Charged Particles Research Articles

Coherence of Multidimensional Pair Production Discharges in Polar Caps of Pulsars

We report on the first self-consistent multidimensional particle-in-cell numerical simulations of nonhomogeneous pair discharges in polar caps of rotation-powered pulsars. By introducing strong inhomogeneities in the initial plasma distribution in our simulations, we analyze the degree of self-consistently emerging coherence of discharges across magnetic field lines. In 2D, we study discharge evolution for a wide range of physical parameters and boundary conditions corresponding to both the absent and free escape of charged particles from the surface of a neutron star. We also present the results of the first 3D simulations of discharges in a polar cap with a distribution of the global magnetospheric current appropriate for a pulsar with 60° inclination angle. For all parameters, we find the coherence scale of pair discharges across magnetic field lines to be of the order of the gap height. We also demonstrate that the popular “spark” model of pair discharges is incompatible with the universally adopted force-free magnetosphere model: intermittent discharges fill the entire zone of the polar cap that allows pair cascades, leaving no space for discharge-free regions. Our findings disprove the key assumption of the spark model about the existence of isolated distinct discharge columns.

Synergistic flocculation performance and underlying mechanisms of a novel bioflocculant flocan with coagulant iron salt

Flocculation is an integral part of wastewater treatment units and various flocculants have been employed to strengthen the flocs formation and produce clean water. Natural polysaccharides have been employed as eco-friendly bioflocculants for the treatment of turbid water. In the study, flocan is a named exopolysaccharide (EPS) isolated from a coastal mudflat with a high yield of 8.3g/L. Flocan consisted of glucose, mannose, galactose, and glucuronic acid in a molar ratio of 2:3:1:1, along with pyruvate modifications. As the bioflocculant agent, flocan exhibited more than 85% removal efficiency in kaolin suspension in terms of a concentration of 10mg/L at pH 3. The addition of iron salts with flocan showed high flocculation efficiency in acidic kaolin suspension (99.37%) and acidic coal wastewater (99.44%). The carboxyl/hydroxyl groups and branched structure of flocan provided ionic interactions and promoted higher bridging between bioflocculants and negatively charged particles. Coagulants FeCl3 enhanced the flocculating activity via neutralizing and stabilizing the residual negative charge of functional groups. Treatment with EDTA decreased the ionic interactions and reversed the flocculation significantly. Compared with the current bioflocculants, the superior production, low dosage, and excellent flocculating activity implied that flocan showed great potential in acidic wastewater treatment industrially. The coagulants/bioflocculants combination appears to be a promising and sustainable technology for wastewater flocculation.

Rydberg excitons in cuprous oxide: A two-particle system with classical chaos.

When an electron in a semiconductor gets excited to the conduction band, the missing electron can be viewed as a positively charged particle, the hole. Due to the Coulomb interaction, electrons and holes can form a hydrogen-like bound state called the exciton. For cuprous oxide, a Rydberg series up to high principle quantum numbers has been observed by Kazimierczuk et al. [Nature 514, 343 (2014)] with the extension of excitons up to the μm-range. In this region, the correspondence principle should hold and quantum mechanics turn into classical dynamics. Due to the complex valence band structure of Cu2O, classical dynamics deviates from a purely hydrogen-like behavior. The uppermost valence band in cuprous oxide splits into various bands resulting in yellow and green exciton series. Since the system exhibits no spherical symmetry, the angular momentum is not conserved. Thus, the classical dynamics becomes non-integrable, resulting in the possibility of chaotic motion. Here, we investigate the classical dynamics of the yellow and green exciton series in cuprous oxide for two-dimensional orbits in the symmetry planes as well as fully three-dimensional orbits. Our analysis reveals substantial differences between the dynamics of the yellow and green exciton series. While it is mostly regular for the yellow series, large regions in phase space with classical chaos do exist for the green exciton series.

