The fracture of sandstone is closely related to the condition of internal microcracks and the fabric of micrograin. The macroscopic mechanical property depends on its microscopic structures. However, it is difficult to obtain the law of the microcrack growth under loading by experiments. A series of microscopic sandstone models were established with particle flow code 3D (PFC3D) and based on the triaxial experiment results on sandstones. The experimental and numerical simulations of natural and saturated sandstones under different confining pressures were implemented. We analyzed the evolution of rock deformation and the rock fracture development from a microscopic view. Results show that although the sandstones are under different confining pressures, the law of microcrack growth is the same. That is, the number of the microcracks increases slowly in the initial stage and then increases exponentially. The number of shear cracks is more than the tensile cracks, and the proportion of the shear cracks increases with the increase of confining pressure. The cracking strength of natural and saturated sandstones is 26% and 27% of the peak strength, respectively. Under low confining pressure, the total number of cracks in the saturated sample is 20% more than that of the natural sample and the strongly scattered chain is barely seen. With the increase of the confining pressure, the effect of water on the total number of cracks is reduced and the distribution of the strong chain is even more uniform. In other words, it is the confining pressure that mainly affects the distribution of the force chain, irrespective of the state of the rock, natural or saturated. The research results reveal that the control mechanism of shear crack friction under the different stress states of a rock slope in the reservoir area provides a basis for evaluating the stability of rock mass and predicting the occurrence of geological disasters.