Partial Molar Isentropic Compressibilities Research Articles

A study of enhancing the solubility of streptomycin sulphate in sorbitol using volumetric, acoustic and viscometric properties

The various molecular interactions present between streptomycin sulphate and sorbitol were evaluated using density (ρ), speed of sound (u) and viscosity (η) studies. All these studies have been obtained at different temperatures (300.15, 305.15, 310.15 ad 315.15) K and at 0.1 MPa pressure. The values obtained from these studies have been utilized to calculate the various thermodynamic parameters such as apparent molar volume (ΦV), apparent molar isentropic compression (ΦK), partial molar volume (ΦVo), partial molar isentropic compression (ΦKo), partial molar expansibility (ΦEo) of solute for SMS in various solutions of sorbitol. The data obtained from viscosity studies have been utilized to determine Falkenhagen coefficient (A), Jones- Dole coefficient (B), dB/dT and viscosity B-coefficient of transfer (Btr). A complete discernment into the physicochemical interactions present in the studied system have been redeemed through the scrutiny of above calculated parameters.

Structural elucidation of ternary mixtures of L‐valine/glycyl‐L‐valine and water + 1‐decyl‐3‐methylimidazolium bromide: Apparent molar properties at infinite dilution and expansivities

AbstractThis work comprises ternary systems of water + SAIL,1‐decyl‐3‐methylimidazolium bromide, and (S)‐2‐Amino‐3‐methylbutanoic acid generally identified as L‐valine/ (S)‐2‐(2‐Aminoacetamido)‐3‐methylbutanoic acid usually described as glycyl‐L‐valine, densities, and sound speed data have been computed at four operating temperatures, i.e., 288.15 to 318.15 K. Calculated density data have utilized for calculation of various thermodynamic parameters like Vϕ (apparent molar volume), (apparent molar volumes at infinite dilution), and calculated speed of sound statistics used to determine Kϕ,s (apparent molar isentropic compression), Ks (partial molar isentropic compression at infinite dilution). In our systems, the hydrophilic‐ionic interactions that are produced by co‐sphere overlap models are predominant. The Hepler's constant is used to analyze the solute's capacity to create or destroy solvent structures. The interaction parameter is computed using the McMillan‐Mayer theory. Understanding structure‐making, solvation characteristics, and numerous modifications in the ternary system of L‐valine/Glycyl‐L‐valine, water, and [C10MIm] [Br] is aided by a variety of thermodynamic factors.

Thermo-acoustic properties of monosaccharides D(−)-ribose and D(+)-xylose in aqueous diammonium hydrogen phosphate solutions at different temperatures

The volumetric and acoustic properties are used for investigating the interactions of polyhydroxy solutes D(−)-ribose and D(+)-xylose in different concentrations of diammonium hydrogen phosphate (DAP) solutions. Densities and speeds of sound of D(−)-ribose and D(+)-xylose in aqueous diammonium hydrogen phosphate (DAP) solutions have been measured over a temperature range of (298.15–318.15) K and at experimental pressure p = 0.1 MPa. Different parameters viz apparent molar volumes, Vϕ, partial molar volumes, apparent molar isentropic compression, partial molar isentropic compression, partial molar volume of transfer and molar isentropic compression of transfer are obtained using experimental density and ultrasonic speed data. The calculated parameters are discussed in rapports of solute–solvent interactions in solutions indicated the presence of ion-ion, ion-polar, hydrophilic-hydrophilic and hydrophobic–hydrophobic interactions in these ternary solutions, which was also confirmed from obtained positive values of apparent molar volume and negative values of apparent molar isentropic compressibility. Pair (VAB, KAB) and triplet (VABB, KABB) interaction coefficients determined by means of McMillan-Mayer theory are used to acquire valuable information about the dominance of pairwise interactions in the studied mixtures.

Volumetric-acoustic investigations of antihypertensive drug in aqueous acetaminophen system

Captopril is an antihypertensive drug used to lower the blood pressure in living organisms. In order to arbitrate and understand the synergy between antihypertensive drug viz., captopril and antipyretic drug acetaminophen in aqueous system, the density and sound velocity at different temperatures (293.15 to 318.15) K with temperature interval of 5 K were measured using Anton Paar density sound velocity meter (DSA5000M). The experimental measured data were further used to calculate volumetric and acoustic parameters such as apparent and partial molar volume, apparent and partial molar isentropic compressibility, partial molar expansibility, Hepler’s constant, compressibility hydration number, and intermolecular free length. Positive values of apparent molar volume (ϕv) and negative values of apparent and partial molar compressibility (ϕk and ϕko) of captopril in water and aqueous acetaminophen solution has been shown strong intermolecular interactions in solutions. Negative values of Hepler's constant indicate the structure breaking behavior of drug in water.

