An investigation on the nonlinear dynamic response and vibration of the imperfect laminated three-phase polymer nanocomposite panel resting on elastic foundations and subjected to hydrodynamic loads is presented in this paper. The formulations are based on the classical shell theory and stress function taking into account geometrical nonlinearity, initial geometrical imperfection and Pasternak type elastic foundation. Numerical results for dynamic response and vibration of the three-phase polymer composite panel are obtained by Runge–Kutta method. The influences of fibers and particles, material and geometrical properties, foundation stiffness, imperfection and hydrodynamic loads on the nonlinear dynamic response and nonlinear vibration of the three-phase composite panel are discussed in detail.