Passive Oddball Paradigm Research Articles

Neural responses in novice learners’ perceptual learning and generalization of lexical tones: The effect of training variability

The acoustics of lexical tones are highly variable across talkers, and require second-language (L2) learners’ flexibility in accommodating talker-specific tonal variations for successful learning. This study investigated how tone training with high vs. low talker-variability modulated novice learners’ neural responses to non-native tones. A passive oddball paradigm tested Mandarin-speaking participants’ neural responses to Cantonese low–high and low-mid tonal contrasts in the pretest and posttest. Participants were trained using a tone identification task with feedback, either with high or low talker-variability. The results of mismatch negativity (MMN) showed no group difference in the pretest whereas the high-variability group demonstrated greater neural sensitivity to the low–high tonal contrast produced by a novel talker and a trained talker in the posttest. The finding provides (tentative) novel evidence that training variability may benefit perceptual learning of the relatively easy tone pair and facilitate the formation of talker-independent representations of non-native tones by novice learners.

Right Hemisphere Lateralization of Character Transposition Processing: Evidence From Early N1 Response

The acoustics of lexical tones are highly variable across talkers, and require second-language (L2) learners’ flexibility in accommodating talker-specific tonal variations for successful learning. This study investigated how tone training with high vs. low talker-variability modulated novice learners’ neural responses to non-native tones. A passive oddball paradigm tested Mandarin-speaking participants’ neural responses to Cantonese low–high and low-mid tonal contrasts in the pretest and posttest. Participants were trained using a tone identification task with feedback, either with high or low talker-variability. The results of mismatch negativity (MMN) showed no group difference in the pretest whereas the high-variability group demonstrated greater neural sensitivity to the low–high tonal contrast produced by a novel talker and a trained talker in the posttest. The finding provides (tentative) novel evidence that training variability may benefit perceptual learning of the relatively easy tone pair and facilitate the formation of talker-independent representations of non-native tones by novice learners.

Psychomotor Speed Predicts Outcome in Patients with Acute Meningitis and Encephalitis: A Prospective Observational Study

Background and Purpose. Although acute meningitis and encephalitis are known to cause cognitive dysfunction, the prognostic values of neuropsychological and neurophysiological tests in predicting clinical outcomes are seldom studied. We investigated specific neurocognitive dysfunction and event-related potentials (ERPs), which can predict functional outcomes in patients with acute meningitis and encephalitis. Methods. We enrolled consecutive adult patients with acute meningitis and encephalitis and performed neuropsychological tests and ERP studies using a passive auditory oddball paradigm at enrollment. Patient functional outcomes were assessed using the Glasgow Outcome Scale at 6 (GOS6) months after discharge. Results. Twenty-two patients were included in the study. Among 21 patients who performed neuropsychological tests, Korean-Trail Making Test-Elderly's version, Part A time (TMT-A time) correlated with GOS6, which remained significant even after controlling for age. We identified a significant association between TMT-A time and P3a latency. Post-hoc analysis showed that patients with longer TMT-A time (≥23 s) tended to have longer P3a latency than those with shorter TMT-A time. Conclusions. Decreased psychomotor speed predicted poor clinical outcomes. Because TMT-A time can be performed at the bedside in a relatively short time, this might be a useful neuropsychological biomarker to predict or monitor clinical outcomes. Furthermore, passive oddball P3a may be useful in patients with more severe disease who are unable to perform the TMT task.

Contrast and Conflict in Dutch Vowels.

The nature of phonological representations has been extensively studied in phonology and psycholinguistics. While full specification is still the norm in psycholinguistic research, underspecified representations may better account for perceptual asymmetries. In this paper, we report on a mismatch negativity (MMN) study with Dutch listeners who took part in a passive oddball paradigm to investigate when the brain notices the difference between expected and observed vowels. In particular, we tested neural discrimination (indicating perceptual discrimination) of the tense mid vowel pairs /o/-/ø/ (place contrast), /e/-/ø/ (labiality or rounding contrast), and /e/-/o/ (place and labiality contrast). Our results show (a) a perceptual asymmetry for place in the /o/-/ø/ contrast, supporting underspecification of [CORONAL] and replicating earlier results for German, and (b) a perceptual asymmetry for labiality for the /e/-/ø/ contrast, which was not reported in the German study. A labial deviant [ø] (standard /e/) yielded a larger MMN than a deviant [e] (standard /ø/). No asymmetry was found for the two-feature contrast. This study partly replicates a similar MMN study on German vowels, and partly presents new findings indicating cross-linguistic differences. Although the vowel inventory of Dutch and German is to a large extent comparable, their (morpho)phonological systems are different, which is reflected in processing.

