Charged Particles Research Articles

Particle therapy in gastrointestinal cancer-a narrative review.

Radiation therapy is one of the main pillars in the treatment of gastrointestinal (GI) cancers, especially esophageal and anorectal malignancies. The worldwide standard of care is yet an irradiation with photons. Though not commonly used, charged particles offer some physical advantages with a highly conformal dose distribution, which allows an even better sparing of organs at risk. In addition to dosimetric advantages, heavy-ion beams like carbon ions may offer an additional set of biological advantages. Because particle therapy is not standard of care, data are scarce-especially concerning the use in GI malignancies. The aim of this review is to provide a compact overview of the currently available literature. PubMed and Web of Science databases were searched for publications on particle radiotherapy in GI cancer (e.g., proton therapy in esophageal cancer, carbon ion radiotherapy in pancreatic cancer). Here we present a review of the current data on particle therapy with regard to esophageal, pancreatic, hepatic and anorectal malignancies. Data on particle therapy in GI cancer are scarce. Nevertheless, the current literature shows some promising results. Further clinical evidence, especially randomized trials, is crucial to augment the role of particle radiotherapy in GI cancer.

Thrust Generation Through a Collimated Electron Beam in a Magnetic Mirror and its Possible Applications in Plasma Thrusters

In this article, we apply some basic concepts of electric thrusters, using Monte Carlo simulations. One such concept is the thrust, which we calculate for the simulated case of a simple thruster, consisting of two stages. The goal is to study the thrust in a magnetic bottle as a function of the collimation of an assembly of particles. In the first stage, a voltage applied between a pair of electrodes accelerates the particles. We perform simulations of the behavior of the assembly of charged particles. A normal distribution is used for the initial velocities of the assembly, with a given standard deviation. The resulting velocity distribution and its dependence on the applied voltage are analyzed. Further, the set of particles, whose pitch angles follow a normal distribution with a given standard deviation, enters a magnetic bottle where it is collimated to reduce its dispersion upon the exit of the thruster. In this second stage, we study the conditions for which the collimation produced, by the magnetic bottle, leads to the least thrust reduction. For the simulations, we assume electrons; However, the concepts apply to any charged particle species. The simulations show that the standard deviation of the pitch angle distribution has an important influence on the confinement of charged particles and on the thrust that can be generated when collimating the particle beam in a magnetic bottle.

The effect of sodium chloride on the charge state of soot particles in a laminar diffusion flame

This study investigates the effect of sodium chloride on the charge state of soot nanoparticles formed in a laminar diffusion flame by measuring the soot particle size distribution, average charge per particle, and charge fraction at various heights within the flame. The well-studied Santoro burner with methane as the fuel (at 0.35 L/min) and co-flow air (at 70 L/min) was used, which produced a stable laminar diffusion flame with flame height of 61 mm. Samples of soot nanoparticles were extracted via a 0.3 mm orifice in a 3-mm stainless steel tubular probe at various heights above the burner and were immediately diluted by a factor of a few thousand for aerosol measurement. The effect of sodium chloride on a methane flame was investigated by comparing the experimentally measured data for methane-only and methane-NaCl flames. The addition of NaCl particles to the laminar diffusion flame did not have a significant effect on the particles in the nucleation region of the flame. The majority of the incipient soot particles in both flames are uncharged, and their sizes are nearly the same, with diameters of approximately 5 nm or less. However, the size of soot particles differs by approximately 10 % to 25 % between methane-only and methane-NaCl flames in the coagulation-dominated region of the flame. The net charge on soot particles within the coagulation region of the methane-only flames is negative, while it is positive with NaCl addition. The fraction of charged particles and ion concentration decreases with NaCl addition within the coagulation region. The study indicates that the smaller particle size observed in methane-NaCl flames may be attributed to reduced coagulation via altered particle charge states. These factors could be the major contributor to the variations in soot formation between methane-only and methane-NaCl flames. Novelty and Significance StatementThis research addresses a notable knowledge gap concerning the influence of NaCl, a prevalent component of hydraulic fracturing fluids, on soot particle behaviour in flames. By explaining the impact of NaCl on soot formation and charge states, the findings contribute to a deeper understanding of combustion processes in environments influenced by hydraulic fracturing operations, thereby informing strategies for reducing emissions and improving environmental sustainability in energy production. Overall, this article represents a significant advancement in the field of combustion science, with implications for environmental stewardship in energy production.This study provides valuable insights into how the introduction of NaCl alters the electrostatic properties of soot particles. This investigation expands upon existing knowledge by shedding light on the intricate mechanisms underlying soot formation and evolution in the presence of NaCl, elucidating its potential implications for combustion processes involving fossil fuels and industrial flaring.