Acoustic and volumetric study of binary mixtures containing Ethyl propionate with amides at various temperatures

The development of biofuels to replace fossil fuels has recently increased at an exponential rate. Many chemical molecules with a wide range of functional groups make up biofuels. There is a strong correlation between the interactions between these molecules and the performance of biofuels. In this paper, the authors presented the new findings related to interactions existing in ethyl propionate and Formamide(F), N-Methylformamide (NMF), and N, N-Dimethylformamide (DMF) in a pure state as well as in their mixtures. Densities and speeds of sound at various temperatures (298.15–323.15 K) and at ambient pressure 0.1 MPa have been measured for these mixtures. From experimental data, the excess properties such as excess molar volume, VmE, excess isentropic compressibility, κsE, excess molar isentropic compressibility, Ks,mE, excess speed of sound, uE, and excess isobaric thermal expansivity, αpE, of the investigated mixtures were calculated. All the excess parameter values were fitted using the Redlich-Kister polynomial smoothing equation. The results were analysed in terms of molecular interactions. The excess partial molar volume, V¯m,1E, V¯m,2E , excess partial molar isentropic compressibility, K¯s,m,1EK¯s,m,2E over the whole composition range together with partial molar volume, V¯m,10, V¯m,20, partial molar isentropic compressibility K¯s,m,10, K¯s,m,20, excess partial molar volume, V¯m,10E, V¯m,20E and excess partial molar isentropic compressibility, K¯s,m,10E,K¯s,m,20E at infinite dilution have also been calculated from the experimental density measurements and analytically obtained using Redlich-Kister polynomials. The variations of these parameters with changes in composition and temperature have been discussed in terms of intermolecular interactions prevailing in these mixtures.

Thermodynamic and physicochemical characteristics of 2-butoxyethanol/2-phenoxyethanol in aqueous maltitol solutions

In this study, interactions occurring among solute and solvent in aqueous solutions containing maltitol and 2-butoxyethanol (2-BE) and 2-phenoxyethanol (2-PhE) as a solute were studied (Viz volumetric, acoustic and spectroscopic study). Density, ρ, and speed of sound,s, of 2-BE and 2-PhE in aqueous solutions of maltitol with concentrations (0.01, 0.02, and 0.03) mol∙kg-1 were measured at various temperatures ranging from 288.15 K to 308.15 K at 0.1 MPa.The data was used to calculate acoustic and thermodynamic parameters, such as the apparent molar volume (Vϕ), apparent molar isentropic compression (Kϕ,s), partial molar volume (Vϕ0) and partial molar isentropic compression at infinite dilution (Kϕ,s0). This analysis helped us understand the solvation behaviour of maltitol, which is a key component in sugar-free products. Additionally, the co-sphere overlap model was used to examine several intermolecular interactions in the ternary systems. We investigated the partial molar expansibilities (Eϕ0) and their first-order derivatives ∂Eϕ0/∂Tp to examine the solute's structure-making and structure-breaking properties. Finally, we also carried out spectroscopic studies for both binary and ternary mixtures. The observed molar properties indicate the presence of significant interactions between the solute and solvent components within the ternary mixture. This is further supported by the positive values of partial molar expansibility. Moreover, the partial molar properties of the mixture strongly imply the occurrence of hydrogen bond formation.

Physicochemical studies of propylene and hexylene glycols in methanol solutions of hexachlorophene at different temperatures

The current study investigates the molecular interactions of glycol molecules (propylene (PG) and hexylene (HG) glycols) in hexachlorophene solutions at different temperatures and experimental pressure 0.1 MPa by merging acoustic and thermodynamic processes. The density and speed of sound of liquid mixtures are measured using an Anton Paar DSA 5000 M. These experimental values are used to calculate a variety of thermodynamic and acoustic parameters. The apparent molar volume (Vϕ), partial molar volume (Vϕ0), apparent molar isentropic compression (Kϕ,s), and partial molar isentropic compression (Kϕ,s0) are calculated with the help of experimentally determined density and speed of sound, as well as the partial molar expansibility (Eϕ0) is also calculated. The apparent molar parameters show the existence of strong interactions between solute and solvent in the ternary mixture, and it is also supported by the positive partial molar expansibility data, whereas the partial molar parameters indicate the hydrogen bonding formation in the mixture.