Cantonese advantage on English stress perception: Constraints and neural underpinnings

A prevailing conception of cross-linguistic transfer is that first language experience poses perceptual interference, or at best null effect, on second language speech perception. Surprisingly, a recent study found that Cantonese listeners outperformed English listeners on English stress perception. The present study further evaluated whether segmental variations would constrain the Cantonese advantage on English stress perception. Cantonese and English listeners were tested with both active and passive oddball paradigms in which ERP responses to English stress deviations were elicited. Behaviorally, the Cantonese listeners exhibited a perceptual advantage relative to the English listeners, but this advantage disappeared upon the introduction of segmental variations. Neurophysiologically, segmental variations diminished the P3b amplitudes of the Cantonese but not the English listeners. Collectively, results suggest that segmental variations constrain the Cantonese advantage on English stress perception.

Phonological Variations Are Compensated at the Lexical Level: Evidence From Auditory Neural Activity.

Dealing with phonological variations is important for speech processing. This article addresses whether phonological variations introduced by assimilatory processes are compensated for at the pre-lexical or lexical level, and whether the nature of variation and the phonological context influence this process. To this end, Swedish nasal regressive place assimilation was investigated using the mismatch negativity (MMN) component. In nasal regressive assimilation, the coronal nasal assimilates to the place of articulation of a following segment, most clearly with a velar or labial place of articulation, as in utan mej “without me” > [ʉːtam mɛjː]. In a passive auditory oddball paradigm, 15 Swedish speakers were presented with Swedish phrases with attested and unattested phonological variations and contexts for nasal assimilation. Attested variations – a coronal-to-labial change as in utan “without” > [ʉːtam] – were contrasted with unattested variations – a labial-to-coronal change as in utom “except” > ∗[ʉːtɔn] – in appropriate and inappropriate contexts created by mej “me” [mɛjː] and dej “you” [dɛjː]. Given that the MMN amplitude depends on the degree of variation between two stimuli, the MMN responses were expected to indicate to what extent the distance between variants was tolerated by the perceptual system. Since the MMN response reflects not only low-level acoustic processing but also higher-level linguistic processes, the results were predicted to indicate whether listeners process assimilation at the pre-lexical and lexical levels. The results indicated no significant interactions across variations, suggesting that variations in phonological forms do not incur any cost in lexical retrieval; hence such variation is compensated for at the lexical level. However, since the MMN response reached significance only for a labial-to-coronal change in a labial context and for a coronal-to-labial change in a coronal context, the compensation might have been influenced by the nature of variation and the phonological context. It is therefore concluded that while assimilation is compensated for at the lexical level, there is also some influence from pre-lexical processing. The present results reveal not only signal-based perception of phonological units, but also higher-level lexical processing, and are thus able to reconcile the bottom-up and top-down models of speech processing.

Asymmetric Influence of Vocalic Context on Mandarin Sibilants: Evidence From ERP Studies.

In the present study, we examine the interactive effect of vowels on Mandarin fricative sibilants using a passive oddball paradigm to determine whether the HEIGHT features of vowels can spread on the surface and influence preceding consonants with unspecified features. The stimuli are two pairs of Mandarin words ([sa] ∼ [ʂa] and [su] ∼ [ʂu]) contrasting in vowel HEIGHT ([LOW] vs. [HIGH]). Each word in the same pair was presented both as standard and deviant, resulting in four conditions (/standard/[deviant]: /sa/[ʂa] ∼ /ʂa/[sa] and /su/[ʂu] ∼ /ʂu/[su]). In line with the Featurally Underspecified Lexicon (FUL) model, asymmetric patterns of processing were found in the [su] ∼ [ʂu] word pair where both the MMN (mismatch negativity) and LDN (late discriminative negativity) components were more negative in /su/[ʂu] (mismatch) than in /ʂu/[su] (no mismatch), suggesting the spreading of the feature [HIGH] from the vowel [u] to [ʂ] on the surface. In the [sa] ∼ [ʂa] pair, however, symmetric negativities (for both MMN and LDN) were observed as there is no conflict between the surface feature [LOW] from [a] to [ʂ] and the underlying specified feature [LOW] of [s]. These results confirm that not all features are fully specified in the mental lexicon: features of vowels can spread on the surface and influence surrounding unspecified segments.