Temperature and inhomogeneous background affect plasmons in four-layer graphene structures

We employ the random-phase approximation to investigate the effects of temperature and the inhomogeneity of background dielectric on the collective excitations and respective broadening functions in 4-MLG structures. Computations present that the systems have four plasmon modes, corresponding to one in-phase and three out-of-phase oscillations of charged particles. We obtain that plasmon frequency and respective broadening functions behave as increasing functions of temperature with sufficiently large wave vectors. Dissimilarly, in small wave vector regions, the increase in temperature slightly decreases plasmon energy, but further increases in temperature increase this parameter. In addition, as the separation increases, both plasmon frequency and broadening functions significantly reduce, and the inhomogeneity of the dielectric background strongly decreases plasmon energy and its loss. We observe that both temperature and the environment's inhomogeneity should be considered in calculations.

Study of multiplicity dependence of heavy flavor production in pp collisions using rope hadronization mechanism

The multiplicity dependence of the production of the charm mesons in pp collisions at [Formula: see text][Formula: see text]TeV and 13[Formula: see text]TeV as measured by ALICE experiment has been investigated using Pythia 8 event generator by studying the effect of various processes at partonic level such as the effect of different modes of color reconnections and rope hadronization. The relative yields ([Formula: see text]) of D-mesons and [Formula: see text] as a function of relative charged particle multiplicity for various transverse momentum ([Formula: see text]) ranges as measured by the ALICE experiment are in reasonable agreement with the estimations of Pythia 8 model within the framework of microscopic processes. The relative yields of B mesons for various [Formula: see text] intervals ([Formula: see text][Formula: see text]GeV/c) have also been predicted in pp collisions at [Formula: see text][Formula: see text]TeV and [Formula: see text][Formula: see text]TeV.

Decoherence of a charged Brownian particle in a magnetic field: an analysis of the roles of coupling via position and momentum variables

Abstract The study of decoherence plays a key role in our understanding of the transition from the quantum to the classical world. Typically, one considers a system coupled to an external bath which forms a model for an open quantum system. While most of the studies pertain to a position coupling between the system and the environment, some involve a momentum coupling, giving rise to an anomalous diffusive model. Here we have gone beyond existing studies and analyzed the non-Markovian master equation, involving the quantum Langevin dynamics of a harmonically oscillating charged Brownian particle in the presence of a magnetic field and coupled to Ohmic (s = 1), sub-Ohmic (s < 1) and super-Ohmic (s > 1) heat baths via both position and momentum couplings. The presence of both position and momentum couplings leads to a stronger interaction with the environment, resulting in a faster loss of coherence compared to a situation where only position coupling is present. The rate of decoherence can be tuned by controlling the relative strengths of the position and momentum coupling parameters. In addition, the magnetic field results in the slowing down of the loss of information from the system, irrespective of the nature of coupling between the system and the bath. A faster decoherence rate is observed for higher values of the Ohmicity parameter ‘s’. Our results can be experimentally verified by designing a suitable ion trap setup.

