp ) low-rank measure and a tensor iteratively reweighted Schatten-p minimization algorithm for minimizing such measure. Furthermore, we adopt this low-rank measure to regularize the non-local tensors formed by similar 3D image patches and develop a patch-based non-local low-rank model. The data fidelity term of the model characterizes the Poisson noise distribution and blur operator. The optimization model is further solved by an alternating minimization technique combined with variable splitting. Experimental results tested on 3D fluorescence microscope images show that the proposed patch-based tensor logarithmic Schatten-p minimization method outperforms state-of-the-art methods in terms of image evaluation metrics and visual quality.

Patch-Based Auxiliary Node Classification for Domain Adaptive Object Detection

Domain adaptive object detection (DAOD) aims to leverage labeled source domain data to train object detection models that can generalize well to unlabeled target domains. Recently, many researchers have considered implementing fine-grained pixel-level domain adaptation using graph representations. Existing methods construct semantically complete graphs and align them across domains via graph matching. This work introduced an auxiliary node classification task before domain alignment through graph matching, which utilizes the inherent information of graph nodes to classify them, in order to avoid suboptimal graph matching results caused by node class confusion. However, previous methods neglected the contextual information of graph nodes, leading to biased node classification and suboptimal graph matching. To solve this issue, we propose a novel patch-based auxiliary node classification method for DAOD. Unlike existing methods that use only the inherent information of nodes for node classification, our method exploits the local region information of nodes and employs multi-layer convolutional neural networks to learn the local region feature representation of nodes, enriching the node context information. Thus, accurate and robust node classification results are produced and the risk of class confusion is reduced. Moreover, we propose a progressive strategy to fuse the inherent features and the learned local region features of nodes, which ensures that the network can stably and reliably utilize local region features for accurate node classification. In this paper, we conduct abundant experiments on various DAOD scenarios and demonstrate that our proposed model outperforms existing works.

LogoStyleFool: Vitiating Video Recognition Systems via Logo Style Transfer

Video recognition systems are vulnerable to adversarial examples. Recent studies show that style transfer-based and patch-based unrestricted perturbations can effectively improve attack efficiency. These attacks, however, face two main challenges: 1) Adding large stylized perturbations to all pixels reduces the naturalness of the video and such perturbations can be easily detected. 2) Patch-based video attacks are not extensible to targeted attacks due to the limited search space of reinforcement learning that has been widely used in video attacks recently. In this paper, we focus on the video black-box setting and propose a novel attack framework named LogoStyleFool by adding a stylized logo to the clean video. We separate the attack into three stages: style reference selection, reinforcement-learning-based logo style transfer, and perturbation optimization. We solve the first challenge by scaling down the perturbation range to a regional logo, while the second challenge is addressed by complementing an optimization stage after reinforcement learning. Experimental results substantiate the overall superiority of LogoStyleFool over three state-of-the-art patch-based attacks in terms of attack performance and semantic preservation. Meanwhile, LogoStyleFool still maintains its performance against two existing patch-based defense methods. We believe that our research is beneficial in increasing the attention of the security community to such subregional style transfer attacks.

From Pixels to Prognosis: A Survey on AI-Driven Cancer Patient Survival Prediction Using Digital Histology Images.

Survival analysis is an integral part of medical statistics that is extensively utilized to establish prognostic indices for mortality or disease recurrence, assess treatment efficacy, and tailor effective treatment plans. The identification of prognostic biomarkers capable of predicting patient survival is a primary objective in the field of cancer research. With the recent integration of digital histology images into routine clinical practice, a plethora of Artificial Intelligence (AI)-based methods for digital pathology has emerged in scholarly literature, facilitating patient survival prediction. These methods have demonstrated remarkable proficiency in analyzing and interpreting whole slide images, yielding results comparable to those of expert pathologists. The complexity of AI-driven techniques is magnified by the distinctive characteristics of digital histology images, including their gigapixel size and diverse tissue appearances. Consequently, advanced patch-based methods are employed to effectively extract features that correlate with patient survival. These computational methods significantly enhance survival prediction accuracy and augment prognostic capabilities in cancer patients. The review discusses the methodologies employed in the literature, their performance metrics, ongoing challenges, and potential solutions for future advancements. This paper explains survival analysis and feature extraction methods for analyzing cancer patients. It also compiles essential acronyms related to cancer precision medicine. Furthermore, it is noteworthy that this is the inaugural review paper in the field. The target audience for this interdisciplinary review comprises AI practitioners, medical statisticians, and progressive oncologists who are enthusiastic about translating AI-driven solutions into clinical practice. We expect this comprehensive review article to guide future research directions in the field of cancer research.