Volumetric-acoustic study of Disodium Ethylenediaminetetraacetic acid with Propylene and Hexylene glycol at different temperatures

The present study shows the molecular interactions at constant pressure of 0.1 megapascals (MPa) and a range of temperatures from (288.15, 298.15, 308.15, 318.15 K) in aqueous solution of Disodium EDTA in (0.01, 0.02, 0.03) mol.kg-1 along with Propylene glycol and Hexylene glycol. Speed of sound and density data is determined using Anton Paar DSA 5000 M. Various thermo-acoustic parameters are calculated using the obtained data. Experimental density values determined apparent Molar Volume (Vϕ), Partial Molar Volume (Vϕ°) as well as Partial Molar Volume of Transfer (ΔVϕ°) along with Partial Molar Expansibility (Eϕ°) and thermal expansion coefficient (α). While speed of sound determined the Apparent Molar Isentropic Compression (Kϕ,S), Partial Molar Isentropic Compression (Kϕ,S°) as well as Partial Molar Isentropic Compression of Transfer (ΔKϕ.S°). Pair and Triplet Coefficients along with Empirical constants have also been estimated. FTIR spectroscopic research had been carried out in the binary mixture. From propylene through hexylene glycols, these factors provide data related to significant interactions between solute and solvent.

Influence of carbohydrates on the volumetric, acoustic and viscometric properties of thymine in aqueous solutions at different temperatures

Physicochemical studies of nitrogenous base, thymine in aqueous medium and in aqueous glucose/sucrose solutions have been determined at five different temperatures ranging (293.15 – 313.15) K, under atmospheric pressure (101.3) kPa. The experimentally obtained data of physical characteristics (density, sound speed and viscosity) have been employed to calculate the various densimetric, acoustic and rheological parameters like apparent molar volume (Vϕ), partial molar volume (Vϕo), limiting apparent molar expansibility (Eϕo), apparent molar isentropic compression (Kϕ,s), partial molar isentropic compression (Kϕ,so), viscosity B-coefficients, transfer properties (ΔtrVϕo, ΔtrKϕ,so and ΔtrB), hydration number (nH), etc. In addition, the Hepler’s thermodynamic relation has been utilized to determine the chaotropic nature of thymine in water and aqueous saccharides solutions. Finally, the co-sphere overlap model has been employed to access various prevalent intermolecular interactions in the considered systems. Additionally, UV spectral analysis confirmed the persistence of effective dipole–dipole interactions in the considered systems of study.

Volumetricand ultrasonic properties of thiamine hydrochloride drug in aqueous solutions of choline-based deep eutectic solvents at different temperatures

Important efforts have been made over the past years to improve the drug acts, which leads to the discovery of novel drug preparations and delivery systems. The optimal design of such processes requires a molecular-level understanding of the interactions between drug molecules and biological membranes. The thermodynamic investigation provides deep and complete knowledge of interactions and the choice of appropriate and suitable production compounds in pharmaceutical fields. Particularly, the analysis of drugs + co-solvents in aqueous media is the central issue in many types of research because they exert their impact by interacting with biological membranes. This work is aimed to measure the density and speed of sound for the thiamine hydrochloride in water + deep eutectic solvents (DESs) mixtures (choline chloride/urea, choline chloride/ethylene glycol and choline chloride/glycerol) at temperature range (293.15–308.15) K. By correlation of the evaluated parameters in some standard relations, the partial molar parameters i.e. apparent molar volumes, Vφ,m, and apparent molar isentropic compression, κs,φ,m, are calculated. In addition, apparent molar isobaric expansion, Eφ,m0, and Hepler’s constant are computed from the density and speed of sound data. For fitting the experimental Vφ,m and κs,φ,m the Redlich-Meyer equation was employed that the important quantities; standard partial molar volume, Vm0, and partial molar isentropic compression, κs,m0, were obtained. The thermodynamic analysis of the studied system also plays a crucial role in the pharmaceutical industry.