Quantum-Annealing-Inspired Algorithms for Track Reconstruction at High-Energy Colliders

Charged particle reconstruction or track reconstruction is one of the most crucial components of pattern recognition in high-energy collider physics. It is known to entail enormous consumption of computing resources, especially when the particle multiplicity is high, which will be the conditions at future colliders, such as the High Luminosity Large Hadron Collider and Super Proton–Proton Collider. Track reconstruction can be formulated as a quadratic unconstrained binary optimization (QUBO) problem, for which various quantum algorithms have been investigated and evaluated with both a quantum simulator and hardware. Simulated bifurcation algorithms are a set of quantum-annealing-inspired algorithms, known to be serious competitors to other Ising machines. In this study, we show that simulated bifurcation algorithms can be employed to solve the particle tracking problem. The simulated bifurcation algorithms run on classical computers and are suitable for parallel processing and usage of graphical processing units, and they can handle significantly large amounts of data at high speed. These algorithms exhibit reconstruction efficiency and purity comparable to or sometimes improved over those of simulated annealing, but the running time can be reduced by as much as four orders of magnitude. These results suggest that QUBO models together with quantum-annealing-inspired algorithms are valuable for current and future particle tracking problems.

Past activity of Sgr A⋆ is unlikely to affect the local cosmic-ray spectrum up to the TeV regime

Context The presence of kiloparsec-sized bubble structures on both sides of the Galactic plane suggests active phases of Sgr A⋆, the central supermassive black hole of the Milky Way in the last 1–6 Myr. We investigated the contribution of such events to the cosmic-ray (CR) flux measured in the solar neighborhood with numerical simulations. Aims. We evaluate whether the population of high-energy charged particles emitted by the Galactic center could be sufficient to significantly impact the CR flux measured in the solar neighborhood. Methods. We present a set of 3D magnetohydrodynamical simulations following the anisotropic propagation of CRs in a Milky Way-like Galaxy. We followed independent populations of CRs through time. We followed CRs originating from two different source types, namely supernovae and the Galactic center. To assess the evolution of the CR flux spectrum properties, we split these populations into two independent energy groups of 100 GeV and 10 TeV. Results. We find that the anisotropic nature of CR diffusion dramatically affects the amount of CR energy received in the solar neighborhood. The typical timescale required to observe measurable changes in the CR spectrum slope is of the order 10 Myr, largely surpassing estimated ages of the Fermi bubbles in the active galactic nuclei (AGN) jet-driven scenario. Conclusions. We conclude that a CR outburst from the Galactic center in the last few million years is unlikely have produced any observable feature in the local CR spectrum in the TeV regime within times consistent with current estimates of the age of the Fermi bubbles.

TetraBall: A single-moderator neutron spectrometer for HL-LHC

This contribution presents a novel single-moderator neutron spectrometer, named “TetraBall”, developed at INFN and optimized for characterizing the neutron field in the CMS experimental cavern. The TetraBall condenses the functionality of several Bonner Spheres (BS) in a single moderator and it is equipped with 42 SiC radiation-hard detectors organized in a tetrahedral geometry designed to be insensitive to incident gammas and charged particles. Thanks to lead inserts, it can respond up to GeV energies. It works in single exposure mode, suitable for real-time monitoring. It is designed to be used as neutron monitor during the High-Luminosity LHC data taking.

Design of dark-colored acrylic coatings for increased LiDAR detection in autonomous vehicles

Light Detection and Ranging (LiDAR) is the major sensor for autonomous vehicles. It emits near-infrared (NIR) pulsed light at 905 nm and detects the reflected portion of this light from the surrounding objects. Location and surface determination of the surrounding objects is performed using the time-of-flight (the elapsed time from launch of a pulsed beam to detection of the reflected returned beam). Solvent borne acrylic paints gained wide currency for the exterior automotive coatings over the years and topcoats with conventional dark-colored pigment dispersions exhibit low reflectivity in the NIR region. The formulation of innovative topcoats with high reflectivity in this region is an urgent task for leading paint manufacturers. In this study, pigment dispersions to be incorporated in LiDAR-detectable solvent borne acrylic automotive topcoats were designed considering the surface charges of individual pigment particles for dispersant selection. Stability of designed dispersions was demonstrated and color matching studies were realized. Three dark colors encoded RAL 9011 (Graphite black), RAL 5017 (Traffic blue), and RAL 5015 (Sky blue) from the RAL 841-GL color chart were formulated as acrylic topcoats with NIR reflective pigments. Based on the surface properties of the dry films, such as gloss, haze and distinctness of image, a significant increase in LiDAR detection was achieved for each color. The results affirmed the potential use of the developed formulations as end-product paints for coating the exterior surfaces of autonomous vehicles.

