Carrier Particle Size Research Articles

Influence of carrier gas flow rate and particle size of AISI M2 in the laser-directed energy deposition process

ABSTRACT Additive manufacturing (AM) is a rapid prototyping technology that offers many advantages over conventional manufacturing processes. However, to make the most of the AM advantages, some requirements need to be met, such as the adjustment of process parameters and quality of the feedstock. This work assessed the influence of carrier gas flow rate and particle size of AISI M2 in the laser-directed energy deposition process (L-DED). Different carrier gas flow rates were tested for two powders with particle size of 53–150 µm (larger range) and 20–53 µm (lower range). The variation of carrier gas flow rate and particle size was assessed in single lines and layers. The results show that increasing the carrier gas flow rate provides better powder convergence in the region where there is interaction with the laser beam and faster particle velocity. The lower range tends to have greater efficiency in the deposition of single lines and layers. Regarding geometric characteristics, the aspect ratio did not show a well-defined trend as a function of the carrier gas flow rate and particle size, however, the layer height tends to be greater for the lower range, while the dilution tends to be greater for the larger range.

Bioavailability of Liposomal Vitamin C in Powder Form: A Randomized, Double-Blind, Cross-Over Trial

The purpose of this study was to evaluate the properties and pharmacokinetics of liposomal vitamin C in powder form obtained by a method devoid of organic solvents. The powder and liposome morphology were analyzed using scanning electron microscopy (SEM) and cryogenic transmission electron microscopy (cryo-TEM), respectively. Additionally, the carrier particle size, size distribution (STEP-Technology®; L.U.M. GmbH, Berlin, Germany), and zeta potential value were determined. The pharmacokinetic parameters of liposomal and non-liposomal vitamin C (AUC, Cmax, C10h, and C24h) were compared in a randomized, single-dose, double-blind, cross-over trial (ClinicalTrials.gov ID: NCT05843617) involving healthy adult volunteers (n = 10, 1000 mg dose). The process of spray drying used to transform liquid suspensions of the liposomes into powder form did not adversely affect the quality of the carrier particles obtained. Compared to non-encapsulated vitamin C, oral administration of the liposomal formulation resulted in significantly better absorption of ascorbic acid into the bloodstream, which equated to a higher bioavailability of the liposomal product (30% increase in AUC, p < 0.05). The duration of elevated vitamin C blood levels was also longer (C24h increase of 30%, p < 0.05). Although the results obtained are promising and suggest higher bioavailability for the liposomal form of vitamin C, the limited sample size necessitates further research with a larger cohort to confirm these findings.

Catalytic reduction of U(Ⅵ) to U(Ⅳ) using hydrogen as the sole reducing agent

Using hydrogen gas as a sole reducing agent to catalyze the reduction of hexavalent uranium to prepare tetravalent uranium can avoid the problem of pollutant poisoning catalysts caused by hydrazine reducing agents. However, research using only hydrogen as the sole reducing agent is very scarce. Herein, catalyst has been developed for catalytic hydrogen reduction to prepare uranium(Ⅳ) and a systematic study of the influence of process parameters such as catalyst carrier particle size, temperature, pressure, and acidity on the catalytic hydrogen reduction process for the preparation of uranium(Ⅳ) is presented. The effect of catalyst carrier particle size is particularly pronounced due to the differing rates of molecular diffusion. Fine particle-sized catalyst carriers exhibit faster catalytic reaction kinetics. Temperature exhibits an unusual phenomenon in its impact on the reaction process. As temperature increases, the reaction rate decreases, and an upper limit reaction temperature is observed. Furthermore, at excessively high reaction temperatures, an anomalous occurrence of uranium(Ⅳ) formation followed by disappearance was observed. Through an analysis of the reaction mechanism, the underlying reasons for this abnormal phenomenon are elucidated. Additionally, this paper also reveals that reaction rates increase with increasing reaction pressure and decrease with decreasing raw material acidity. Process parameters such as reaction temperature, pressure, and acidity exhibit coupled effects on the reaction process. Different reaction upper limit temperatures are observed under varying pressures and raw material acidities.