Adversarial patch-based false positive creation attacks against aerial imagery object detectors

Although adversarial attacks have revealed weaknesses in Deep Neural Networks (DNNs)-based aerial detectors, they present a new paradigm for concealing vulnerable assets from autonomous detection systems onboard satellites. Among them, adversarial patches were widely applied due to their physical realizability. Nonetheless, most existing adversarial patch-based attack methods are developed to hide objects from detectors to achieve a vanishing attack. This paper proposes a novel Adversarial Patch False Positive Creation Attack (APFP-CA) framework that enables aerial detectors to recognize non-existent objects, thereby realizing a creation attack. Concretely, the APFP-CA models the creation attack as a two-stage optimization problem. The first stage uses a well-designed efficient loss function to increase the objectness score of patches placed anywhere in the scene to achieve untargeted attacks. The second stage involves elaborating two category-dependent loss functions for fulfilling targeted attacks. Experiments conducted on diverse datasets and detectors demonstrate the effectiveness and universality of our method. Transfer attacks across different datasets and models validate the generalizability of the optimized adversarial patches. Finally, we perform several proportionally scaled experiments physically to illustrate that the optimized adversarial patches can successfully deceive aerial detectors in the physical world. The proposed approach offers a novel contribution to adversarial attacks against aerial imagery objectors and holds potential for practical applications in high-security systems.

Deep image prior inpainting of ancient frescoes in the Mediterranean Alpine arc

The unprecedented success of image reconstruction approaches based on deep neural networks has revolutionised both the processing and the analysis paradigms in several applied disciplines. In the field of digital humanities, the task of digital reconstruction of ancient frescoes is particularly challenging due to the scarce amount of available training data caused by ageing, wear, tear and retouching over time. To overcome these difficulties, we consider the Deep Image Prior (DIP) inpainting approach which computes appropriate reconstructions by relying on the progressive updating of an untrained convolutional neural network so as to match the reliable piece of information in the image at hand while promoting regularisation elsewhere. In comparison with state-of-the-art approaches (based on variational/PDEs and patch-based methods), DIP-based inpainting reduces artefacts and better adapts to contextual/non-local information, thus providing a valuable and effective tool for art historians. As a case study, we apply such approach to reconstruct missing image contents in a dataset of highly damaged digital images of medieval paintings located into several chapels in the Mediterranean Alpine Arc and provide a detailed description on how visible and invisible (e.g., infrared) information can be integrated for identifying and reconstructing damaged image regions.

Group sparse representation and saturation-value total variation based color image denoising under multiplicative noise

<abstract><p>In this article, we propose a novel group-based sparse representation (GSR) model for restoring color images in the presence of multiplicative noise. This model consists of a convex data-fidelity term, and two regularizations including GSR and saturation-value-based total variation (SVTV). The data-fidelity term is suitable for handling heavy multiplicative noise. GSR enables the retention of textures and details while sufficiently removing noise in smooth regions without producing the staircase artifacts engendered by total variation-based models. Furthermore, we introduce a multi-color channel-based GSR that involves coupling between three color channels. This avoids the generation of color artifacts caused by decoupled color channel-based methods. SVTV further improves the visual quality of restored images by diminishing certain artifacts induced by patch-based methods. To solve the proposed nonconvex model and its subproblem, we exploit the alternating direction method of multipliers, which contributes to an efficient iterative algorithm. Numerical results demonstrate the outstanding performance of the proposed model compared to other existing models regarding visual aspect and image quality evaluation values.</p></abstract>

Fully Convolutional Network-Based Self-Supervised Learning for Semantic Segmentation.