Effect of Microwave Antenna Material and Diameter on the Ignition and Combustion Characteristics of ADN-Based Liquid Propellant Droplets

Microwave-assisted ignition is an emerging high-performance ignition method with promising future applications in aerospace. In this work, based on a rectangular waveguide resonant cavity test bed, the effects of two parameters (material and diameter) of the microwave antenna on the ignition and combustion characteristics of ADN-based liquid propellant droplets were investigated using experimental methods. A high-speed camera was used to record the droplet combustion process in the combustion chamber, the effect of the microwave antenna on the propellant combustion response was analyzed based on the emission spectroscopy method, and finally, the loss of the microwave antenna was evaluated using a scanning electron microscope. The experimental results show that the droplet has the lowest critical ignition power (179 W) when the material of the microwave antenna is tungsten, but the ignition delay time is higher than that of copper. A finer diameter of microwave antenna is more favorable for plasma generation. At a microwave power of 260 W, the ignition delay time of the droplet with a microwave antenna diameter of 0.3 mm is 100 ms lower than that of 0.8 mm, which is about 37.5%. In addition, this study points out the mechanism of microwave discharge in the droplet combustion process. The metallic microwave antenna not only collects the electrons escaping from the gas discharge, but also generates a large amount of metallic vapor, which provides charged particles to the plasma. This study provides the possibility for the application of microwave-assisted liquid fuel ignition.

The Ziré instrument onboard the NUSES space mission

The Ziré experiment is an instrument on board the NUSES (NeUtrino and Seismic Electromagnetic Signals) satellite dedicated to test new techniques for the study of low energy cosmic radiation, Sun–Earth environment, space weather and magnetosphere–ionosphere–lithosphere coupling (MILC). Ziré will consist of a fiber tracker, a stack of plastic scintillators, an array of LYSO crystals and an anticoincidence system. A dedicated Low Energy Module (LEM) will extend the sensitive energy range down to the MeV scale for charged particles. In this work, a general overview of the Ziré payload will be given, together with a focus on the design and the review of dedicated tests on the first prototype.

Pair correlations and freezing transitions in a two-dimensional system of tilted axially symmetric quadrupoles

We study the pair structure and the transition from the liquid to the solid state in a system of axially symmetric charged particles confined to a two-dimensional plane and characterised by only one non-zero component of the electric quadrupole moment, which we assume to be inclined with respect to the perpendicular to the confining plane. The particles interact via anisotropic repulsive quadrupole–quadrupole interactions. The pair correlation functions (PCF) were calculated by solving the hypernetted chain integral equation (HNC) theory in the range of the tilt angle 75.0 ∘ ≤ 90 ∘ − ϕ ≤ 90 ∘ . NVT Monte Carlo (MC) simulations were also performed to test the accuracy of the PCFs. We find that the PCFs calculated with the HNC theory agree well with those of the MC simulation at smaller tilt angles and show anomalous behaviour with respect to the in-plane angular variation. The PCFs obtained with the HNC theory were used in the Ramakrishnan-Yussouff (RY) density functional theory (DFT) to investigate the transition between liquid and solid freezing. It was found that the RY DFT stabilises the triangular solid only for tilt angles ≥ 80 ∘ . When the tilt angle is decreased compared to the normal orientation of the quadrupoles, the transition density increases.

