Motivated by scalar-tensor gravities, we consider a theory which contains massless scalar fields with different sound speeds. We derive unitarity relations for partial wave amplitudes of $2 \to 2$ scattering, with explicit formulas for contributions of two-particle intermediate states. Making use of these relations, we obtain unitarity bounds both in the most general case and in the case considered in literature for unit sound speed. These bounds can be used for estimating the strong coupling scale of a pertinent EFT. We illustrate our unitarity relations by explicit calculation to the first non-trivial order in couplings in a simple model of two scalar fields with different sound speeds.