Abstract Introduction Oral health is an integral part of general health. Systemic diseases such as diabetic condition and local factors have an impact on oral health of individuals. Dental caries is one of the most common oral health conditions affecting 60 to 90% of the population. Acrylic removable partial denture (RPD) is one of the most widely accepted means of tooth replacement. Its insertion in the mouth leads to altering the oral environment and increases plaque formation, particularly on tooth surface of those in contact with the acrylic partial denture facilitating the initiation of caries. Aim The aim of the study was to evaluate the effect of acrylic RPDs on caries prevalence in diabetic and nondiabetic patients. Methodology This comparative study was performed on 400 patients of age between 20 and 64 years visiting JSS Dental College and Hospital in Mysuru. Patients participating in this study were explained regarding the survey analysis and informed consent was taken. It was a questionnaire-based clinical study. Inclusion and exclusion criteria were considered for the selection of the study sample and categorize the patients into one of the following groups, with prostheses (Group A) and without prostheses (Group B) and subgroups diabetic patients with prostheses (Group A1) and nondiabetic patients with prostheses (Group A2). Diabetic patients without prostheses (Group B1) and nondiabetic patients without prostheses (Group B2). Sociodemographic information of each patient was recorded, and clinical examination was performed for decayed, missing, and filled teeth (DMFT) using DMFT index. Results A statistically significant high prevalence of dental caries was observed among nondiabetic patients with acrylic RPD (Group A2). Conclusion Acrylic RPD and diabetes had least role in caries prevalence.
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