Enhanced diffusion coefficients arising from the theory of periodic homogenized averaging for a passive scalar diffusing in the presence of a large-scale, fluctuating mean wind superimposed upon a small-scale, steady flow with non-trivial topology are studied. The purpose of the study is to assess how the extreme sensitivity of enhanced diffusion coefficients to small variations in large-scale flow parameters previously exhibited for steady flows in two spatial dimensions is modified by either the presence of temporal fluctuation, or the consideration of fully three-dimensional steady flow. We observe the various mixing parameters (Péclet, Strouhal and periodic Péclet numbers) and related non-dimensionalizations. We document non-monotonic Péclet number dependence in the enhanced diffusivities, and address how this behaviour is camouflaged with certain non-dimensional groups. For asymptotically large Strouhal number at fixed, bounded Péclet number, we establish that rapid wind fluctuations do not modify the steady theory, whereas for asymptotically small Strouhal number the enhanced diffusion coefficients are shown to be represented as an average over the steady geometry. The more difficult case of large Péclet number is considered numerically through the use of a conjugate gradient algorithm. We consider Péclet-number-dependent Strouhal numbers, S = QPe−(1+γ), and present numerical evidence documenting critical values of γ which distinguish the enhanced diffusivities as arising simply from steady theory (γ < −1) for which fluctuation provides no averaging, fully unsteady theory (γ ∈ (−1, 0)) with closure coefficients plagued by non-monotonic Péclet number dependence, and averaged steady theory (γ > 0). The transitional case with γ = 0 is examined in detail. Steady averaging is observed to agree well with the full simulations in this case for Q [les ] 1, but fails for larger Q. For non-sheared flow, with Q [les ] 1, weak temporal fluctuation in a large-scale wind is shown to reduce the sensitivity arising from the steady flow geometry; however, the degree of this reduction is itself strongly dependent upon the details of the imposed fluctuation. For more intense temporal fluctuation, strongly aligned orthogonal to the steady wind, time variation averages the sensitive scaling existing in the steady geometry, and the present study observes a Pe1 scaling behaviour in the enhanced diffusion coefficients at moderately large Péclet number. Finally, we conclude with the numerical documentation of sensitive scaling behaviour (similar to the two-dimensional steady case) in fully three dimensional ABC flow.