Study of molecular interactions in binary mixtures of 2-ethyl-1-hexanol with primary alcohols (propan-1-ol, 2- propen-1-ol and 2- propyn-1-ol) at various temperatures

ABSTRACT The densities (ρ), viscosities (η), and speeds of sound (u) were reported for binary mixtures of 2-ethyl-1-hexanol with aliphatic primary alcohols (propan-1-ol, 2-propen-1-ol, 2-propyn-1-ol) over the entire composition range from 303.15 K to 313.15 K and at atmospheric pressure 0.1 MPa. The excess parameters (VE,κs E), deviation in viscosity, excess partial molar volumes, ( and ) excess partial molar isentropic compressibility’s ( and ) of the components at infinite dilution were calculated from the densities, speeds of sound, and viscosities at experimental temperatures. The variation of these properties with composition of the mixtures suggests hydrogen bond and charge-transfer complex formation between 2-ethyl-1-hexanol and self-associated primary alcohols. The VE results have been analysed in the light of Prigogine-Flory-Patterson theory. An analysis of each of the three contributions, namely, interactional, free volume and P* to VE shows that interactional contribution was positive for all binary systems. The free volume effect and P* contribution were negative for all the mixtures. Furthermore, the FTIR spectra have been recorded at 298.15 K and found to be useful for understanding the presence of hydrogen bonding between dissimilar molecules in the liquid mixtures. A good agreement was obtained between excess quantities and spectroscopic data.

Investigating the Solvation Behavior of Some Lithium Salts in Binary Aqueous Mixtures of 1-Ethyl-3-methylimidazolium Tetrafluoroborate ([EMIM][BF4]) at Equidistant Temperatures (T= 298.15, 303.15, 308.15, 313.15, 318.15) K

In the current work, measurements of density, as well as speed of sound, were made to analyze the solvation behavior of some lithium salts in binary aqueous mixtures of 1-ethyl-3-methylimidazolium tetrafluoroborate ([EMIM][BF4]) at equidistant temperatures (T = 298.15, 303.15, 308.15, 313.15, 318.15) K and a pressure of 0.1 MPa. Various thermo-physical parameters like apparent and partial molar volumes (VØ and VØ0), apparent and partial molar isentropic compressions (KØ, S and KØ, S0), partial molar volume, and partial molar isentropic compression of transfer (ΔVØ0 and ΔKØ, S0) were calculated from the experimental data. McMillan–Mayer theory was used to calculate pairwise (AB) and triplet interactions (ABB) from the calculated coefficients. Based on the calculated parameters, the presence and paramountcy of solute-solvent synergy particularly hydrophilic interactions over hydrophobic interactions have been found for both LiClO4 and LiI in binary aqueous mixtures of [EMIM][BF4]. Furthermore, Hepler’s criterion has been employed to examine the potential of these salts as a structure maker/breaker.

Volumetric and Ultrasonic Studies of PEG200, PEG400, and Ethanol–Chlorhexidine Solutions at Various Temperatures

The density and sound velocity values for polyethylene glycols (PEGs) with molecular weights 200 and 400 in ethanol–chlorhexidine solutions were investigated at different temperatures, 288.15 to 318.15 K, and concentrations of 0.001, 0.003, and 0.005 mol·kg–1. The apparent molar properties and partial molar properties of ethanol–chlorhexidine solutions containing PEGs (200/400) were obtained using this experimental data. The thermodynamic parameters, such as apparent molar volume, (Vϕ), and limiting partial molar volume, (Vϕ0), are determined using density values obtained experimentally, whereas acoustic properties, such as apparent molar isentropic compression, (Kϕ, s), and limiting partial molar isentropic compression, (Kϕ, s0), are calculated using sound velocity values. These thermodynamic apparent and partial molar properties imply the occurrence of strong solute–solvent interactions. The temperature-dependent partial molar volume and partial molar expansibilities (Eϕ0) were also calculated. The presence of strong solute–solvent interactions has been discovered in the liquid mixtures.

The Group Contribution to the Function Derived from Density and Speed-of-Sound Measurements for Glymes in N,N-Dimethylformamide + Water Mixtures.

