Partial Correlation Research Articles

Neural Circuitry and Therapeutic Targeting of Depressive Symptoms in Schizophrenia Spectrum Disorders.

Conceptual similarities between depressive and negative symptoms complicate biomarker and intervention development. This study employed a data-driven approach to delineate the neural circuitry underlying depressive and negative symptoms in schizophrenia spectrum disorders (SSDs). Data from three studies were analyzed (157 participants with SSDs) to assess brain-behavior relationships: two neuroimaging studies and a randomized trial of repetitive transcranial magnetic stimulation (rTMS). Partial least squares correlation (PLSC) was used to investigate associations between resting-state functional connectivity and depressive and negative symptoms. Secondary analyses of rTMS trial data (active, N=37; sham, N=33) were used to assess relationships between PLSC-derived symptom profiles and treatment outcomes. PLSC identified three latent variables (LVs) relating functional brain circuitry with symptom profiles. LV1 related a general depressive symptom factor with positive associations between and within the default mode network (DMN), the frontoparietal network (FPN), and the cingulo-opercular network (CON). LV2 related negative symptoms (no depressive symptoms) via negative associations, especially between the FPN and the CON, but also between the DMN and the FPN and the CON. LV3 related a guilt and early wakening depression factor via negative rather than positive associations with the DMN, FPN, and CON. The secondary visual network had a positive association with general depressive symptoms and negative associations with guilt and negative symptoms. Active (but not sham) rTMS applied bilaterally to the dorsolateral prefrontal cortex (DLPFC) reduced general depressive but not guilt-related or negative symptoms. The results clearly differentiate the neural circuitry underlying depressive and negative symptoms, and segregated across the two-factor structure of depression in SSDs. These findings support divergent neurobiological pathways of depressive symptoms and negative symptoms in people with SSDs. As treatment options are currently limited, bilateral rTMS to the DLPFC is worth exploring further for general depressive symptoms in people with SSDs.

Enhancing Understanding of Eating Psychopathology: A Network Analysis Study

Compassion Focused Therapy for eating disorders (CFT-E) has been shown to be effective in treating eating psychopathology. Exploring which processes identified by the CFT-E model are most linked with eating disorder symptoms could help develop targeted treatments. However, the relationship between these variables requires further investigation. This study explores the interconnections between eating disorder symptoms and processes identified by the CFT-E using a network analysis approach. Participants were 497 individuals (77.3% female) from a community sample who completed measures to assess body dissatisfaction, shape and weight overvaluation, cognitive restraint, bingeing, emotional eating, purging, self-compassion, social comparison through appearance, self-criticism, appearance-related shame, guilt and pride, and positive and negative affect. A regularized partial correlation network was estimated. Appearance-related shame, inadequate self and body dissatisfaction emerged as the central nodes in the network. These findings support the use of interventions targeting shame and self-criticism for the treatment of eating disorder symptoms. Studies with diverse samples are needed to further examine the interconnections between eating psychopathology and the key processes identified by the CFT-E theoretical model.

Oxford Vaccine Hesitancy Scale (OVHS): a UK-based and US-based online mixed-methods psychometric development and validation study of an instrument to assess vaccine hesitancy

ObjectivesTo describe the development, validation and reliability of the Oxford Vaccine Hesitancy Scale (OVHS), a new instrument to assess vaccine hesitancy in the general population.DesignCross-sectional validation study.SettingInternet-based study with participants...

Abnormal Interhemispheric Functional Connectivity in Acute Pericoronitis: A Resting-State MRI Study.