On the effect of the maximal proper acceleration in the inertia

The effect of a hypothetical maximal proper acceleration on the mass of a charged particle is investigated in the context of particle accelerators. In particular, it is shown that maximal proper acceleration implies an increase in the kinetic energy of the particle being accelerated with respect to the relativistic energy. Such an increase in kinetic energy leads to a reduction of the luminosity of the bunches with respect to the expected luminosity in the relativistic models of the bunches. This relative loss in luminosity is of the order 10 −3 to 10 −5 for the Large Hadron Collider (LHC) bunches and can be of order up to 10 −3 for certain laser-plasma accelerator facilities. Although the effect is small, it increases with the square of the bunch population.

Development of a charged particle-[formula omitted] coincidence system for nuclear structure and reaction studies at TIFR

A new detector system for measurements of charged particles and γ-rays in coincidence has been developed at TIFR Mumbai, by coupling an annular double-sided segmented Si detector with an array of Compton-suppressed clover HPGe detectors. Digital data acquisition system has been configured for the setup, which has been calibrated and tested using the 229Th radioactive source that emits α-particles along with γ-rays. The functionality and performance of the coincidence apparatus for Doppler correction of γ-transitions emitted during the in-flight de-excitation of the projectile and the target in the 30Si + 197Au Coulomb excitation experiment have been demonstrated.

Deflection of charged signals in a dipole magnetic field in Kerr background

This paper investigates charged particle deflection in a Kerr spacetime background with a dipole magnetic field, focusing on the equatorial plane and employing the weak field approximation. We employ the Jacobi–Randers metric to unify the treatment of the gravitational and electromagnetic effects on charged particles. Furthermore, we utilize the Gauss–Bonnet theorem to calculate the deflection angle through curvature integrals. The difference between the prograde and retrograde deflection angles is linked to the non-reversibility of metrics and geodesics in Finsler geometry, revealing that this difference can be considered a Finslerian effect. We analyze the impact of both gravitomagnetic field and dipole magnetic field on particle motion and deflection using the Jacobi–Randers magnetic field. The model considered in this paper exhibits interesting features in the second-order approximation of (M/b), i.e., the ratio between the spacetime mass and impact parameters. When qμ=2MaE\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$q\\mu =2MaE$$\\end{document}, where q,E\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$q,\\,E$$\\end{document} are the charge and asymptotic energy of the charged particle and μ,a\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$\\mu ,\\,a$$\\end{document} are the dipole magnetic moment and spacetime spin, the Jacobi–Randers metric possesses reversible geodesics, leading to equal prograde and retrograde deflection angles. In this case, the gravitomagnetic field and dipole magnetic field cancel each other out, distinguishing it from scenarios involving only the gravitomagnetic field or the dipole magnetic field. We also explore the magnetic field’s impact on gravitational lensing of charged particles.

Observation of Enhanced Long-Range Elliptic Anisotropies Inside High-Multiplicity Jets in pp Collisions at sqrt[s]=13 TeV.

A search for collective effects inside jets produced in proton-proton collisions is performed via correlation measurements of charged particles using the CMS detector at the CERN LHC. The analysis uses data collected at a center-of-mass energy of sqrt[s]=13 TeV, corresponding to an integrated luminosity of 138 fb^{-1}. Jets are reconstructed with the anti-k_{T} algorithm with a distance parameter of 0.8 and are required to have transverse momentum greater than 550GeV and pseudorapidity |η^{jet}|<1.6. Two-particle correlations among the charged particles within the jets are studied as functions of the particles' azimuthal angle and pseudorapidity separations (Δϕ^{*} and Δη^{*}) in a jet coordinate basis, where particles' η^{*}, ϕ^{*} are defined relative to the direction of the jet. The correlation functions are studied in classes of in-jet charged-particle multiplicity up to N_{ch}^{j}≈100. Fourier harmonics are extracted from long-range azimuthal correlation functions to characterize azimuthal anisotropy for |Δη^{*}|>2. For low-N_{ch}^{j} jets, the long-range elliptic anisotropic harmonic, v_{2}^{*}, is observed to decrease with N_{ch}^{j}. This trend is well described by MonteCarlo event generators. However, a rising trend for v_{2}^{*} emerges at N_{ch}^{j}≳80, hinting at a possible onset of collective behavior, which is not reproduced by the models tested. This observation yields new insights into the dynamics of jet evolution in the vacuum.

