Plastic products have become an integral part of our life. A widespread usage, high stability, uncontrolled disposal and slow degradation of plastics in the environment led to the generation and accumulation of nanoparticles of polymers (NPs) in the marine environment. However, little is known about the aggregation, consumption and distribution of NPs from common polymers such as polyvinyl chloride (NP-PVC) and polymethyl methacrylate (NP-PMMA) inside marine animal physiologies. In the current study, two types of polymers (PVC and PMMA) × four exposure concentrations (1, 5, 15 and 25 mg/L) × four times (4, 8, 12 and 24 h) exposure studies were conducted to understand the consumption and distribution of luminescent NP-PVC (98.6 ± 17.6 nm) and NP-PMMA (111.9 ± 37.1 nm) in R. philippinarum. Under laboratory conditions, NP-PVC showed a higher aggregation rate than NP-PMMA in seawater within a period of 24 h. Aggregations of NPs increased with an increase in initial NP concentrations, leading to significant settling of nanoparticles within 24 h exposure. Such aggregation and settling of particles enhanced the consumption of NPs by benthic filter-feeding R. philippinarum at all exposure concentrations during 4 h exposure. More interestingly, NP-PVC and NP-PMMA were observed in large amounts in both liver and gills (22.6 % - 29.1 %) of the clams. Furthermore, NP-PVC was detected in most organs of R. philippinarum as compared to NP-PMMA. This study demonstrates that different polymers distribute and accumulate differently in the same biological model under laboratory exposure conditions based on their chemical nature.