Acute pericoronitis (AP) is a prevalent cause of odontogenic toothache which can significantly impact brain function. Previous research has predominantly concentrated on localized brain activity. However, the synergistic changes between brain hemispheres induced by toothache and resulting abnormal functional connectivity across the brain have not been comprehensively studied. A total of 34 patients with AP and 34 healthy individuals, matched for age, sex, and education were recruited for this study. All participants underwent resting-state functional magnetic resonance imaging (rs-MRI) scans. The voxel mirror homotopic connectivity (VMHC) method was used to identify intergroup differences. Brain regions exhibiting statistically significant differences were selected as regions of interest for further functional connectivity analysis. The partial correlation method was utilized to assess the correlation between abnormal VMHC values in different regions and clinical parameters, with age and sex included as covariates. Patients with AP exhibited reduced VMHC values in the thalamus and elevated VMHC values in the inferior frontal gyrus compared with healthy controls. Subsequent functional connectivity analyses revealed extensive changes in functional networks, predominantly affecting the default, frontoparietal, cerebellar, and pain networks. Changes in functional patterns across these brain networks offer novel insights into the neurophysiological mechanisms underlying pain information processing.

Altered Subcortical Brain Volume and Cortical Thickness Related to Insulin Resistance in Type 2 Diabetes Mellitus.

The objective of this study is to examine the alterations in subcortical brain volume and cortical thickness among individuals diagnosed with Type 2 diabetes mellitus (T2DM) through the application of morphometry techniques and, additionally, to investigate the potential association between these modifications and insulin resistance (IR). The present cross-sectional study comprised a total of 121 participants (n=48 with healthy controls [HCs] and n=73 with T2DM) who were recruited and underwent a battery of cognitive testing and structural magnetic resonance imaging (MRI). FreeSurfer was used to process the MRI data. Analysis of covariance compared discrepancies in cortical thickness and subcortical brain volume between T2DM and HCs, adjusting for the potential confounding effects of gender, age, education, and body mass index (BMI). Exploratory partial correlations investigated links between IR and brain structure in T2DM participants. Compared with HCs, individuals with T2DM demonstrated a cortical thickness decrease in the right caudal middle frontal gyrus, right pars opercularis, left precentral gyrus, and bilateral superior frontal gyrus. Furthermore, this study for T2DM found that the severity of IR was inversely related to the volume of the left putamen and left hippocampus, as well as the thickness of the left pars orbitalis, left pericalcarine, right entorhinal area, and right rostral anterior cingulate gyrus. The evidence for structural brain changes in T2DM was observed, and alterations in cortical thickness were concentrated in the frontal lobes. Correlations between IR and frontal cortical thinning may serve as a potential neuroimaging marker of T2DM and lead to various diabetes-related brain complications.

Influence of biphasic phenoxyethanol-alkaline pretreatment on the correlation between inter-structure and enzymatic hydrolysis in bamboo residues

The effective promotion of delignification (67.6 %) and xylan removal (44.8 %) from bamboo residues using a 2-phenoxyethanol/sodium hydroxide solution (P/A) system is demonstrated, while simultaneously enriching oligosaccharides contents of the pre-hydrolysate to 10.2 g/L. Increasing the P/A ratio from 0:1 to 4:1 improves the enzymatic digestibility of the substrates from 55.7 % to 70.1 % at 100 °C and from 73.8 % to 83.7 % at 120 °C. Furthermore, partial correlation analysis demonstrates that the physiochemical properties, including delignification, xylan removal, and crystallinity, show a significant positive correlation with enzymatic hydrolysis efficiency. Higher temperatures and P/A ratios during alkaline biphasic pretreatment promote the shrinkage of plant cells and delignification, with temperature being a particularly significant driver. These findings provide valuable insights into the alkaline and biphasic pretreatment of biomass and facilitate the optimization of the bio-refining system.

