The exceptionally large gold resource at Ladolam (>1,300 metric tons of gold), Lihir Island, resulted from the transition of an early-stage, low-grade porphyry gold system to a low-sulfidation epithermal gold event. This transition was probably triggered by rapid decompression during the partial slope failure of Luise stratovolcano and accompanied by the ingress of seawater. The original porphyry stage is indicated by remnant hydrothermal breccia clasts of strongly biotite–magnetite altered monzodiorite with disseminated pyrite ± chalcopyrite and poorly developed pyrite ± quartz stockwork veins. The breccias are overprinted by biotite–magnetite alteration and their matrix is strongly mineralized with disseminated auriferous pyrite. The breccias are cut by late-stage epithermal quartz–chalcedony–illite–adularia–pyrite veins and associated illite–adularia alteration that locally contain bonanza gold grades of up to 120 g/t. Isotope data suggest a magmatic source of sulfur in the gold-bearing fluids at Ladolam. Electronic supplementary material to this paper can be obtained by using the Springer LINK server located at http://dx.doi.org/10.1007/s00126-001-0230-y