Development observed in the field of the Antarctic bivalve mollusc Aequiyoldia eightsii at Signy Island, South Orkney Islands

ABSTRACT The embryonic development of marine ectotherms has been shown to be strongly temperature dependent across the world's oceans. However, at the coldest sites, in the polar regions, development is even slower than would be predicted on the basis of the temperature dependence of development in warmer waters, and this is thought to be a consequence of changes in physical characteristics of cytoplasm near 0 °C—such as viscosity and osmolyte packing that slow protein folding and increase the likelihood of interference by charged particles, and their effect on protein synthesis. The overwhelming majority of studies of rates of embryonic development have been laboratory-based, with animals either collected directly from the sea and spawned in the laboratory or held first in the laboratory and preconditioned to set environments before spawning. Few studies have assessed development from regularly collected samples and assessed field development, especially from polar latitudes. Here we present data for the Antarctic bivalve mollusc Aequiyoldia eightsii, tracking its development from spawning on 25/26 May to hatching of pelagic veligers on 12 June and the disappearance of pediveliger larvae from the water column at the end of September or early October, 108–114 days later. Larval dry mass was constant at 16.7 µg (SE = 0.19) across the pelagic phase, except for the initial few days after hatching when it was 9.55 µg (SE = 0.60). The difference was likely the calcification of the larval shell. The development time to trochophore was 189 h, and this was in line with previous studies showing larval development at temperatures around 0 °C is around 4–22 times slower than would be predicted from the general effect of temperature on development rates.

Research progress on long lifetime MCP-PMT for the DTOF detector in STCF

The Super Tau Charm Facility (STCF) is a state-of-the-art electron-positron collider operating in the center-of-mass energy range of 2–7[Formula: see text]GeV and achieving a peak luminosity of more than [Formula: see text][Formula: see text]cm−2s−1, which is pivotal for advancing particle physics research. The DIRC-like time-of-flight (DTOF) detector is one of the crucial components of the STCF, designed to identify high-momentum charged particles with high precision. A significant element of the DTOF is the microchannel plate photomultiplier tube (MCP-PMT), known for its exceptional time resolution in the detection of Cherenkov light. With the STCF expected to operate for over a decade, stringent requirements are imposed on the MCP-PMT, requiring an integrated anode charge (IAC) in excess of 10[Formula: see text]C/cm2. In this paper, the lifetime of the single anode MCP-PMT prototypes is investigated and a multi-anode MCP-PMT design is presented. The results show that the lifetime of the single anode MCP-PMT is greater than 11[Formula: see text]C/cm2 when a 6 nm-thick ALD layer is deposited on the inner surface of the MCP and an electron scrubbing dosage of 0.75[Formula: see text][Formula: see text]A[Formula: see text][Formula: see text][Formula: see text]h/cm2 is applied to the MCP. The lifetime is expected to be further improved by increasing the electron scrubbing dosage and optimizing the ALD layer. The studies on the single anode MCP-PMTs will be applied to the development of the long-life multi-anode MCP-PMT.

Correlation functions of weakly inhomogeneous plasma

This article focuses on the kinetic theory of inhomogeneous plasma and explores the interaction between a high-frequency electric field and weakly inhomogeneous plasma. Particularly, it examines the impact of an external variable field on the kinetic and high-frequency properties of the plasma, including kinetic equations, correlation functions, and distribution functions of charged particles. The study derives expressions for the pair (two-particle) correlation function and the corresponding distribution function, taking into ac- count the spatial inhomogeneity of the plasma and electric field, as well as the collisions between charged particles. The results were obtained using the kinetic equation for the spatial-temporal spectral density of fluctuations and the method of successive approximations (separation of slow motions and fast oscillations). The field amplitude is considered a slowly varying function of time and coordinates. The calculations neglect the contribution of the magnetic component of the electromagnetic field, which is applicable to longitudinal electric fields. The results obtained in this article are primarily of theoretical interest, they reveal the picture of the interaction of a weakly inhomogeneous plasma with a high-frequency electric field and can be used in the construction of a kinetic theory of an inhomogeneous plasma located in high-frequency electromagnetic fields. Note that for charged particles of the same sign, the correlation function is negative, and for particles of different signs it is positive. In addition, the correlation function is exponentially small when the distance between the particles is greater than the Debye radius. In all calculations, the contribution of the magnetic component of the electromagnetic field is neglected, which is quite true for the longitudinal electric field.