유아가 인식하는 자신의 놀이성: 교사의 평가 및 유아 실행 기능과의 관계

This study investigates young children’s self-perceived playfulness and explores the association with playfulness as assessed by teachers and the children’s executive functions. A sample of 183 preschoolers from childcare centers in the metropolitan area was selected purposively for one-on-one assessments to measure the children’s perceived playfulness and executive functions. Teachers were also asked to evaluate the playfulness of the children. Descriptive statistics, correlation analysis, independent sample t-tests, one-way ANOVA, and partial correlation analysis were conducted on the collected data. The results indicated that children generally perceived themselves as highly playful, and this perception was partially correlated with the teachers’ evaluations. No gender differences were found in the children’s self-perceived playfulness, but there were significant age-related differences within the groups. Moreover, a significant correlation was found between the children’s self-perceived playfulness and their executive functions. The findings suggest that children’s self-perceptions of their playfulness are related to both teachers’ assessments and their own executive functioning, thereby generalizing the tendencies observed in previous research where playfulness was assessed by adults such as teachers or parents.

Warming-induced soil moisture stress threatens food security in India.

Soil moisture (SM) interconnects various components of the Earth system and drives the land-atmosphere feedbacks and food production. However, around 40% of global vegetated land experiences SM drying. India is one of the global hotspots of land-atmosphere interactions and an extensively agrarian economy, but underexplored in terms of SM dynamics and its ramifications on food security. Here, we examine the mechanism of SM drying and its implications on cropland productivity in India based on remote sensing measurements and land surface model simulations in recent decades (2000-2019) and future projection of the 21st century. We find SM reduction predominantly in monsoon (4.5%) and winter (3%) seasons that areinthemajor agricultural seasonsofKharif and Rabi, respectively. Machine learning (ML)-based random forest (RF) reveals that temperature (T, 30.76%) is the dominant driver of SM variability, and then precipitation (P, 26.34%), evapotranspiration (ET, 26.08%) and surface greenness (16.82%). Concurrently, India experiences severe warming in terms of land (0.59 ℃/dec), soil (0.48 ℃/dec) and soil heat flux (SHF, 0.16 W/m2/dec) during 2000-2019. Partial correlation analysis between SM and T limiting the influence of P reveals a strong negative (> - 0.5) relationship in the agriculture intensive regions of Indo-Gangetic Plain (IGP) and South India (SI). Drying owing to warming and increased SHF, termed as warming-induced moisture stress, reduces gross primary productivity (GPP) (i.e. browning) and yield of major food crops of wheat, rain-fed rice, maize and soyabean, predominantly in SI and eastern IGP. Granger Causality shows that warming-induced soil moisture stress has a maximum temporal lag of 1month. In a warming world, the ever-growing population demands more food, and therefore, the warming-induced soil moisture stress is a serious threat to food security in India and similar agro-climatic regions of the world. This calls for climate-resilient agriculture, better agronomic management, improved irrigation and adoption of water-efficient crops.

THE IMPACT OF PRICE, PRODUCT QUALITY, AND ELECTRONIC WORD OF MOUTH ON PURCHASE DECISIONS FOR BENING’S KINCARE PRODUCTS IN KARAWANG

The objective of this study is to ascertain the impact of price, product quality, and electronic word of mouth on the purchasing decisions regarding Bening's skincare products in Karawang. Employing quantitative research with hypothesis testing, the research involved a sample of 105 consumers of Bening's Skincare products in Karawang.The analytical methods applied include multiple linear regression analysis, coefficient of determination (R2), partial correlation coefficient, t-test, F-test, and classical assumption tests using SPSS version 20 statistical software. Primary data for the study were obtained through a questionnaire. The findings of this research affirm that the price significantly influences the purchasing decisions for Bening's Skincare products in Karawang. Moreover, product quality plays a significant role in influencing the decision to purchase Bening's skincare products in Karawang. However, electronic word of mouth does not exhibit a significant impact on purchasing decisions for Bening's skincare products in Karawang. Additionally, the combined influence of price, product quality, and electronic word of mouth simultaneously affects the purchasing decisions for Bening's Skincare products in Karawang.