Mechanical properties and frost resistance of self-healing concrete based on expanded perlite with different particle sizes as microbial carrier

Microbial mineralization technology enables self-diagnosis and self-healing of concrete cracks, however, with the application of this technology, especially in cold regions, the involvement of water causes damage to concrete in freeze-thaw. Therefore, in this study, the mineralization properties of microorganisms at different low temperatures as well as the adsorption and charge characteristics of expanded perlite with different particle sizes as microbial carrier were investigated. Concrete specimens were prepared using self-healing agents with different particle sizes, and their mechanical and self-healing properties were comprehensively evaluated after freeze-thaw cycles. The results showed that the number of microbial colonies and urease activity decreased with the decline of freezing temperature, and the freeze-thaw cycling process exacerbated the further decrease of urease activity to 12.3% of the original activity. With the decrease of carrier particle size, the adsorption effect increased and the protective effect on microorganisms in alkaline environment was more significant. Concrete freeze-thaw tests showed that the best frost resistance was achieved with a self-healing dose of 0.6 mm-1.2 mm, with a mass loss and relative dynamic elastic modulus of 1.18% and 91.7% at 300 freeze-thaw cycles. Additionally, the self-healing dose in this particle size range showed the best repair performance with a maximum crack repair width of 1.063 mm and an average repair width of 0.512 mm, 0.479 mm, 0.443 mm, and 0.421 mm after 0, 100, 200, and 300 freeze-thaw cycles, respectively.

Numerical and Experimental Investigation for Application of CoNiCrAlY Coatings by HVAF

AbstractA relatively small change in oxide content and microstructure in MCrAlY coatings (M = Co, Ni) can affect the functionality of the coating for oxidation protection or as a bond coat. The objective of this study is to fabricate a CoNiCrAlY coating with low porosity and low oxide content. The high velocity air-fuel (HVAF) process, with its relatively low process temperature, is particularly suitable for the deposition of spray materials that are susceptible to oxidation or degradation at high temperature. A CFD simulation model of HVAF process is developed to determine the process parameters for fabricating CoNiCrAlY coating. The simulation results are validated by particle diagnostics, thereby establishing a comprehensive understanding of the underlying process. To assess the coating microstructure, XRD and EDS analyses as well as observation of cross sections of the coatings are conducted. The results highlight the influence of various factors, such as the variation of carrier gas and particle size distribution, on the quality of the coatings. Consequently, the utilization of simulation-based process parameter development is well supported by the coating fabrications, offering valuable insights into the processes prior to implementation.

Fabrication of marizomib-loaded zeolitic imidazolate framework-8@manganese dioxide for promising drug delivery system of glioma cancer cells

Marizomib is a novel, irreversible, brain-penetrant pan-proteasome inhibitor with encouraging findings in preclinical models and early-stage clinical trials for patients with newly diagnosed and recurrent glioblastoma. Marizomib (MRZ)-loaded zeolitic imidazolate framework-8 (ZIF-8) and manganese dioxide (MnO2) (termed as MRZ-ZIF-8 @MnO2) nanoparticles, a smart-functional therapeutic system, were prepared for the treatment of glioma cancer. Fourier transforms infrared (FTIR) and transmission electron microscope (TEM) were used to assess the structural and morphology properties of drug-loaded ZIF-8-NPs. The findings demonstrated this drug delivery carrier's narrow and particle size distribution. The anticancer drug MRZ released from the NPs was measured. The cell viability of glioma cancer cells (C6 and U87) treated with NPs was established using the cell counting kit-8. The in vitro proliferation of drug-loaded ZIF-8-NPs was substantially increased than that of free MRZ and drug-loaded ZIF-8-NPs treated cells. In addition, The C6 and U87 cell morphological staining studies, such as dual staining (acridine orange/ethidium bromide, AO/EB) and nuclear staining (4′,6-diamidino-2-phenylindole, DAPI), ascertain that the drug-loaded ZIF-8-NPs stimulates the apoptosis in glioma cancer cell lines. The results of morphological changes show that a high apoptosis level was found with drug-loaded ZIF-8-NPs. Reactive oxygen species (ROS) and mitochondrial membrane potential (MMP) validate the apoptotic mode of cancer cell death via the MMP pathway. These findings suggest that the as-fabricated MRZ-ZIF-8 @MnO2-NPs with the synergetic anticancer drug might be applied to treat glioma cancer.