Vetoing charged particles for neutrino detection at the LHC

The SND@LHC detector is an experiment to study neutrinos produced at the Large Hadron Collider (LHC). The detector is designed to distinguish the three neutrino flavors by featuring an 800 kg tungsten target combined with emulsions and electronic trackers, followed by a calorimeter and a scintillating muon system. The acceptance of SND@LHC also provides a unique opportunity to study heavy-flavor production in regions inaccessible to other LHC experiments such as ATLAS, CMS, and LHCb. To mitigate the veto inefficiency observed in 2022, the SND@LHC Collaboration has implemented design modifications. These include lowering the veto system and adding a third layer of scintillating bars. Tests of the new Veto 3 module demonstrated high uniform efficiency, leading to its successful installation and integration.

Charge sign dependence of recurrent Forbush decreases in 2016–2017

Context. This study investigates the periodicities of galactic cosmic ray flux attributed to corotating interaction regions (CIRs) using Alpha Magnetic Spectrometer (AMS-02) data from late 2016 to early 2017. Aims. We determine the rigidity dependence of recurrent Forbush decrease (RFD) amplitudes induced by CIRs for different particles with a focus on charge sign. Methods. We carried out a frequency analysis using a Lomb-Scargle algorithm and superposed epoch analysis for all particles. For protons and helium, we compared the results with a single Forbush decrease (FD) analysis. Results. Our results reveal that the rigidity dependence of proton amplitudes attributed to the northern coronal hole is in qualitative agreement with previous findings. In contrast, the amplitudes attributed to the southern coronal hole show no rigidity dependence. Furthermore, the amplitude of the helium modulation exceeds that of protons, in line with the observation for long-term modulation. For positrons, statistical limitations stand in the way of any definitive conclusions. In comparison to the positively charged particles, the modulation behavior of electrons reveals a different pattern.

Acrylic Acid Modified Poly-ethylene Glycol Microparticles for Affinity-Based release of Insulin-Like Growth Factor-1 in Neural Applications.

Sustained release of bioactive molecules via affinity-based interactions presents a promising approach for controlled delivery of growth factors. Insulin-like growth factor-1 (IGF-1) has gained increased attention due to its ability to promote axonal growth in the central nervous system. In this work, we aimed to evaluate the effect of IGF-1 delivery from polyethylene-glycol diacrylate (PEG-DA) microparticles using affinity-based sustained release on neurons. We developed PEG-DA-based microparticles with varying levels of acrylic acid (AA) as a comonomer to tune their overall charge. The particles were synthesized via precipitation polymerization under UV light, yielding microparticles (MPs) with a relatively low polydispersity index. IGF-1 was incubated with the PEG-DA particles overnight, and formulations with a higher AA content resulted in higher loading efficiency and slower release rates over 4 weeks, suggesting the presence of binding interactions between the positively charged IGF-1 and negatively charged particles containing AA. The released IGF-1 was tested in dorsal root ganglion (DRG) neurite outgrowth assay and found to retain its biological activity for up to two weeks after encapsulation. Furthermore, the trophic effect of IGF-1 was tested with stem cell-derived V2a interneurons and found to have a synergistic effect when combined with neurotrophin-3 (NT3). To assess the potential of a combinatorial approach, IGF-1-releasing MPs were encapsulated within a hyaluronic acid (HA) hydrogel and showed promise as a dual delivery system. Overall, the PEG-DA MPs developed herein deliver bioactive IGF-1 for a period of weeks and hold potential to enable axonal growth of injured neurons via sustained release.

