Abstract With the rapid development of science and technology, computer-aided technology has been widely used in the field of education, but in the field of innovation and entrepreneurship education (Hereinafter referred to as IEE), there are still problems such as uneven distribution of resources and the disconnection between teaching content and actual needs. This paper puts forward a new model framework of computer-aided IEE, which is student-centered and practice-oriented. Through clear teaching objectives, rich course content, diverse teaching methods, and a scientific evaluation system, students’ innovative consciousness and entrepreneurial ability are comprehensively improved. The course covers innovative thinking, business models, market research, and other theoretical knowledge, and introduces virtual reality (VR) and augmented reality (AR) technologies to simulate the real entrepreneurial process and provide a practical platform. In the aspect of algorithm application, the research combines the content recommendation algorithm and collaborative filtering recommendation algorithm, constructs accurate user portraits by analyzing students’ learning behavior data, and matches them according to the characteristics of learning resources to recommend personalized learning resources for students. At the same time, the learning path optimization algorithm is developed, and the personalized and efficient learning path is planned by using the shortest path algorithm in graph theory to ensure that students can master the required knowledge in the shortest time. The experimental part designed a one-semester teaching experiment, and compared the differences between the experimental group and the control group in academic performance, learning participation, and satisfaction. The results show that the computer-aided IEE model significantly improves students’ academic performance, learning participation, and satisfaction, which verifies the effectiveness of the model. The research on the model and algorithm of computer-aided IEE proposed in this paper provides new ideas and methods for IEE, and helps to cultivate more high-quality talents with innovative thinking and entrepreneurial ability.