Influence of Spectral Composition of Modulated Electromagnetic Wave on Radiation Intensity of Charged Particle

Influence of Spectral Composition of Modulated Electromagnetic Wave on Radiation Intensity of Charged Particle

New technologies for beam spectrometry, quality assurance, real-time monitoring and microdosimetry in BNCT

Boron neutron capture therapy (BNCT) is a next-generation radiotherapy that combines neutron beams with boron compounds that selectively accumulate in cancer cells. Because this therapy requires neutrons for irradiation, compact accelerator-based neutron source devices that can be installed in hospitals are being developed around the world. Clinical trials of several devices have been conducted in Japan, China, and South Korea. The most advanced device was approved by the Japanese regulatory authorities in 2020. As a result, BNCT with the device is being implemented as an insured therapy for recurrent head and neck cancer at two hospitals in Japan. Thus, the development of accelerator-based neutron generators is proceeding in the field of BNCT. However, much remains to be done to establish this therapy as a common cancer treatment and to make it available worldwide. Dosimetry methods in BNCT are one of the issues. In the treatment, the dose given to a patient by neutron irradiation has to be estimated accurately. However, it is difficult to measure neutrons accurately and in real time. Currently, the neutron dose delivered to patients during treatment is not measured. Instead, the current of the charged particles that irradiate the neutron target material is measured to indirectly evaluate the neutron fluence and dose. In addition, accurate dose estimation based on reactions with neutrons and various elements in a human body uses the Monte Carlo method, which is computationally time-consuming. To address these dosimetry issues, several neutron fluence and dose measurement methods are being developed. This review briefly describes the current dosimetry methods and then presents several methods under development that allow real-time neutron measurements applicable to BNCT.

Multiple-charging effects on the CCN activity and hygroscopicity of surrogate black carbon particles

Accurate measurements of cloud condensation nuclei (CCN) activity and hygroscopicity of black carbon (BC)-containing particles are particularly important because of the positive climate forcing from these particles. Such measurements are typically conducted on particles selected by a Differential Mobility Analyzer (DMA), which in addition to singly charged particles transmits multiply charged larger particles that have the same electrical mobility. These larger particles activate at lower supersaturations than the singly charged particles, biasing measurements and resulting in overestimation of CCN activity and hygroscopicity parameter (κ). Here, we measure the CCN activity and determine κ for different BC surrogates with electrical mobility diameters from 100 to 200 nm selected 1) only by electrical mobility with a DMA, and 2) by both electrical mobility and mass using a DMA and a Centrifugal Particle Mass Analyzer (CPMA), thus allowing selection of only singly charged particles. We demonstrate the use of the DMA-CPMA system in resolving biases caused by multiply charged particles, and we show that the effect of multiple charging on the CCN activity of the BC particles is strongly influenced by morphology dispersion, i.e., the variability due to the range of morphologies of particles that have the same electrical mobility and mass. Our findings show that electrical mobility-based methods alone are unlikely to lead to accurate results in measurements of CCN activation and hygroscopicity of BC particles, even for those with a more compact morphology.

Simultaneous removal of cyanobacteria and algal organic matter (AOM) by CaCO3 precipitation combined with Polyaluminum chloride (PACl) flocculation

Simultaneous removal of cyanobacteria and algal organic matter (AOM) is still a difficult task for drinking water treatment plants (DWTPs) during cyanobacteria blooms. CaCO3 precipitation, an environment-friendly drinking water treatment technique, has been recommended to removal cyanobacteria or AOM from drinking water. However, knowledge of simultaneous removal performance by CaCO3 precipitation is limited. Here, the simultaneous removal performance to cells and AOM of CaCO3 precipitation, combined with polyaluminum chloride (PACl) flocculation, was investigated, as well as the underlying mechanisms. The results showed that CaCO3 precipitation strategy significantly improved the simultaneous removal performance of PACl, with removal efficiency up to 98 % for cells and 48 % for AOM. CaCO3 precipitation exhibited reliable simultaneous removal effects at various initial cells densities and AOM concentrations. Scanning electron microscope (SEM), transmission electron microscope (TEM) and zeta potential results suggested that mutual flocculation between positively charged CaCO3 crystalline particles and negatively charged cells is the main responsible mechanism for cells removal. Despite that the adsorption of AOM on CaCO3 nuclei surface delays its precipitation, co-precipitation removal mechanism of AOM is realized during CaCO3 nucleation. Moreover, further AOM removal can be obtained by CaCO3 crystalline particles via chemisorption between organic molecules and the particles surface.