Power Distance and Indulgence Are Positively and Negatively Correlated with Ageism, Respectively: Evidence from 31 Countries

As the aging of the world accelerates, clarifying the relationship between cultural differences and ageism is an urgent issue. Therefore, in this study, we conducted a correlation analysis between the six cultural scales of Hofstede et al. and the two ageism scales calculated from data on 35,232 people from 31 countries included in the World Values Survey Wave 6 (WVSW6) by Inglehart et al. The results of a partial correlation analysis controlling for economic and demographic factors showed that power distance (PDI) and indulgence versus restraint (IVR) are positively and negatively correlated with ageism, respectively. This is the first study to show that these two cultural scales, which previous studies have not paid much attention to, are related to ageism.

The Relationship between Self-Concept and Job Satisfaction on the Performance of Private High School Teachers

This study aims to find out and analyze: (1) The relationship between self-concept and teacher’s performance, (2) the relationship between job satisfaction and teacher’s performance, (3) the relationship between self-concept and job satisfaction together on teacher’s performance. This study is quantitative research with partial correlation and multiple correlation methods. This research was conducted at a private high school in Seberang Ulu 1 District, Palembang with 89 teacher respondents. Data collection techniques are in the form of questionnaires and documentation. The validity test uses the validity of the construct while the reliability test uses Cronbranch Alpha. The prerequisite test for analysis uses the normality test, linearity test, multicollinearity test and the data are analyzed using partial correlation analysis and multiple correlation followed by the t-test. The results of this study showed that there was a significant relationship between self-concept and job satisfaction on the performance of private high school teachers in Seberang Ulu 1 District, Palembang with a correlation value of 0.533, the simultaneous contribution or contribution of self-concept and job satisfaction variables to teacher’s performance was 28.4% while 71.6% was determined by other variables.

Cortical microstructural alterations in different stages of Parkinson's disease.

To explore the cortical microstructural alterations in Parkinson's disease (PD) at different stages.149 PD patients and 76 healthy controls were included. PD patients were divided into early stage PD (EPD) (Hoehn-Yahr stage ≤ 2) and moderate-to-late stage PD (MLPD) (Hoehn-Yahr stage ≥ 2.5) according to their Hoehn-Yahr stages. All participants underwent two-shell diffusion MRI and the images were fitted to Neurite Orientation Dispersion and Density Imaging (NODDI) model to obtain the neurite density index (NDI) and orientation dispersion index (ODI) to reflect the cortical microstructure. We used gray matter-based spatial statistics method to compare the voxel-wise cortical NODDI metrics between groups. Partial correlation was used to correlate the NODDI metrics and global composite outcome in PD patients.Compared with healthy controls, EPD patients showed lower ODI in widespread regions, covering bilateral frontal, temporal, parietal and occipital cortices, as well as regional lower NDI in bilateral cingulate and frontal lobes. Compared with healthy controls, MLPD patients showed lower ODI and NDI in more widespread regions. Compared with EPD patients, MLPD patients showed lower ODI in bilateral temporal, parietal and occipital cortices, where the ODI values were negatively correlated with global composite outcome in PD patients.PD patients showed widespread cortical microstructural degeneration, characterized by reduced neurite density and orientation dispersion, and the cortical neuritic microstructure exhibit progressive degeneration during the progression of PD.

Characteristics of locus coeruleus functional connectivity network in patients with comorbid migraine and insomnia

