Research has shown that people with disabilities (PWD) face ableism, which is associated with their social exclusion. Based on the existing literature regarding the social exclusion of PWD, we hypothesized for the current study that higher education levels, personal experiences with PWD, and openness would reduce ableism and negative attitudes of PWD and increase the social inclusion of PWD. Additionally, we hypothesized that a negative correlation would exist between social inclusion of PWD and ableism and negative attitudes of PWD, moderated by the personality trait openness. Participants consisted of adults (N = 364) who identified as mostly White, female, and nondisabled, and were asked to complete an electronic survey consisting of 4 pre-existing scales measuring ableism, negative attitudes of PWD, social inclusion, and openness. The data were analyzed using regression analyses, t tests, ANOVAs, and moderation analyses. The results showed that higher education levels (R2 = .02) and personal experiences with PWD (d = –0.35) predicted lower ableism. Additionally, more openness predicted more social inclusion (R2 = .03), less ableism (R2 = .14), and higher completed levels of education (R2 = .06). Further, voting for conservative political party candidates predicted higher levels of ableism (R2 = .11), and voting for liberal political party candidates predicted lower levels of ableism (R2 = .13). Although this study had some limitations, it highlights the importance of education and openness in reducing ableism and increasing the social inclusion of PWD.