Coronavirus disease 2019 (COVID-19) has bring disastrous impact to people globally. The United States has been among the most affected. COVID-19 and vaccine decision have evolved to a hotly debated topic among American public, as well as Democratic and Republican politicians. While ample research has been conducted on how politicians shape public opinion and behavior, only a few have dive deeper into the specific influence of Democratic and Republican politicians on public views regarding COVID-19 and vaccine decisions. This paper aims to evaluate the impact from these politicians by analyzing the previous research on partisanship, political theory, public opinion and behavior. The paper finds out that contrasting party ideology between Democratic and Republican politicians contribute to differing vaccine decisions. The paper also pinpoints party affiliation as a factor influencing people’s opinion on COVID-19 and vaccine decision. In response, the paper proposes public awareness campaign by NGOs to address the influence of party ideology; promotes bipartisan dialogue and collaboration on COVID-19 to mitigate the effect of party affiliation. Both Democratic and Republican politicians must work together to minimize the political perception of COVID, ensuring it remains a health decision.