BackgroundMigraine and insomnia are prevalent conditions that often co-occur, each exacerbating the other and substantially impacting the quality of life. The locus coeruleus (LC), a brainstem region responsible for norepinephrine synthesis, participates in pain modulation, sleep/wake cycles, and emotional regulation, rendering it a potential nexus in the comorbidity of migraine and insomnia. Disruptions in the LC-noradrenergic system have been hypothesized to contribute to the comorbidities of migraine and insomnia, although neuroimaging evidence in humans remains scarce. In this study, we aimed to investigate the intrinsic functional connectivity (FC) network of the LC in patients with comorbid migraine and subjective chronic insomnia and patients with migraine with no insomnia (MnI) using resting-state functional magnetic resonance imaging (rs-fMRI) and seed-based FC analyses.MethodsIn this cross-sectional study, 30 patients with comorbid migraine and chronic insomnia (MI), 30 patients with MnI, and 30 healthy controls (HCs) were enrolled. Participants underwent neuropsychological testing and rs-fMRI. The LC-FC network was constructed using seed-based voxel-wise FC analysis. To identify group differences in LC-FC networks, voxel-wise covariance analysis was conducted with sex and age as covariates. Subsequently, a partial correlation analysis was conducted to probe the clinical relevance of aberrant LC-FC in patients with MI and MnI.ResultsExcept for the insomnia score, no other significant difference was detected in demographic characteristics and behavioral performance between the MI and MnI groups. Compared with HCs, patients with MI exhibited altered LC-FC in several brain regions, including the dorsomedial prefrontal cortex (DMPFC), anterior cerebellum, dorsolateral prefrontal cortex (DLPFC), thalamus, and parahippocampal gyrus (PHG). Lower FC between the LC and DLPFC was associated with greater insomnia severity, whereas higher FC between the LC and DMPFC was linked to longer migraine attack duration in the MI group.ConclusionOur findings reveal the presence of aberrant LC-FC networks in patients with MI, providing neuroimaging evidence of the interplay between these conditions. The identified LC-FC alterations may serve as potential targets for therapeutic interventions and highlight the importance of considering the LC-noradrenergic system in the management of MI.

Estimating the dynamics and driving factors of gross primary productivity over the Chinese Loess Plateau by the modified vegetation photosynthesis model

Gross primary productivity (GPP) is a key parameter in research on the global carbon cycle and changes. Understanding the spatiotemporal dynamics and influencing factors of GPP on the Loess Plateau (LP) helps identify the health status of ecosystems, thereby enabling the implementation of effective conservation and restoration measures. In this study, we used a modified vegetation photosynthesis model (VPM) to simulate a long-term series of GPP in the LP from 2001 to 2022, and the impacts of different land-use patterns and meteorological factors on GPP were investigated using a transition matrix, linear regression, and partial correlation analyses. The findings suggested that the modified simulation yielded a more reliable performance (coefficient of determination (R2) = 0.89, root mean square error (RMSE) = 143.47 gC·m−2·yr−1) and was suitable for further research endeavors. (1) The GPP on the LP significantly increased by 232.65 TgC from 2001 to 2022. The southeastern region contributed more than the northwestern region, and the GPP exhibited higher multi-year averages and growth rates below 1000 m elevation. (2) Forests in the southeastern region of the LP, characterized by a heightened growth rate, will influence future spatial variations in GPP increases across the LP. Despite the decline in grassland and cultivated land areas, substantial land coverage has significantly contributed to the overall GPP growth. Urbanization encroaching on cultivated land has emerged as a key contributor to the decline in GPP in low-altitude regions. (3) Air temperature was the main physical driving force for GPP change in the LP. Additionally, the GPP in forested regions exhibited a negative correlation with rainfall, whereas the GPP in areas undergoing the return of cropland to forest–grassland and cropland reclamation correlated negatively with solar radiation. (4) The attribution analysis indicated that the surge in vegetation GPP on the LP was collectively driven by human activities and meteorological changes, with human activities dominating these changes by 61.41 %. This study deepens the understanding of terrestrial ecology in semi-humid regions and provides scientific insights for implementing ecological governance strategies in the LP.

Relationship between ultrasonographic findings and subscales of the Knee Injury and Osteoarthritis Outcome Score in patients with early knee osteoarthritis: a multicenter study.