Decay study of Be11 with an optical time-projection chamber

The β decay of one-neutron halo nucleus Be11 was investigated using the Warsaw Optical Time Projection Chamber (OTPC) detector to measure β-delayed charged particles. The results of two experiments are reported. In the first one, carried out in LNS Catania, the absolute branching ratio for β-delayed α emission was measured by counting incoming Be11 ions stopped in the detector and the observed decays with the emission of α particle. The result of 3.27(46)% is in good agreement with the literature value. In the second experiment, performed at the HIE-ISOLDE facility at CERN, bunches containing several hundreds of Be11 ions were implanted into the OTPC detector followed by the detection of decays with the emission of charged particles. The energy spectrum of β-delayed α particles was determined in the full energy range. It was analyzed in the R-matrix framework and was found to be consistent with the literature. The best description of the spectrum was obtained assuming that the two 3/2+ and one 1/2+ states in B11 are involved in the transition. The search for β-delayed emission of protons was undertaken. Only the upper limit for the branching ratio for this process of (2.2±0.6stat±0.6sys)×10−6 could be determined. This value is in conflict with the result published by Ayyad [] but does agree with the limit reported by Riisager []. Published by the American Physical Society 2024

Creating High Yield Stress Particle-Laden Oil/Water Interfaces Using Charge Bidispersity.

Interfacial engineering has been increasingly used to stabilize Pickering emulsions in commercial products and biomedical applications. Pickering emulsion stabilization is aided by interfacial viscoelasticity; however, typically the primary means of stabilization are steric hindrances between high surface concentration shells of particles around the drops. In this work, the concept of creating large interfacial viscoelastic yield stresses with low particle surface concentrations (<50%) using bidisperse charged particle systems is tested to evaluate their potential efficacy in emulsion stabilization. To explore this hypothesis, interfacial rheology and visualization experiments are conducted at o/w interfaces using positively charged amidine, negatively charged carboxylate, and negatively charged sulfate-coated latex spheres and compared to a model based on interparticle forces. Bidisperse particle systems have been observed to create more networked structures than monodisperse systems. For surface concentrations of <50%, bidisperse interfaces created measurable viscoelastic moduli ∼1 order of magnitude larger than monodisperse interfaces. Furthermore, these interfaces have measurable yield stresses on the order of 10-4 Pa·m when monodisperse systems have none. Bidispersity impacts surface viscoelasticity primarily by increasing the overall magnitude of attraction between particles at the interface and not due to changes in the microstructure. The developed model predicts the relative surface fraction that creates the largest moduli and shows good agreement with the experimental data. The results demonstrate the ability to create large viscoelastic moduli for small surface fractions of particles, which may enable stabilization using fewer particles in future applications.

Recycling mixed polymer particles using a spiral tube tribo‐electrostatic separation device

AbstractAt present, research on the electrostatic separation of polymers is primarily concentrated in the WEEE field, with limited studies addressing the electrostatic separation of vehicle polymers. In this study, tribo‐charging separation of PA66/PP (modified)/PE three‐component vehicle polymer mixed particles was investigated using a spiral tube tribo‐charged separation device. Firstly, a force model of particle movement in the spiral tube was established, and the theoretical analysis determined that the critical rotational speed of particle centrifugal movement is 70 rpm. Secondly, the optimal charging parameters were determined by single‐factor experiments and orthogonal experiments, and the effect of the blanking baffle on the particle charging was also investigated. Finally, high‐voltage electrostatic separation simulations and experiments were carried out, achieving separation purities of 92.8% for PA66, 80.7% for PP (modified), and 86.6% for PE, respectively. Results provide both theoretical and experimental reference for one‐pass electrostatic separation of three kinds of plastic particles by spiral tube turbo‐charged separation device.Highlights Separation of vehicle polymers is crucial for its high‐value‐added recycling. A spiral tube tribo‐electrostatic separation device is developed. The critical rotational speed of particle centrifugal movement is analyzed. The influence of the blanking baffle on the particle charge is investigated.

