The ride comfort is a key research area for the quality improvement of railway vehicles. Several control methods have been developed to improve the ride comfort, in which the semi-active control approach inherits the advantages of passive and active control approaches. However, the semi-active control may perform ineffectively in vibration attenuation when the carbody load changes. To address this issue, we proposed a novel hybrid control method that combines the skyhook (SH) and displacement velocity (DV) control methods to reduce vibrations of the carbody in the lateral direction under carbody load changes. First, a hybrid control model built in Matlab software was applied to a quarter railway vehicle model for a preliminary assessment of the ride comfort. Second, to provide a more comprehensive evaluation, the proposed model was applied to a whole railway vehicle model using co-simulation (Matlab-Simpack). In the quarter model, under the sinusoidal excitation, the hybrid control showed a lower acceleration by 48.5% and 42.8% when the carbody load reduced to a half and a quarter, respectively, compared to the passive control. This finding was confirmed with the whole model. Moreover, in the whole model, under the track irregular excitation, the hybrid control showed a lower acceleration by 26.6% and 17.4% when the carbody load reduced to a half and a quarter, respectively. Further, the proposed method showed an acceptable safety level, measured by the derailment coefficient (0.0743 at a half load and 0.089 at a quarter load). In conclusions, the proposed hybrid SH-DV control exhibits high robustness, adaptability, effectiveness, and acceptable safety level in response to variations in body load.