To characterize the ultrasonographic findings of patients with early knee osteoarthritis (KOA) and determine which findings were associated with the Knee Injury and Osteoarthritis Outcome Score (KOOS) subscale. The study included 98 knees (35 men, 63 women, 60.3 ± 11.5 years) diagnosed with early KOA with no major deformity radiographically, but with pain during activity and tenderness in the medial knee. Synovial hyperplasia in the suprapatellar bursa, knee joint effusion, horizontal tear of the medial meniscus (MM), osteophytes of the medial condyle of the femur and tibia, blood flow signals in the synovium of the suprapatellar bursa, medial collateral ligament bursa, infrapatellar fat pad, MM extrusion (MME) in the supine and upright positions, and the amount of change in MME were observed using ultrasonography. Correlations (p < 0.05) were found between the presence of synovial hyperplasia of the suprapatellar bursa (r<-0.20) and amount of MME in the upright position (r< - 0.24) and all KOOS subscales. Presence of joint effusion and the four KOOS subscales except quality of life (QOL) were correlated (p < 0.05). Partial correlation coefficients showed correlations (p < 0.05) between knee joint effusion and symptoms (r = 0.299) and activities of daily living (ADL) (r = 0.254) of the KOOS subscales, and between MME in the upright position and symptoms (r= - 0.263), pain (r= - 0.256), and ADL (r= - 0.212). Quality and difficulty of life of patients with early KOA may be influenced by synovial hyperplasia in the suprapatellar bursa, joint effusion, and MME values in the upright position. Among them, synovial hyperplasia of the suprapatellar bursa and amount of MME in the upright position were independently associated with the KOOS subscales.

Dynamic evolution of frontal-temporal network connectivity in temporal lobe epilepsy: A magnetoencephalography study.

Temporal lobe epilepsy (TLE) frequently involves an intricate, extensive epileptic frontal-temporal network. This study aimed to investigate the interactions between temporal and frontal regions and the dynamic patterns of the frontal-temporal network in TLE patients with different disease durations. The magnetoencephalography data of 36 postoperative seizure-free patients with long-term follow-up of at least 1 year, and 21 age- and sex-matched healthy subjects were included in this study. Patients were initially divided into LONG-TERM (n = 18, DURATION >10 years) and SHORT-TERM (n = 18, DURATION ≤10 years) groups based on 10-year disease duration. For reliability, supplementary analyses were conducted with alternative cutoffs, creating three groups: 0 < DURATION ≤7 years (n = 11), 7 < DURATION ≤14 years (n = 11), and DURATION >14 years (n = 14). This study examined the intraregional phase-amplitude coupling (PAC) between theta phase and alpha amplitude across the whole brain. The interregional directed phase transfer entropy (dPTE) between frontal and temporal regions in the alpha and theta bands, and the interregional cross-frequency directionality (CFD) between temporal and frontal regions from the theta phase to the alpha amplitude were further computed and compared among groups. Partial correlation analysis was conducted to investigate correlations between intraregional PAC, interregional dPTE connectivity, interregional CFD, and disease duration. Whole-brain intraregional PAC analyses revealed enhanced theta phase-alpha amplitude coupling within the ipsilateral temporal and frontal regions in TLE patients, and the ipsilateral temporal PAC was positively correlated with disease duration (r = 0.38, p <.05). Interregional dPTE analyses demonstrated a gradual increase in frontal-to-temporal connectivity within the alpha band, while the direction of theta-band connectivity reversed from frontal-to-temporal to temporal-to-frontal as the disease duration increased. Interregional CFD analyses revealed that the inhibitory effect of frontal regions on temporal regions gradually increased with prolonged disease duration (r = -0.36, p <.05). This study clarified the intrinsic reciprocal connectivity between temporal and frontal regions with TLE duration. We propose a dynamically reorganized triple-stage network that transitions from balanced networks to constrained networks and further develops into imbalanced networks as the disease duration increases.

