Past Field Trials Research Articles

Method matters: Understanding diagnostic reliability in DSM-IV and DSM-5.

Diagnostic reliability is essential for the science and practice of psychology, in part because reliability is necessary for validity. Recently, the DSM-5 field trials documented lower diagnostic reliability than past field trials and the general research literature, resulting in substantial criticism of the DSM-5 diagnostic criteria. Rather than indicating specific problems with DSM-5, however, the field trials may have revealed long-standing diagnostic issues that have been hidden due to a reliance on audio/video recordings for estimating reliability. We estimated the reliability of DSM-IV diagnoses using both the standard audio-recording method and the test-retest method used in the DSM-5 field trials, in which different clinicians conduct separate interviews. Psychiatric patients (N = 339) were diagnosed using the SCID-I/P; 218 were diagnosed a second time by an independent interviewer. Diagnostic reliability using the audio-recording method (N = 49) was "good" to "excellent" (M κ = .80) and comparable to the DSM-IV field trials estimates. Reliability using the test-retest method (N = 218) was "poor" to "fair" (M κ = .47) and similar to DSM-5 field-trials' estimates. Despite low test-retest diagnostic reliability, self-reported symptoms were highly stable. Moreover, there was no association between change in self-report and change in diagnostic status. These results demonstrate the influence of method on estimates of diagnostic reliability.

Evaluating Paradox Walnut Rootstocks for Resistance to Armillaria Root Disease

The most common rootstock for Juglans regia (Persian or “English” walnut) in California is Paradox, typically a hybrid of J. hindsii (Northern California black walnut) × J. regia. Unfortunately, Paradox is very susceptible to Armillaria root disease. The relative resistance to Armillaria mellea of six clonally propagated Paradox rootstocks (AX1, Px1, RR4 11A, RX1, Vlach, VX211) was evaluated and compared with that of clonally propagated J. hindsii rootstock selection W17, J. regia scion cultivar Chandler, and Pterocarya stenoptera (Chinese wingnut). In a growth-chamber assay, plants were micropropagated and rooted in vitro before inoculating the culture medium with A. mellea. At two months post-inoculation, the most resistant and susceptible Paradox rootstocks were AX1 and VX211, respectively, with 9% vs. 70% mortality, and this finding was consistent across three isolates of A. mellea and three replicate experiments. This broad range of resistance within Paradox is consistent with past field trials that tested other genotypes. Our finding of similarly high susceptibility of ‘Chandler’ and W17 (61% vs. 69% mortality) is in contrast to two field trials, in which other J. regia genotypes were more susceptible than those of J. hindsii. A third trial, however, identified some J. regia genotypes as more resistant than those of J. hindsii. Therefore, it is possible that W17, which was not previously tested, is an Armillaria-susceptible genotype of J. hindsii. Based on our findings of repeatable mortality levels across three isolates of A. mellea and three replicate experiments, the growth-chamber assay has promise, albeit with confirmed resistant and susceptible controls, for identifying putative resistant rootstocks (e.g., AX1) in preparation for a field trial with controlled inoculations.

Modelling and simulation of explosions in soil interacting with deformable structures

Abstract A detonating explosive interacting with a deformable structure is a highly transient and non-linear event. In field blast trials of military vehicles, a standard procedure is often followed in order to reduce the uncertainties and increase the quality of the test. If the explosive is buried in the ground, the state of the soil must meet specific demands. In the present work, laboratory experiments have been performed to characterize the behaviour of a soil material. Soil may be considered a three-phase medium, consisting of solid grains, water and air. Variations between the amounts of these phases affect the mechanical properties of the soil. The experimental outcome has formed input data to represent the soil behaviour included in a three-phase elastic-plastic cap model. This unified constitutive model for soil has been used for numerical simulations representing field blast trials, where the explosive load is interacting with a deformable structure. The blast trials included explosive buried at different depths in wet or dry sand. A dependence of the soil initial conditions can be shown, both in the past field trials along with the numerical simulations. Even though some deviations exist, the simulations showed in general acceptable agreement with the experimental results.

Clinical staging of cancer of the head and neck: A new “new” system

A revised clinical staging system for cancers arising in head and neck sites has been prepared. It utilizes a uniform N classification for cervical node metastases. The T classifications describing the extent of the primary tumor are generally similar but differ in specific details for each site. Although the present system makes use of past field trials and more recent clinical studies, it cannot be considered final. Clinicians managing cancer in head and neck sites are encouraged to test the system with their own patient data to elicit further areas for improvement.

Bioassay of a nuclear-polyhedrosis virus and Bacillus thuringiensis against the American bollworm, Heliothis armigera, in Botswana

Heliothis armigera is a serious pest in Botswana. Preparations of a local nuclear-polyhedrosis virus and Bacillus thuringiensis (Biotrol BTB-183) are being considered as treatments for control of this pest. Laboratory bioassays of these two preparations were carried out to provide a firm basis for comparison with past field trials and a standard for future field testing. The LC 50 of the virus and LD 50 of B. thuringiensis were found to compare favorably with those for similar materials against closely and distantly related lepidopterous pests. The majority of larvae were killed very rapidly by the B. thuringiensis, although some survived up to 14 days before death. The minimum time to mortality for the virus was 4 days. B. thuringiensis lowered the weight of both male and female surviving pupae, whereas the virus had no significant effect on its survivors. Concentrations of the two materials calculated from the LC 90 and LD 90 were considerably lower than those already found to give some or good control of H. armigera on sorghum. Improved spray coverage and protection of the materials against environmental degradation are required if spraying concentrations are to be reduced and yet remain effective.

Factors affecting Arabica coffee bean size in Kenya

SummaryThe proportion of large, commercially valuable coifee beans (6.75 mm sieve) varies greatly within and between years in Kenya and is altered by field treatments which affect the water status, seasonal fruiting pattern and yield of the trees.Defoliation trials suggested that little of this variation could be attributed to changes in assimilate supply during fruit development, although these could explain differences in the weight of the fruit pericarps. The largest differences in bean size recorded in past field trials at Ruiru were associated with differences in rainfall, and presumably tree water status, while the fruits expanded; the ovules did not reach full size when they expanded during dry weather.These conclusions are discussed in relation to the selective pressures that may operate in coffee’s native forest understorey environment, and its tendency to ‘overbear’ in unshaded plantations.