Although deep learning has achieved great success in many computer vision tasks, its performance relies on the availability of large datasets with densely annotated samples. Such datasets are difficult and expensive to obtain. In this article, we focus on the problem of learning representation from unlabeled data for semantic segmentation. Inspired by two patch-based methods, we develop a novel self-supervised learning framework by formulating the jigsaw puzzle problem as a patch-wise classification problem and solving it with a fully convolutional network. By learning to solve a jigsaw puzzle comprising 25 patches and transferring the learned features to semantic segmentation task, we achieve a 5.8% point improvement on the Cityscapes dataset over the baseline model initialized from random values. It is noted that we use only about 1/6 training images of Cityscapes in our experiment, which is designed to imitate the real cases where fully annotated images are usually limited to a small number. We also show that our self-supervised learning method can be applied to different datasets and models. In particular, we achieved competitive performance with the state-of-the-art methods on the PASCAL VOC2012 dataset using significantly fewer time costs on pretraining.

A motion-corrected deep-learning reconstruction framework for accelerating whole-heart magnetic resonance imaging in patients with congenital heart disease

BackgroundMRI is an important imaging modality for the assessment and management of adult patients with congenital heart disease (CHD). However, conventional techniques for 3D whole-heart acquisition involve long and unpredictable scan times and methods that accelerate scans via k-space undersampling often rely on long iterative reconstructions. Deep-learning-based reconstruction methods have recently attracted much interest due to their capacity to provide fast reconstructions whilst often outperforming existing state-of-the-art methods. In this study, we sought to adapt and validate a non-rigid motion-corrected model-based deep-learning (MoCo-MoDL) reconstruction framework for 3D whole-heart MRI in a CHD patient cohort. MethodsThe previously proposed deep-learning reconstruction framework MoCo-MoDL, which incorporates a non-rigid motion-estimation network and a denoising regularisation network within an unrolled iterative reconstruction, was trained in an end-to-end manner using 39 CHD patient datasets. Once trained, the framework was evaluated in 8 CHD patient datasets acquired with seven-fold prospective undersampling. Reconstruction quality was compared with the state-of-the-art non-rigid motion-corrected patch-based low-rank reconstruction method (NR-PROST) and against reference images (acquired with three-or-four-fold undersampling and reconstructed with NR-PROST). ResultsSeven-fold undersampled scan times were 2.1 ± 0.3 minutes and reconstruction times were ~ 30 seconds, approximately 240 times faster than an NR-PROST reconstruction. Image quality comparable to the reference images was achieved using the proposed MoCo-MoDL framework, with no statistically significant differences found in any of the assessed quantitative or qualitative image quality measures. Additionally, expert image quality scores indicated the MoCo-MoDL reconstructions were consistently of a higher quality than the NR-PROST reconstructions of the same data, with the differences in 12 of the 22 scores measured for individual vascular structures found to be statistically significant. ConclusionThe MoCo-MoDL framework was applied to an adult CHD patient cohort, achieving good quality 3D whole-heart images from ~ 2-minute scans with reconstruction times of ~ 30 seconds.

A Patch-Based Method for Underwater Image Enhancement With Denoising Diffusion Models.

The enhancement of underwater images has emerged as a significant technological challenge in advancing marine research and exploration tasks. Due to the scattering of suspended particles and absorption of light in underwater environments, underwater images tend to present blurriness and predominantly color distortion. In this study, we propose a novel approach utilizing denoising diffusion models to improve underwater degraded images. After training the noise estimation network of the denoising diffusion models, we accelerate the deterministic sampling process with denoising diffusion implicit models. We also propose a patch-based method by implementing average sampling between overlapping image patches at each sampling step, enabling the generation of images at arbitrary resolution while preserving their natural appearance and details. Through benchmark experiments, we illustrate that our method outperforms or closely approaches state-of-the-art techniques in terms of effectiveness and performance. We demonstrate that our approach reduces the interference of underwater environments with the semantic information of the images by salient object detection experiments.

