Virechana is among the Pancha Shodhana and Panchakarma, as explained by Acharyas in the classics. Virechana is the procedure in which the orally administered Dravyas act on internally vitiated Doshas, specifically Pitta, and expels them through Gudamarga. Psoriasis is a chronic, recurrent, inflammatory disease of the skin of unknown origin, characterised by well-circumscribed erythematous, dry plaques of various sizes covered with scales. The Prevalence of Psoriasis varies across countries, ranging from 0.09-11.43%. Globally, it is estimated that at least 100 million individuals are affected by Psoriasis. In India, the reported incidence varies from 0.44- 2.8% among skin disorders, with an overall incidence of 1.02%. In Ayurveda, various skin diseases are classified under the broad category of Kushta. Features of Psoriasis resemble multiple types of Kushta. Hence, this clinical study of Virechana with Triphaladi Choorna was taken to assess its efficacy in this disease. The assessment used parameters like PASI Score, Auspitz sign, and Candle grease sign. Objectives: To evaluate the effect of Virechana with Triphaladi Choorna in the management of Psoriasis. Methods: This is an open-label clinical study with pre-test and post-test design wherein 20 patients diagnosed with Psoriasis and fulfilling the selection criteria in the age group of 18 – 70 years of either gender were selected from the OPD/IPD. Results: The study showed a statistically significant result in decrement in PASI Score with a change from before treatment to after follow-up. Interpretation and Conclusion: Hence, Virechana Karma with Triphaladi Choorna was found to be effective in reducing signs and symptoms of Psoriasis