Microstructural insight into inhalation powder blends through correlative multi-scale X-ray computed tomography

Dry powder inhalers (DPI) are important for topical drug delivery to the lungs, but characterising the pre-aerosolised powder microstructure is a key initial step in understanding the post-aerosolised blend performance. In this work, we characterise the pre-aerosolised 3D microstructure of an inhalation blend using correlative multi-scale X-ray Computed Tomography (XCT), identifying lactose and drug-rich phases at multiple length scales on the same sample. The drug-rich phase distribution across the sample is shown to be homogeneous on a bulk scale but heterogeneous on a particulate scale, with individual clusters containing different amounts of drug-rich phase, and different parts of a carrier particle coated with different amounts of drug-rich phase. Simple scalings of the drug-rich phase thickness with carrier particle size are used to derive the drug-proportion to carrier particle size relationship. This work opens new doors to micro-structural assessment of inhalation powders that could be invaluable for bioequivalence assessment of dry powder inhalers.

Lecithin Reverse Micelle System is Promising in Constructing Carrier Particles for Protein Drugs Encapsulated Pressurized Metered‐Dose Inhalers

AbstractProtein drugs contained within pressurized metered dose inhalers (pMDIs) show immense potential for fundamental research and industrial applications, owing to their high bioavailability, convenient administration, and cost‐effectiveness. To deliver protein drugs efficiently, researchers have reached a consensus on the use of carrier particles. However, the main obstacle impeding the commercial availability of pMDI carrier particles is their low stability. This instability is primarily attributed to particle aggregation caused by the Ostwald ripening phenomenon and chemical degradation by water sensitivity of protein drugs. This study proposes the utilization of lecithin, a carrier material possessing an amphiphilic structure, to overcome this bottleneck. By constructing lecithin‐based reverse micelle systems with protein drugs encapsulated within the high‐polarity microdomain, this work anticipates an improvement in the stability of carrier particles within pMDIs. Specifically, the formation of crystalline phases in the reverse micelle systems can control carrier particle size through crystalline self‐limiting effect, preventing particle aggregation. Additionally, the low‐polarity microdomain of the carrier serves as a hydrophobic barrier, shielding protein drugs from water and preventing chemical degradation. Consequently, this work believes that the lecithin‐based reverse micelle system holds significant potential in providing new theoretical insights and experimental support for the advancement of pMDIs containing protein drugs.

The match between adhesive mixture powder formulations for inhalation and the inhaler device

The device or the formulation? Which one governs drug dispersibility from the inhaler? To address this question, three budesonide-containing reservoir DPIs: Novopulmon Novolizer®, Giona Easyhaler® and DuoResp Spiromax®, were analyzed using the Next Generation Impactor, NGI. Thereafter, the devices were carefully opened, emptied, and formulations were switched between devices. Finally, three ‘prototype’ formulations with carriers of different particle size were produced and tested in the Novolizer and Easyhaler devices.Among the DPI products, the two devices which have a flow path with a cyclone-type geometry, i.e., the Novolizer and the Spiromax, yielded a fine particle fraction, FPF, above 40%. The Easyhaler, which has a straight mouthpiece outlet, produced an FPF of 18%. When the Novopulmon and the DuoResp formulations were assayed in the Easyhaler device, poor fine particle fractions were obtained. To the contrary, the Giona formulation produced a high FPF when tested in the Novolizer device. The results clearly show that the device is the dominating factor to dispersibility for the investigated products. Along the same lines, all three ‘prototype’ formulations produced high fine particle fractions in the Novolizer device, with the formulation with the largest carrier giving the best performance. Tested in the Easyhaler device, the prototype formulations produced low fine particle fractions, but interestingly, the formulation with the smallest carrier particle size yielded the highest FPF. It can be concluded that there is a link between inhaler design and the effect of carrier particle size, where larger carriers provide better dispersion in cyclone-type devices while smaller carriers seem to be more beneficial for inhalers which has a straight flow path for the powder formulation.

Impact of particle size of cell carrier on caproate fermentation in a cell immobilized system: Focusing on the improvement of caproate production in batch and continuous operation modes

Wheat straw is a superior matrix for cell immobilization, yet the influence of its particle size on caproate fermentation is unclear. In this study, the influence of particle size of wheat straw on caproate production, biofilm formation and mass transfer was investigated in the cell immobilized system. Results showed that the maximum caproate production achieved 14.4 g/L in batch tests and the optimum particle size of wheat straw was in the range of 5–10 mm. Analysis on the biomass, extracellular polymeric substances (EPS), Fourier transform infrared spectroscopy (FTIR), Thermogravimetry (TG) and zeta potential revealed that the biofilm of Clostridium kluyveri was formed on the cell carrier, which explained the high caproate production at the optimum condition. The highest mass transfer coefficient of 0.738 m/s was observed with the optimum particle size. Bubble formation on the cell carrier promoted the floating of cell carrier, which benefited the mass transfer from fermentation broth to immobilized cells as well as biofilm formation. Taking the optimized wheat straw as cell carrier in the continuous operation mode, the highest mean caproate production reached 19.6 g/L, and the mean caproate production achieved 18.3 g/L when the food waste-based ethanol and acetate were used as substrates. The high caproate production was ascribed to the formation of thick biofilm on the cell carrier which kept its chemical structure stable during the long term fermentation.