Combined Edge Loss UNet for Optimized Segmentation in Total Knee Arthroplasty Preoperative Planning.

Bone segmentation and 3D reconstruction are crucial for total knee arthroplasty (TKA) surgical planning with Personalized Surgical Instruments (PSIs). Traditional semi-automatic approaches are time-consuming and operator-dependent, although they provide reliable outcomes. Moreover, the recent expansion of artificial intelligence (AI) tools towards various medical domains is transforming modern healthcare. Accordingly, this study introduces an automated AI-based pipeline to replace the current operator-based tibia and femur 3D reconstruction procedure enhancing TKA preoperative planning. Leveraging an 822 CT image dataset, a novel patch-based method and an improved segmentation label generation algorithm were coupled to a Combined Edge Loss UNet (CEL-UNet), a novel CNN architecture featuring an additional decoding branch to boost the bone boundary segmentation. Root Mean Squared Errors and Hausdorff distances compared the predicted surfaces to the reference bones showing median and interquartile values of 0.26 (0.19-0.36) mm and 0.24 (0.18-0.32) mm, and of 1.06 (0.73-2.15) mm and 1.43 (0.82-2.86) mm for the tibia and femur, respectively, outperforming previous results of our group, state-of-the-art, and UNet models. A feasibility analysis for a PSI-based surgical plan revealed sub-millimetric distance errors and sub-angular alignment uncertainties in the PSI contact areas and the two cutting planes. Finally, operational environment testing underscored the pipeline's efficiency. More than half of the processed cases complied with the PSI prototyping requirements, reducing the overall time from 35 min to 13.1 s, while the remaining ones underwent a manual refinement step to achieve such PSI requirements, performing the procedure four to eleven times faster than the manufacturer standards. To conclude, this research advocates the need for real-world applicability and optimization of AI solutions in orthopedic surgical practice.

A Hierarchical Graph V-Net With Semi-Supervised Pre-Training for Histological Image Based Breast Cancer Classification.

Numerous patch-based methods have recently been proposed for histological image based breast cancer classification. However, their performance could be highly affected by ignoring spatial contextual information in the whole slide image (WSI). To address this issue, we propose a novel hierarchical Graph V-Net by integrating 1) patch-level pre-training and 2) context-based fine-tuning, with a hierarchical graph network. Specifically, a semi-supervised framework based on knowledge distillation is first developed to pre-train a patch encoder for extracting disease-relevant features. Then, a hierarchical Graph V-Net is designed to construct a hierarchical graph representation from neighboring/similar individual patches for coarse-to-fine classification, where each graph node (corresponding to one patch) is attached with extracted disease-relevant features and its target label during training is the average label of all pixels in the corresponding patch. To evaluate the performance of our proposed hierarchical Graph V-Net, we collect a large WSI dataset of 560 WSIs, with 30 labeled WSIs from the BACH dataset (through our further refinement), 30 labeled WSIs and 500 unlabeled WSIs from Yunnan Cancer Hospital. Those 500 unlabeled WSIs are employed for patch-level pre-training to improve feature representation, while 60 labeled WSIs are used to train and test our proposed hierarchical Graph V-Net. Both comparative assessment and ablation studies demonstrate the superiority of our proposed hierarchical Graph V-Net over state-of-the-art methods in classifying breast cancer from WSIs. The source code and our annotations for the BACH dataset have been released at https://github.com/lyhkevin/Graph-V-Net.