The density and speed of sound of pentaglyme and hexaglyme in the N,N-dimethylformamide + water mixture at four temperatures are presented. The limiting apparent molar volumes (VΦ,m0=Vm0), the isobaric molar thermal expansion (Ep,m0), the isentropic compressibility (κS), and the limiting partial molar isentropic compression (KS,Φ,m0 = KS,m0) were calculated. Changes in the values obtained from the physicochemical parameters, as functions of composition and temperature, were analyzed in terms of the molecular interactions and structural differentiation of the investigated systems. The hydrophobic hydration process of the studied glymes was visible in the area of high water content in the mixture. The hydration number of glymes in water at four temperatures was calculated and analyzed. The contribution of the -CH2- and -O- group to the functions describing the volume and acoustic properties of the investigated system was calculated. The calculated values of the functions analyzed using the group contribution are in agreement with the values obtained from the experimental data. Thus, such contributions are valuable for wide ranges of data, which can be used to analyze the hydrophobic hydration and preferential solvation processes, as well as to calculate the values of these functions for other similar compounds.

Thermodynamic study of calcium d-pantothenate drug in the presence of aqueous solutions including some amino acids: Volumetric and compressibility properties

The impressive and remarkable efforts have been made over the past years to improve the production, formulation and purification of active ingredients pharmaceutical which leads to the discovery of novel drug preparations and delivery systems. The optimal design of such processes requires a molecular-level understanding of the interactions between drug molecules and biological membranes. The thermodynamic investigation provides deep and complete knowledge of interactions and the choice of appropriate and suitable compounds in pharmaceutical fields. Particularly, the analysis of drugs + biomolecules in aqueous solutions is the central issue in many types of research because they exert their impact by interacting with biological membranes. This work is aimed to measure the density and speed of sound for the calcium d-pantothenate, vitamin B5 calcium salt (CDP) in aqueous solutions of amino acids (glycine, l-alanine, and l-leucine) at temperature ranges (293.15 to 308.15) K. By correlating of the measured physical quantities in with standard relations, apparent molar volumes, Vϕ,m, and apparent molar isentropic compression, κs,ϕ,m, are calculated. In addition, apparent molar isobaric expansion, Eϕ,m0, and Hepler’s constant are computed. For fitting the experimental Vϕ,m and κϕ the Redlich-Meyer equation was employed that the important quantities; standard partial molar volume, Vϕ0 , and partial molar isentropic compression, κϕ0, were obtained.

Evolution of solute–solvent interactions for aqueous 1-decyl-3-methylimidazolium bromide, [C10mim] [Br] solutions containing glycine/ glycylglycine through volumetric and acoustic studies

• New experimental density and speed of sound data have been collected. • Glycine/glycylglycine thermodynamic properties behaviour in aqueous IL has been examined. • Pair and Triplet interaction coefficient define the solute solvent interactions • The potential of co-solute to make and break structures has been interpreted. Volumetric and compressibility characteristics of ternary systems have been examined at temperatures T = 288.15 K−318.15 K at interval of 10 K and atmospheric pressure using vibrating tube densitometer DSA 5000 in order to investigate the interactions present in aqueous {glycine/glycylglycine + ionic liquid 1-decyl-3-methylimidazolium bromide} solutions. Using the experimental data for density, partial molar volume of transfer ( Δ V ϕ 0 ), limiting apparent molar volume ( V ϕ 0 ) have been computed. On the other hand speed of sound data utilized to calculate partial molar isentropic compression of transfer ( Δ K ϕ , S 0 ) and limiting apparent molar isentropic compression ( K ϕ , s 0 ). The ternary system's apparent molar and partially molar volumetric characteristics show that solute-solvent interactions prevail. The pair and triplet interaction coefficients determined from partial molar volumes of transfer and partial molar isentropic compression of transfer provide an explanation for the dominance of paired interactions.

Effect of [Bmim][Br] and [Emim][HSO4] on the solution properties of pyridoxine HCl at various temperatures: A physicochemical, thermodynamic and spectroscopic approach