Impact of Particle Size Polydispersity on Chemical Looping Combustion of Biomass under a Continuous Injection Mode

Particle size polydispersity considerably influences the chemical looping combustion (CLC) of solid fuels. In the present work, a three-dimensional multiphase particle-in-cell (MP-PIC) method was established and applied to study the full-loop CLC of biomass under a continuous injection mode. After model validation, the gas–solid flow characteristics, solid circulation rate (SCR), particle mixing in a fuel reactor (FR), and biomass leakage at different oxygen carrier (OC) particle size distribution (PSD) widths and biomass densities were systematically explored. The results showed that OC particles significantly stratified within the FR and both loop seals. Moreover, the fluctuation amplitude of the SCR decreased as the OC PSD width increased. Small biomass particles were more likely to leak. The number fraction of total leaked biomass particles first decreased and then increased as the OC PSD width increased. In the FR, small OC particles were primarily distributed in the upper part of the bed, and large particles were mainly distributed in the lower part. In addition, within the test range, the magnitude of the density difference between biomass and OC particles positively correlated with the likelihood of biomass leaking. These observations are all beneficial for the design and optimization of the CLC process of biomass.

Design of an industrial chemical looping gasification system

A design methodology for an industrial Chemical Looping Gasification (CLG) unit is proposed, including the reactor system, oxygen carrier, solid fuel, key parameters, mass and energy balance, reactor dimension, and emissions. To determine a reactor system for CLG, the first design step is to choose between four types of systems and their applicability. The selection of a circulating material and a particle size of the oxygen carrier and the solid fuel is discussed. Determination of the key operating parameters comprises oxygen-to-fuel ratio, steam-to-fuel ratio, charging/discharging of the oxygen carrier and the conversion difference between an air reactor and a fuel reactor, their temperatures, velocities in each reactor, and cyclone efficiency. As design basis, the mass and energy balance of the system is computed based on the distribution of syngas composition and oxygen transportation over the system. It is not critical to obtain an adequate circulation for a CLG unit. But to satisfy the heat balance, oxygen transport and reasonable efficiency of syngas production at the same time makes CLG technology challenging. More work is needed for the introduced design items in the case of commercial-scale units.

Lack of CB1 receptor reduces preterm birth rate in an LPS-induced murine model

Dry powder inhalers (DPIs) are known to be sensitive to humidity. Erroneous storage of these products by patients in high humidity environments, could present a potential risk. Therefore, an in-vitro-in-silico approach was utilized to assess the risk that patient erroneous storage might pose. For this two commercial DPIs containing lactose and budesonide (Easyhaler® and Novolizer®) were used. These were evaluated in respect to their physical solid-state and micrometric properties as well as their in-vitro aerodynamic performance. Testing was carried out at time 0, 14 and 28 days after storage at 60% RH and > 90% RH. Using in-silico modeling the potential impact of powder sensitivity to humidity on the biopharmaceutical performance of budesonide was evaluated. Results revealed that the physical and aerodynamic properties of the powders having a smaller carrier particle size and a higher amount of excipient fines were more notably affected. Use of in-vitro results as inputs for in-silico pharmacokinetic modeling showed that some changes in powder properties can have a potential impact on the pulmonary availability of budesonide. So, it appears that it is important to consider the impact that different product characteristics might have on the physical stability of powders against moisture and their subsequent biopharmaceutical performance.