Search for a resonance decaying to a W boson and a photon in proton-proton collisions at s\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$ \\sqrt{s} $$\\end{document} = 13 TeV using leptonic W boson decays

A search for a new charged particle X with mass between 0.3 and 2.0 TeV decaying to a W boson and a photon is presented, using proton-proton collision data at a center-of-mass energy of 13 TeV, collected by the CMS experiment and corresponding to an integrated luminosity of 138 fb−1. Particle X has electric charge ±1 and is assumed to have spin 0. The search is performed using the electron and muon decays of the W boson. No significant excess above the predicted background is observed. The upper limit at 95% confidence level on the product of the production cross section of the X and its branching fraction to a W boson and a photon is found to be 94 (137) fb for a 0.3 TeV resonance and 0.75 (0.81) fb for a 2.0 TeV resonance, for an X width-to-mass ratio of 0.01% (5%). This search presents the most stringent constraints to date on the existence of such resonances across the probed mass range. A statistical combination with an earlier study based on the hadronic decay mode of the W boson is also performed, and the upper limit at 95% confidence level for a 2.0 TeV resonance is reduced to 0.50 (0.63) fb for an X width-to-mass ratio of 0.01% (5%).

Dose increment in ultrashort particle irradiations via coherent stopping power

We present a relativistic self-consistent theory of the coherent stopping power (CSP) of ultradense charged particle beams propagating in a dense matter. CSP corresponds to a collective inelastic collision which adds to the ordinary stopping power of individual particles. Unlike the latter, which depends only on the particles' energy, CSP depends upon many more parameters such as the total charge of the ensemble and its charge density and shape. This paves the way for a broad variety of novel methods to tailor particle absorption and penetration in a dense matter. CSP losses can be explained both by collective excitations of single or multiple molecules and by the emission of coherent Cherenkov radiation. Here we demonstrate that the former mechanism is more relevant than the latter. We find that the coherent energy absorption of subpicosecond particle bunches in water occurs exciting a broad Debye process in the GHz range and an intermolecular stretching vibration mode in the THz region. We generalize the Bethe-Bloch stopping power formula to coherent effects including self-forces, dielectric screening, and absorption by the dense matter. For the sake of a self-consistent dynamical theory including phase space evolution, we have also generalized the Fermi-Eyges theory of particle diffusion to the presence of forces. Nonlinear dynamics is demonstrated, inducing nonlinear dose release, beam self-focusing, and self-enhancement of coherent losses. Given the advent of ultraintense particle sources and their use for biomedical and other relevant applications, our results may be of paramount importance for contemporary and future developments of science and technology. Published by the American Physical Society 2024

Yukawa couplings at infinite distance and swampland towers in chiral theories

We study limits of vanishing Yukawa couplings of 4d chiral matter fields in Quantum Gravity, using as a laboratory type IIA orientifolds with D6-branes. In these theories chiral fermions arise at brane intersections, where an infinite tower of charged particles dubbed gonions are localised. We show that in the limit Y → 0 some of these towers become asymptotically massless, while at the same time the kinetic term of some chiral fields becomes singular and at least two extra dimensions decompactify. For limits parametrised by a large complex structure saxion u, Yukawa couplings have a behaviour of the form Y ~ 1/ur, with r some positive rational number. Moreover, in this limit some of the gauge couplings associated to the Yukawa vanish. The lightest gonion scales are of order mgon ~ gsMP with s > 1, verifying the magnetic WGC with room to spare and with no need of its tower/sublattice versions. We also show how this behaviour can be understood in the context of the emergence of kinetic terms in Quantum Gravity. All these results may be very relevant for phenomenology, given the fact that some of the Yukawa couplings in the Standard Model are very small.

Creation and Expansion of Bioadhesive Transdermal Gel of Levobupivacaine Loaded Nanoparticles for Enhancement of Anesthetic Effect.

The present research work aimed to prepare a bioadhesive gel containing Levobupivacaine-loaded nanoparticles (NPs) to improve local anesthesia as transdermal patches were patient-friendly and easy to therapy. This study focuses on developing a The NPs were created using the ionotropic gelation method and assessed for particle charge, vesicle size and its distribution, and surface morphology. The improved NPs were incorporated into a gel and evaluated for their physicochemical assets. Among the NPs, NP4 was identified as the best based on its physicochemical properties. The NG-6 bioadhesive gel formulation stood out as the top gel among those tested. The NG-6 gel exhibited superior skin permeation ended 14 hours compared to other NPs. This bioadhesive transdermal gel with Levobupivacaine nanoparticles offers a promising approach to enhancing anesthetic effects.