The current paper is concerned with deliberation of physicochemical and thermodynamic parameters of pyridoxine HCl in water and binary aqueous (0.05, 0.10 and 0.15) mol kg−1 [Bmim][Br]/[Emim][HSO4] media by means of empirically acquired density, velocity of sound and viscosity data. These parameters have been evaluated for the examination of interactions prevailing between pyridoxine HCl and [Bmim][Br]/[Emim][HSO4] in aqueous medium over a temperature range (293.15 to 313.15) K and at 0.1 MPa pressure. The deliberated parameters include partial molar volumes (Vϕo), partial molar isentropic compressibilities (Kϕ,so), Jones-Dole coefficients (A and B) and thermodynamic parameters of viscous flow (Δμ10,Δμ20, ΔH20andTΔS20) etc. Further, apparent specific volume (ASV) has been studied for pyridoxine HCl in water and in aqueous IL systems, showing that the studied systems have sweet-bitter taste at all temperatures and compostions. Moreover, the trends corresponding to deviation in computed parameters have been analysed in light of the solute−solvent and solute−solute interactions prevailing in the systems. Additionally, UV spectral analysis has been carried out for the interpretation of interactions prevailing between pyridoxine HCl and [Bmim][Br]/[Emim][HSO4]. By the obtained results, we have inferred that there is dominance of ion-hydrophillic and hydrophilic-hydrophillic interactions in the investigational systems.

Explication of molecular interactions between leucine and pharmaceutical active ionic liquid in an aqueous system: Volumetric and acoustic studies

Ionic liquids and their performance for industrial objectives have focused on some of the most academic and scientific research efforts in the last decade. The densities and sound velocities of amino acid (L-leucine) in an aqueous solution of a pharmaceutically active ionic liquid 1-Butyl-3-methylimidazolium hexafluorophosphate [BMIm][PF6] were measured at different temperatures (293.15 K to 318.15 K) under atmospheric pressure. The experimental results were further used to compute apparent and partial molar volumes, partial molar expansion, Hepler’s constant, apparent and partial molar isentropic compression, alongwith corresponding empirical constants (Sv and Sk), intermolecular free length Lf and acoustic impedance Z. The negative values are obtained for partial molar volume of transfer, ΔtVΦo at all temperatures, and become more negative by increasing the concentration of ionic liquid which indicates predominance of strong electrostriction. The obtained values of these parameters show the structure-making/breaking ability of leucine in solutions of ionic liquid that favours solute–solvent interactions.

Solvation properties of 1-butyl 2, 3-dimethyl imidazolium chloride ionic liquid in aqueous and aqueous glycine solutions at different temperatures using volumetric and compressibility parameters

Volumetric and compressibility approaches were employed in this investigation to analyse the intermolecular interactions of 1-Butyl-2,3-dimethyl imidazolium chloride in aqueous, in 0.05 mol.kg−1 aqueous glycine and 0.1095 mol.kg−1 aqueous glycine solutions over the concentration range 0.01 to 0.13 mol.kg−1 at different temperatures i.e., T= (288.15,293.15, 298.15, 303.15, 308.15, 313.15 and 318.15) K and atmospheric pressure by measuring density(ρ) and speed of sound(u) data. Various thermophysical parameters such as apparent molar volume of solute(Vϕ), limiting apparent molar volume of solute(Vϕ0), transfer limiting apparent molar volume of soluteΔtrVϕ0, Hepler's constant (∂2Vϕ0/∂T2), isentropic compressibility (κS), apparent molar isentropic compression of solute (KS,ϕ), partial molar isentropic compression of solute(KS,ϕ0) and partial molar isentropic compression of transfer of solute ΔtrKS,ϕ0 have been calculated using the corresponding thermophysical data at studied temperatures. In addition, the temperature dependence of apparent molar volume of solute has been used to determine isobaric expansivity or thermal expansion coefficient(α), apparent molar expansivity of solute Eϕ and limiting apparent molar expansivity solute Eϕ0 parameters of binary and ternary systems. The findings were described in terms of solute–solute and solute–solvent interactions.

Compression of selected glymes in N,N-dimethylformamide + water. The hydration numbers and hydrophobic hydration process of glymes

This paper presents the speed of sound in selected glymes (monoglyme, diglyme, triglyme and tetraglyme) in N,N-dimethylformamide + water mixed solvent at four temperatures: 293.15 K, 298.15 K, 303.15 K and 308.15 K. The data obtained were used to calculate the values of isentropic compressibility (κS) of glymes solutions and apparent molar isentropic compression (KS,Φ,m), as well as the limiting partial molar isentropic compression (KS,m0) of glymes in the mixed solvent (DMF + W). Changes in the obtained values of the physicochemical parameters, as functions of temperature or mole fraction of water in the mixed solvent, were analyzed in terms of the molecular interactions and structural differentiation of the investigated systems. The hydrophobic hydration process of the studied glymes is visible in the high water content area of the mixed solvent. The hydration number of glymes in water at four temperatures was calculated and analyzed.