Quantifying Uncertainty in the Residence Time of the Drug and Carrier Particles in a Dry Powder Inhaler

Abstract Dry powder inhalers (DPI), used as a means for pulmonary drug delivery, typically contain a combination of active pharmaceutical ingredients (API) and significantly larger carrier particles. The microsized drug particles—which have a strong propensity to aggregate and poor aerosolization performance—are mixed with significantly large carrier particles that cannot penetrate the mouth-throat region to deagglomerate and entrain the smaller API particles in the inhaled airflow. Therefore, a DPI's performance depends on the carrier-API combination particles' entrainment and the time and thoroughness of the individual API particles' deagglomeration from the carrier particles. Since DPI particle transport is significantly affected by particle-particle interactions, particle sizes and shapes present significant challenges to computational fluid dynamics (CFD) modelers to model regional lung deposition from a DPI. We employed the Particle-In-Cell method for studying the transport/deposition and the agglomeration and deagglomeration for DPI carrier and API particles in the present work. The proposed development will leverage CFD-PIC and sensitivity analysis capabilities from the Department of Energy laboratories: Multiphase Flow Interface Flow Exchange and Dakota UQ software. A data-driven framework is used to obtain the reliable low order statics of the particle's residence time in the inhaler. The framework is further used to study the effect of drug particle density, carrier particle density and size, fluidizing agent density and velocity, and some numerical parameters on the particles' residence time in the inhaler.

Effect of carrier particle size on enrichment and shift in nitrifier community behaviors for treating increased strength wastewater.

In activated sludge systems, adding carriers can improve nitrifier enrichment. Different attachment area induced by different particle sizes of carriers may result in different nitrifier community. This research investigated the effect of different particle sizes of coal ash on nitrifier enrichment treating increased strength wastewater. Results indicated efficient nitrifying coal ash was obtained with smaller coal ash. The ammonia removal rates reached over 98%, which outclassed that in negative control (63.28%), and no nitrite accumulated in these systems under high nitrogen concentration of 1123.35mgN/L. The high-throughput sequencing assays indicated carriers changed the microbial community structure significantly, thus facilitated the nitrification capacity. Increase abundance of nitrifier has a negative correlation with particle size of carriers. Nitrosomonas became the biggest beneficiary, which maximum composed 50.29% in fillers system and only 13.69% in negative control, whereas the number of Nitrobacter (less than 3.04%) became much lower than ammonia-oxidizing bacteria (AOB). However, the shift of microbial structures, large number of Dokdonella for instance, may guarantee the complete nitrification in systems with smaller carriers. Batch experiments showed a high dissolved oxygen (DO) concentration (4mg/L) and slightly alkaline condition (pH 8.0) had a positive effect on nitrifying coal ash. PRACTITIONER POINTS: The increase size of nitrifier has a negative correlation with particle size of coal ash. The smaller coal ash reduces the adverse effect of high nitrogen on nitrification. The ammonia removal rate reached 99.82% with influent of 1123.35mg /L in the smallest carriers system.

Discrete Phase Modeling of the Powder Flow Dynamics and the Catchment Efficiency in Laser Directed Energy Deposition With Inclined Coaxial Nozzles

Abstract Laser directed energy deposition (DED) is one of the most promising additive manufacturing processes for restoring high-value components. The damaged components can have complex free-form shapes, which necessitate depositions with an inclined nozzle, where the gravity can adversely affect the powder flow dynamics and the powder catchment efficiency (PCE). PCE is defined as the fraction of the total mass flowrate entering the melt pool, and a low PCE can render the process inviable. In this paper, the effect of nozzle inclination on the powder flow dynamics and resulting PCEs have been studied. It was found that the powder flow dynamics is altered significantly in an inclined nozzle and results in an asymmetric and skewed powder jet. The PCE deteriorates rapidly with an increase in the nozzle inclination due to the progressive defocusing and falls below 20% at 75 deg. A discrete phase model has been developed to understand the powder flow dynamics at different inclinations and process conditions. The mass flow distribution asymmetries on the focal plane at various nozzle inclinations have been analyzed via the model. The model can predict PCEs at different nozzle inclinations with reasonable accuracy ranging from 5.4% at 0-deg inclination to 29.2% at 45-deg inclination. The carrier gas flow, particle size, and laser diameter affect the PCE significantly and can be used to counter the enhanced powder loss at large nozzle inclinations. Process maps have been developed to identify the favorable, acceptable, and low PCE regions to select optimal DED parameters.