Working memory contributes to word stress processing in a fixed-stress language

ABSTRACT The role of working memory (WM) has been evidenced in language processing; however, the contribution of WM to the detection of linguistic deviance has remained unclear. This study aimed to examine how WM performance influences the detection of prosodic deviance in a fixed-stress language, which is supposed to be determined by a long-term word stress template. Therefore, Mismatch Negativity (MMN) event-related potentials (ERPs) were recorded during a passive oddball paradigm containing pseudowords with two different stress patterns, legal and illegal. Besides, complex WM tasks (Counting span task, Verbal fluency tasks) were administered. Results revealed that greater WM performance measured by the Counting span task was associated with smaller MMN response for the legally-stressed stimuli but with larger MMN response for the illegally-stressed stimuli. Altogether, our ERP results suggest that WM has a general role in the processing of the native fixed word stress.

Mismatch negativity and P3a in drug-naive adults with attention-deficit hyperactivity disorder.

Individuals with attention-deficit hyperactivity disorder (ADHD) often display over-response to stimuli that are irrelevant to the ongoing task, and their attentional abilities disproportionately worsen in the presence of competing stimuli. Auditory event-related potentials (ERPs) such as mismatch negativity (MMN) and P3a using the passive oddball paradigm have been studied in children and adolescents with ADHD. Still, there is no such data for adults with ADHD. This study aimed to compare the MMN and P3a and their clinical and neurocognitive correlations between drug-naive adults with ADHD and control adults. We recruited 52 adults with ADHD (26.5 ± 6.2 years), and 62 age-matched controls (25.6 ± 5.6 years). They received the psychiatric interviews, auditory ERP, the Conners' continuous performance test (CCPT), and the Cambridge gambling test (CGT). They also completed the questionnaires about ADHD symptoms and real-world executive functions. MMN and P3a were assessed during a passive duration-deviant auditory oddball paradigm from the midline electrodes Cz. Adults with ADHD demonstrated smaller Cz MMN amplitude, more severe ADHD symptoms, poorer attention profiles (CCPT), and a wide range of executive dysfunctions than controls. As for the correlates, Cz peak amplitude of MMN correlated with inattention symptoms, executive dysfunctions, attentional vigilance (CCPT), and decision-making (CGT) in ADHD adults but only with decision-making in controls. Our findings that smaller amplitude of MMN and its differential associated pattern with inattention, real-world executive dysfunction, and decision-making, in drug-naive adults with ADHD from adult controls, provide evidence to support the potential electrophysiological biomarker for adult ADHD.

Target detection in healthy 4-week old piglets from a passive two-tone auditory oddball paradigm

BackgroundPassive auditory oddball tests are effort independent assessments that evaluate auditory processing and are suitable for paediatric patient groups. Our goal was to develop a two-tone auditory oddball test protocol and use this clinical assessment in an immature large animal model. Event-related potentials captured middle latency P1, N1, and P2 responses in 4-week old (N = 16, female) piglets using a custom piglet 32- electrode array on 3 non-consecutive days. The effect of target tone frequency (250 Hz and 4000 Hz) on middle latency responses were tested in a subset of animals.ResultsResults show that infrequent target tone pulses elicit greater N1 amplitudes than frequent standard tone pulses. There was no effect of day. Electrodes covering the front of the head tend to elicit greater waveform responses. P2 amplitudes increased for higher frequency target tones (4000 Hz) than the regular 1000 Hz target tones (p < 0.05).ConclusionsTwo-tone auditory oddball tests produced consistent responses day-to-day. This clinical assessment was successful in the immature large animal model.

