Volumetricand ultrasonic properties of thiamine hydrochloride drug in aqueous solutions of choline-based deep eutectic solvents at different temperatures

Abstract

Important efforts have been made over the past years to improve the drug acts, which leads to the discovery of novel drug preparations and delivery systems. The optimal design of such processes requires a molecular-level understanding of the interactions between drug molecules and biological membranes. The thermodynamic investigation provides deep and complete knowledge of interactions and the choice of appropriate and suitable production compounds in pharmaceutical fields. Particularly, the analysis of drugs + co-solvents in aqueous media is the central issue in many types of research because they exert their impact by interacting with biological membranes. This work is aimed to measure the density and speed of sound for the thiamine hydrochloride in water + deep eutectic solvents (DESs) mixtures (choline chloride/urea, choline chloride/ethylene glycol and choline chloride/glycerol) at temperature range (293.15–308.15) K. By correlation of the evaluated parameters in some standard relations, the partial molar parameters i.e. apparent molar volumes, Vφ,m, and apparent molar isentropic compression, κs,φ,m, are calculated. In addition, apparent molar isobaric expansion, Eφ,m0, and Hepler’s constant are computed from the density and speed of sound data. For fitting the experimental Vφ,m and κs,φ,m the Redlich-Meyer equation was employed that the important quantities; standard partial molar volume, Vm0, and partial molar isentropic compression, κs,m0, were obtained. The thermodynamic analysis of the studied system also plays a crucial role in the pharmaceutical industry.