Revolutionizing treatment for topical fungal infections: evaluating penetration-enhancer-containing vesicles as a fluconazole delivery system: Ex-vivo and in-vivo dermal testing

Fungal infections pose a significant challenge in numerous developing nations and worldwide, necessitating urgent solutions. Oral administration of antifungal medications often leads to severe adverse reactions. Hence, employing topical delivery systems is preferred to ensure efficient dermal delivery of antifungal agents while minimizing side effects. Furthermore, the incorporation of penetration enhancers into nanocarriers loaded with antifungal agents has demonstrated enhanced efficacy in combating mycotic infections. Consequently, ultra-deformable penetration enhancer-containing vesicles (PEVs) were developed to explore this promising approach. In this study, Labrasol® and Transcutol® were used as penetration enhancers in formulating ultra-deformable PEVs containing the antifungal agent Fluconazole (FCZ). The PEVs underwent comprehensive characterization, including measurements of particle size (PS), charge, and entrapment efficiency (EE%). The results revealed that the size of tested PEVs ranged from 100 to 762 nm. All particles exhibited a negative charge, with a minimum zeta potential (ZP) of −38.26 mV, and an intermediate entrapment efficiency (EE%) that reached approximately 40%w/w. Ex-vivo studies demonstrated the ability of PEVs to deliver FCZ to the dermis while minimizing transdermal delivery. The selected formula was tested in-vivo using candidiasis-induced rat model and showed a superiority in its antifungal effect against Candida Albicans compared to the drug control. Stability studies were executed for the selected formula, and revealed good stability shown by the insignificant change in the PS, ZP& EE% over a six-month period.

Band structure for relativistic charged particles immersed in a structurally chiral electromagnetic field

In this paper, we determine the band structure of an electromagnetic space-time crystal. We construct a coordinate transformation in which the matrix elements of the Dirac equation are constant. Consequently, their corresponding band structure is recovered analytically. The band structure is fragmented into three different energy regions. In the center, there is a region prohibited for all particles (universal band gap), which is symmetrically enveloped by two energy regions of the same width. These regions allow the passage of particles with a specific spin (discriminatory band gaps). Furthermore, we demonstrate that, through the appropriate combination of the refractive index, the length of the electromagnetic wave, and the amplitude of the electric field, it is possible to shorten the bandwidth of the universal gap and replace it with a discriminatory band gap. In that sense, the proposed system constitutes an alternative procedure to observe the Schwinger mechanism experimentally.

Remote sensing of high energy charged particle current (HEC) for megavoltage therapeutic electron beams

Objective. We demonstrate detection of high energy particle current (HEC) for MeV therapeutic electron beams. Detection of HEC comprises of remote sensing or acquiring information about HEC inside radiation transport medium from a distance outside of the medium. Approach. HEC is self-propelled motion of charged particles through a radiation transport medium. Remote sensing of HEC is embodied in an experimental setup, which includes homogeneous and heterogeneous phantoms irradiated with 4–15 MeV electron beams and two large area parallel-plane electrodes extraneous to the phantoms providing two-parameter detection. We also introduce a new type of scanning method (depth-scan) for probing object properties along the beamline axis. Main Results. Deterministic radiation transport simulations and measurements agree, considering differences in simulation vs experimental geometry and experimental uncertainties. Significance. This method may be suitable for range detection of charged particle beams, or for probing of radiation opaque objects in non-destructive testing.