The effects of an internet-based mindfulness meditation intervention on electrophysiological markers of attention

Evidence suggests that mindfulness meditation training has the potential to train aspects of attention. However, the neurophysiological mechanisms underpinning the attentional benefits from mindfulness remain unclear. This randomized controlled trial examined changes in electrophysiological markers of attention before and after completion of a 6-week internet-based mindfulness intervention. EEG and ERP data were collected from 64 generally healthy, mildly stressed older adults. Participants were randomized to an internet-based mindfulness-based stress reduction course (IMMI), an internet-based health and wellness education course, or a waitlist control condition. Attentional N2 and P3 evoked potentials were derived from active and passive auditory oddball paradigms.Participants in the IMMI group showed significantly greater differences in P3 peak-trough amplitude between the active and passive oddball paradigms at endpoint relative to controls. There were no significant relationships between the intervention and N2 potentials. Our data demonstrate a measurable increase in attentional control when discriminating or directing attention away from auditory stimuli for older adult participants who received mindfulness training. These findings lend support to the use of the P3 as a neurophysiological measure of meditation engagement and intervention efficacy.

Source localization of tone perception in alcoholic brain indexed by standardized low-resolution electromagnetic tomography

&lt;p&gt;Alcohol consumption is known to associate with several diseases, injuries, and social problems. The long-term, excessive alcohol exposure can lead to liver cirrhosis and pancreatitis. After repating alcohol exposure, alcohol dependence would develop an individually behavioral, cognitive, and physiological phenomenon. Previous studies indicated that although the left hemisphere was selectively employed for processing linguistic information irrespectively of acoustic cues or subtype of phonological unit, the right hemisphere was employed for prosody-specific cues. These previous studies provided the impetus for future investigations of tone perception and temporal integration differences in tonal brain speaker who had long-term, excessive alcohol exposure such as Thai in the present study. The present study used both an auditory mismatch negativity (MMN) component of event-related potentials (ERPs) recording and the standardized Low-resolution Electromagnetic Tomography (sLORETA) techniques to measure the degree of cortical activation and to localize the brain area contributing to the scalp recorded auditory MMN component during the passive oddball paradigm. Ten healthy right-handed adults participated in this study. The findings showed that both [kha:] - mid tone perception and [khá:] - high tone perception elicited a strong MMN between 215-284 ms with reference to the standard-stimulus ERPs. Source localization was obtained in the middle temporal gyrus of the right hemisphere for both [kha:] - mid tone perception and [khá:] - high tone perception. Automatic detection of tone perception in alcoholic tonal brain is a useful index of language universal auditory memory traces.&lt;/p&gt;

A Neurophysiological Study of Musical Pitch Identification in Mandarin-Speaking Cochlear Implant Users.

Music perception in cochlear implant (CI) users is far from satisfactory, not only because of the technological limitations of current CI devices but also due to the neurophysiological alterations that generally accompany deafness. Early behavioral studies revealed that similar mechanisms underlie musical and lexical pitch perception in CI-based electric hearing. Although neurophysiological studies of the musical pitch perception of English-speaking CI users are actively ongoing, little such research has been conducted with Mandarin-speaking CI users; as Mandarin is a tonal language, these individuals require pitch information to understand speech. The aim of this work was to study the neurophysiological mechanisms accounting for the musical pitch identification abilities of Mandarin-speaking CI users and normal-hearing (NH) listeners. Behavioral and mismatch negativity (MMN) data were analyzed to examine musical pitch processing performance. Moreover, neurophysiological results from CI users with good and bad pitch discrimination performance (according to the just-noticeable differences (JND) and pitch-direction discrimination (PDD) tasks) were compared to identify cortical responses associated with musical pitch perception differences. The MMN experiment was conducted using a passive oddball paradigm, with musical tone C4 (262 Hz) presented as the standard and tones D4 (294 Hz), E4 (330 Hz), G#4 (415 Hz), and C5 (523 Hz) presented as deviants. CI users demonstrated worse musical pitch discrimination ability than did NH listeners, as reflected by larger JND and PDD thresholds for pitch identification, and significantly increased latencies and reduced amplitudes in MMN responses. Good CI performers had better MMN results than did bad performers. Consistent with findings for English-speaking CI users, the results of this work suggest that MMN is a viable marker of cortical pitch perception in Mandarin-speaking CI users.