Effect of carrier fluid and particle size distribution on the rheology of shear thickening suspensions

We present a systematic rheological study on the fumed silica suspensions to understand the effect of particle and fluid parameters on the critical shear rate and shear thickening ratio. It was observed that removal of air bubbles and water contamination is crucial to prepare good shear thickening fluids. A careful sample preparation method was adopted to properly disperse the fumed silica particles in polyethylene glycol solution, and we achieved discontinuous shear thickening at low particle concentration. It was observed that the critical shear rate in shear thickening suspension is strongly influenced by both carrier fluid and particle concentration. However, the shear thickening ratio is mainly influenced by the particle parameters and the frictional forces between the particles. Increasing the amount of smaller particles in the suspension significantly decreases the maximum viscosity and shifts the onset of shear thickening to higher values of critical shear rates with much smaller shear thickening ratio. Further, a possible mechanism has been proposed based on the influence of carrier fluid and particle size distribution to explain the rheological behaviour of shear thickening suspension. Our study supports the theory of particle-particle frictional contacts as the main reason for the discontinuous shear thickening.

Influence of clay-based additive on sedimentation stability of magnetorheological fluid

Sedimentation stability is one of the most important features of magnetorheological (MR) fluids. Clay-based additives are known for improving the stability of the MR fluids. This article describes the dependency of the clay-based additive concentration on the sedimentation stability and the rheological properties of MR fluids in non activated state (without magnetic field). The sedimentation was measured for two different base oil viscosities, two different carbonyl iron particle sizes, and additive concentration between 2 and 6 wt%. The measurements showed that the sedimentation rate exponentially decreases with the additive concentration, while the yield stress is rising. The measurements of rheological properties also showed the dependency of rheological properties of MR fluid with a clay-based additive on loading history. The influence of carrier fluid viscosity or particle size has a minor effect on the sedimentation in comparison with the clay-based additive. The addition of 6 wt% slows down the sedimentation by more than 3000 times compared to MR fluid without additives. The MR fluid with 4.85% of clay-based additive achieves slightly better sedimentation stability than commercial MR fluid LORD MRF122.

Low chlorine oil production through fast pyrolysis of mixed plastics combined with hydrothermal dechlorination pretreatment

Fast pyrolysis of the mixed plastics (PE: PP: PS: PVC = 0.5: 0.3: 0.15: 0.05) with and without hydrothermal dechlorination pretreatment were investigated in a fixed bed reactor to determine the effects of pyrolysis parameters (temperature, carrier gas flow rate and particle size) on the distribution and the quality of the products. The results showed that high pyrolysis temperature, high carrier gas flow rate and small particle size promoted the migration of organic chlorine in condensable products to inorganic chlorine in gas products. And the optimal conditions for fast pyrolysis of mixed plastics to produce oil were the pyrolysis temperature of 500 °C, carrier gas flow rate of 40 ml/min and particle size of 0.1–0.15 mm with the maximum oil yield of 67.88 wt%. Hydrothermal pretreatment of mixed plastics has shown an excellent dechlorination efficiency of 99.9 %. Furthermore, the total yield of oil and wax was increased by 7.06 wt%, meanwhile the content of C5-C9 components in the pyrolysis oil showed an upward trend when compared with fast pyrolysis without pretreatment. Besides, the concentration of methane achieved 50.68 % due to the possible weakening effect of hydrothermal pretreatment on CC bond energy of β-position.

Hydrogen-rich syngas production by chemical looping reforming on crude wood vinegar using Ni-modified HY zeolite oxygen carrier

The crude wood vinegar contained a large amount of water and a small amount of complex organic compounds, which was difficult to industrialize practically. An efficient oxygen carrier was prepared by Ni-modified HY zeolite (Ni/HY) to produce hydrogen-rich syngas by chemical looping reforming (CLR) on crude wood vinegar. The yield of gas, conversion efficiency, H2/CO, oxygen carrier structure and carbon deposition were investigated to obtain the optimal preparation of oxygen carrier and the optimal CLR performance. The results showed that HY zeolite was the most suitable carrier for CLR among five different molecular sieves. Compared with HY zeolites modified by different metallic oxides, Ni/HY had the highest H2 yield of 64.68%, gasification efficiency of 85.29% and structural characteristics. Further, water volume had a great impact on the CLR performance. The optimal water volume was + 15% with H2 yield of 68.4%, carbon conversion efficiency of 37.58% and gasification efficiency of 92.38%. Furthermore, the particle size of oxygen carrier increased with the increase of Ni loading. The best performance with gasification efficiency of 96.17% and carbon conversion efficiency of 39.41% could be obtained when the Ni loading was 20%.Moreover, the CO yield, gasification efficiency and carbon conversion efficiency gradually increased with temperature increasing. After CLR for the long-term reaction time, 900 °C was the best reaction temperature to achieve gasification efficiency of 107.29% and the lowest carbon deposition of 3.71%.