Stabilization of turbulence-degraded video using patch-based reference frame

Imaging over long distances in the atmosphere can result in significant degradation of the acquired videos due to atmospheric turbulence. This degradation can include problems such as blurring and geometric distortion, and it is challenging to correct these distortions because of their randomness in nature. To address this, a new method for improving the geometrical quality of video sequences of remote stationary scenes is introduced in this paper. The method uses a patch-based approach to obtain a reference frame from the distorted video sequence, selecting the best quality patches from different frames. A window-based image registration method is then used to estimate the geometrical shifts of the pixels, which are used to restore a high-quality frame. The proposed method is compared with two similar state-of-the-art video stabilization methods using experiments on both synthetic and real video sequences. Results demonstrate that the patch-based method outperforms the other methods in terms of accuracy.

Infrared Small-Target Detection Based on Background-Suppression Proximal Gradient and GPU Acceleration

Patch-based methods improve the performance of infrared small target detection, transforming the detection problem into a Low-Rank Sparse Decomposition (LRSD) problem. However, two challenges hinder the success of these methods: (1) The interference from strong edges of the background, and (2) the time-consuming nature of solving the model. To tackle these two challenges, we propose a novel infrared small-target detection method using a Background-Suppression Proximal Gradient (BSPG) and GPU parallelism. We first propose a new continuation strategy to suppress the strong edges. This strategy enables the model to simultaneously consider heterogeneous components while dealing with low-rank backgrounds. Then, the Approximate Partial Singular Value Decomposition (APSVD) is presented to accelerate solution of the LRSD problem and further improve the solution accuracy. Finally, we implement our method on GPU using multi-threaded parallelism, in order to further enhance the computational efficiency of the model. The experimental results demonstrate that our method out-performs existing advanced methods, in terms of detection accuracy and execution time.

Patch-based stochastic attention for image editing

Attention mechanisms have become of crucial importance in deep learning in recent years. These non-local operations, which are similar to traditional patch-based methods in image processing, complement local convolutions. However, computing the full attention matrix is an expensive step with heavy memory and computational loads. These limitations curb network architectures and performances, in particular for the case of high resolution images. We propose an efficient attention layer based on the stochastic algorithm PatchMatch, which is used for determining approximate nearest neighbors. We refer to our proposed layer as a “Patch-based Stochastic Attention Layer” (PSAL). Furthermore, we propose different approaches, based on patch aggregation, to ensure the differentiability of PSAL, thus allowing end-to-end training of any network containing our layer. PSAL has a small memory footprint and can therefore scale to high resolution images. It maintains this footprint without sacrificing spatial precision and globality of the nearest neighbors, which means that it can be easily inserted in any level of a deep architecture, even in shallower levels. We demonstrate the usefulness of PSAL on several image editing tasks, such as image inpainting, guided image colorization, and single-image super-resolution. Our code is available at: https://github.com/ncherel/psal.

A multi-method approach with machine learning to evaluating the distribution and intensity of prehistoric land use in Eastern Iberia

The present study seeks to better understand the coupling of social and biophysical systems during the late Pleistocene and Holocene, a period characterized by changing interglacial conditions as well as human population expansion and intensified ecosystem management. The approach consists of a combination of patch-based archaeological survey methods, sediment column sampling for paleoenvironmental data, geospatial analysis, and machine learning for chronological unmixing, allowing the systematic evaluation of the distribution and intensity of prehistoric land use in the study area of eastern Mediterranean Iberia. Occupational and Land Use Intensity maps developed from continuous distributions of surface artifacts as well as a summed probability density curve developed from 14C dates indicate low but steady human presence in the study area during the Middle Paleolithic and Upper Paleolithic with a marked decrease of human presence across the Pleistocene/Holocene boundary. The Early (and Middle) Neolithic saw the most ubiquitous and intensive occupation of the study area followed by a significant decline during the Late Neolithic/Chalcolithic. The charcoal analysis also supports this pattern. Early Neolithic farming strategies may not have been damaging initially during the climatic regime of the Early Holocene but exacerbated the impacts of higher temperatures and summer droughts, with a loss of the most productive farmland, seen at the onset of the Late Neolithic. Similar boom-bust population trends have been documented throughout Europe during these same time spans and may indicate a recursive interaction or “coupling” between global and regional climate events and human land use strategies.