MEG reveals preference specific increases of sexual-image-evoked responses in paedophilic sexual offenders and healthy controls

Objectives Paedophilic disorder is characterised by sexual attraction towards children. Classification of a counterpart as sexually attractive likely occurs rapidly, and involves both conscious and unconscious attentional and cognitive processes. Magnetoencephalography (MEG) is an imaging method especially well-suited to examine visual and attentional processes triggered by sexual images within the range of milliseconds. Methods We investigated brain responses to sexual images depicting adults (frequent) and children (infrequent stimulus) in seventeen paedophilic patients with a history of child sexual offending (P + CSO) and twenty healthy controls (HC) during a passive visual oddball paradigm. Event-related fields (ERF) were measured to extract the magnetic visual mismatch negativity (vMMNm), and how it relates to the processing of different classes of sexual stimuli. Results P + CSO exhibited significantly longer vMMNm latencies (100–180 ms post-stimulus) than HC. Moreover, P + CSO showed widespread increased amplitudes in response to child images starting from P3a and P3b components and lasting up to 400 ms post-stimulus presentation localised in frontal and temporal brain regions. Conclusions This study uncovers the first MEG differences in automatic change detection between P + CSO and HC during the presentation of subliminal sexual images of adults and children, contributing towards a better understanding of the neurobiological processes of P + CSO.

Cortical Characterization of Reverberation Time in Reverberant Speech.

Reverberation reduces speech quality, and therefore causes inconveniency to listeners, especially those using assistive hearing devices. To enhance the quality of reverberant speech, a significant step is speech quality assessment, most of which are based on subjective judgements. Subjective evaluations vary with listeners' perception, emotional and mental states. To obtain an objective assessment of speech quality in reverberation, this work carried out an event related potential (ERP) study using a passive oddball paradigm. Listeners were presented with anechoic speech as standard stimuli mixed with reverberant speech under different levels of reverberation as deviant stimuli. The ERP responses reveal how human-beings' subconsciousness interacts with different levels of reverberation in the perceived speech. Results showed that the peak amplitude of P300 in ERP responses followed the variation of reverberation time in reverberant speech, providing evidence that P300 in ERP responses could work as a neural surrogate of reverberation time in objective speech quality assessment.

ERP mismatch response to phonological and temporal regularities in speech

Predictions of our sensory environment facilitate perception across domains. During speech perception, formal and temporal predictions may be made for phonotactic probability and syllable stress patterns, respectively, contributing to the efficient processing of speech input. The current experiment employed a passive EEG oddball paradigm to probe the neurophysiological processes underlying temporal and formal predictions simultaneously. The component of interest, the mismatch negativity (MMN), is considered a marker for experience-dependent change detection, where its timing and amplitude are indicative of the perceptual system’s sensitivity to presented stimuli. We hypothesized that more predictable stimuli (i.e. high phonotactic probability and first syllable stress) would facilitate change detection, indexed by shorter peak latencies or greater peak amplitudes of the MMN. This hypothesis was confirmed for phonotactic probability: high phonotactic probability deviants elicited an earlier MMN than low phonotactic probability deviants. We do not observe a significant modulation of the MMN to variations in syllable stress. Our findings confirm that speech perception is shaped by formal and temporal predictability. This paradigm may be useful to investigate the contribution of implicit processing of statistical regularities during (a)typical language development.

Neural Correlates of Modality-Sensitive Deviance Detection in the Audiovisual Oddball Paradigm.

The McGurk effect, an incongruent pairing of visual /ga/–acoustic /ba/, creates a fusion illusion /da/ and is the cornerstone of research in audiovisual speech perception. Combination illusions occur given reversal of the input modalities—auditory /ga/-visual /ba/, and percept /bga/. A robust literature shows that fusion illusions in an oddball paradigm evoke a mismatch negativity (MMN) in the auditory cortex, in absence of changes to acoustic stimuli. We compared fusion and combination illusions in a passive oddball paradigm to further examine the influence of visual and auditory aspects of incongruent speech stimuli on the audiovisual MMN. Participants viewed videos under two audiovisual illusion conditions: fusion with visual aspect of the stimulus changing, and combination with auditory aspect of the stimulus changing, as well as two unimodal auditory- and visual-only conditions. Fusion and combination deviants exerted similar influence in generating congruency predictions with significant differences between standards and deviants in the N100 time window. Presence of the MMN in early and late time windows differentiated fusion from combination deviants. When the visual signal changes, a new percept is created, but when the visual is held constant and the auditory changes, the response is suppressed, evoking a later MMN. In alignment with models of predictive processing in audiovisual speech perception, we interpreted our results to indicate that visual information can both predict and suppress auditory speech perception.

Consciousness modulates the automatic change detection of masked emotional faces: Evidence from visual mismatch negativity

The ability to automatically detect changes in the environment is crucial for organisms to survive. In the visual system, changes in visual stimuli may evoke visual mismatch negativity (vMMN), an event-related potential (ERP) component that reflects automatic change detection. Previous studies that used visual masking to examine the effects of consciousness did not yield evidence that vMMN could be elicited by subliminal stimuli. However, these studies used relatively simple visual features. To further examine the role of consciousness in vMMN, the present study used emotional (happy and fearful) faces, which are biologically and socially significant visual stimuli. A passive oddball paradigm was employed, and we found that only fearful faces could evoke vMMN at a low consciousness level. Furthermore, the fear-related vMMN was enhanced by the consciousness level, and localized in regions of the brain associated with emotional face processing and the prefrontal cortex. We also found that the emotional visual mismatch oscillatory responses (vMORs) were associated with the enhancement of the alpha-band oscillation. Moreover, consciousness could weaken the happiness-related vMOR. These results suggested that changes to emotional faces—especially fearful faces—could be unconsciously detected by the brain. More importantly, this automatic change detection mechanism could be modulated by consciousness.

EEG Effective Source Projections Are More Bilaterally Symmetric in Infants Than in Adults

Although anatomical brain hemispheric asymmetries have been clearly documented in the infant brain, findings concerning functional hemispheric specialization have been inconsistent. The present report aims to assess whether bilaterally symmetric synchronous activity between the two hemispheres is a characteristic of the infant brain. To asses cortical bilateral synchronicity, we used decomposition by independent component analysis (ICA) of high-density electroencephalographic (EEG) data collected in an auditory passive oddball paradigm. Decompositions of concatenated 64-channel EEG data epochs from each of 34 typically developing 6-month-old infants and from 18 healthy young adults participating in the same passive auditory oddball protocol were compared to characterize differences in functional brain organization between early life and adulthood. Our results show that infant EEG decompositions comprised a larger number of independent component (IC) effective source processes compatible with a cortical origin and having bilaterally near-symmetric scalp projections (13.8% of the infant data ICs presented a bilateral pattern vs. 4.3% of the adult data ICs). These IC projections could be modeled as the sum of potentials volume-conducted to the scalp from synchronous locally coherent field activities in corresponding left and right cortical source areas. To conclude, in this paradigm, source-resolved infant brain EEG exhibited more bilateral synchronicity than EEG produced by the adult brain, supporting the hypothesis that more strongly unilateral and likely more functionally specialized unihemispheric cortical field activities are concomitants of brain maturation.

The effect of hand motion and object orientation on the automatic detection of orientation: A visual mismatch negativity study.

We investigated the effects of voluntary hand movements and continuously present objects on the automatic detection of deviant stimuli in a passive oddball paradigm. The visual mismatch negativity (vMMN) component of event-related potentials (ERPs) was measured as the index of automatic deviant detection. The stimuli were textures consisting of parallel, oblique bars with frequent (standard) and infrequent (deviant) orientation. Traditional vMMN was measured by the difference between ERPs to frequent (standard) and infrequent (deviant) textures. Additionally, we measured ‘genuine’ vMMN by comparing the ERPs to deviant and control textures in the equal probability procedure. Compatible and incompatible hand movement directions to the standard texture had no influence on ‘traditional’ vMMN and elicited no ‘genuine’ vMMN. However, the deviant texture elicited ‘genuine’ vMMN if the orientation of a continuously present rectangle was different from the standard (and identical to the deviant) texture orientation. Our results suggest that the direction of voluntary hand movement and the orientation of task-irrelevant visual patterns do not acquire common memory representation, but a continuously present object contributes to the detection of sequential regularity violation.