The moderation effect of morphological awareness on the relationship between word detection skills and reading comprehension in Chinese children with and without dyslexia

AbstractThis study aimed to investigate the moderating effect of morphological awareness on the relationship between word detection skills and reading comprehension in Chinese children with and without dyslexia. The study included 116 Chinese children in third to sixth grades, with 60 children diagnosed with dyslexia and 56 matching typically developing children. ANCOVAs revealed significant group differences in word detection skills and morphological awareness, with children with dyslexia performing significantly worse than their typically developing peers. Partial correlation analyses showed significant correlations between reading comprehension and morphological awareness in typically developing children and between reading comprehension and both word detection skills and morphological awareness in children with dyslexia. Moderation analyses revealed that morphological awareness significantly moderated the relationship between word detection skills and reading comprehension in both groups. For typically developing children, the relationship was significant at higher levels of morphological awareness, while for children with dyslexia, the relationship was significant at lower levels of morphological awareness. The findings suggest that word detection skills may serve as a compensatory mechanism for children with dyslexia when morphological awareness is at lower levels, highlighting the need for targeted interventions and individualised approaches to reading instruction.

Retinal Microvasculature Changes Linked to Executive Function Impairment after COVID-19

Background/Objectives: Studies using optical coherence tomography angiography (OCTA) have revealed that individuals recovering from COVID-19 have a reduced retinal vascular density (VD) and larger foveal avascular zones (FAZs) than healthy individuals, with more severe cases showing greater reductions. We aimed to examine aspects of the retinal microvascularization in patients with post-COVID-19 condition (PCC) classified by COVID-19 severity and how these aspects relate to cognitive performance. Methods: This observational cross-sectional study included 104 PCC participants from the NAUTILUS Project, divided into severe (n = 59) and mild (n = 45) COVID-19 groups. Participants underwent cognitive assessments and OCTA to measure VD and perfusion density (PD) in the superficial capillary plexus (SVP) and FAZ. Analysis of covariance and partial Pearson and Spearman correlations were used to study intergroup differences and the relationships between cognitive and OCTA variables. Results: Severe PCC participants had significantly lower central (p = 0.03) and total (p = 0.03) VD, lower central (p = 0.02) PD measurements, and larger FAZ areas (p = 0.02) and perimeters (p = 0.02) than mild cases. Severe cases showed more cognitive impairment, particularly in speed processing (p = 0.003) and executive functions (p = 0.03). Lower central VD, lower central PD, and larger FAZ areas and perimeters were associated with worse executive function performance in the entire PCC sample and in the mild COVID-19 group. Conclusions: Retinal microvascular alterations, characterized by reduced VD and PD in the SVP and larger FAZ areas, were associated with cognitive impairments in PCC individuals. These findings suggest that severe COVID-19 leads to long-lasting microvascular damage, impacting retinal and cognitive health.

Hydraulic impact of pressure transients from water conveyance tunnel on the complex hydrogeological system: A case study HPP Pirot, Serbia

Hydraulic tunnels, integral components of hydropower plant (HPP) systems, traversing diverse rock masses, pose challenges for long-term operation. The study’s main goal was to investigate how hydraulic transients originating from the headrace tunnel transfer through the concrete lining and manifest in surrounding aquifer systems. In this experimental study at the water pressure tunnel of HPP Pirot (Serbia), a novel monitoring approach was employed. The internal piezometers with highly sensitive probes are distributed strategically along the tunnel in different geological environments. This approach involved monitoring of water pressure in the surrounding rock masses and observing the impact of hydraulic transients generated by HPP operation. A comprehensive analysis of monitoring data, incorporating ordinal and partial correlations and considering geological features, provides a profound understanding of groundwater dynamics, pressure transient phenomena, and hydrogeological characterization during HPP operation. The study highlights the complex and spatially diverse hydrogeological environment, emphasizing the varying reactivity of pore pressure during HPP operation, particularly concerning Water Mass Oscillations (WMO). Reactive piezometers near the surge tank demonstrate significant pressure variations, while those located further away display synchronous pressure changes with reduced amplitudes. Schematic hydrogeological models have been created based on the hydraulic impacts of HPPs in different geological environments along the tunnel route. The water pressure response enabled aquifer characterization of (1) a thin-layered, low-fissured aquifer closely related to the reservoir, with low influence on WMO transients; (2) a low-fissured, compartment aquifer or non-aquifer with minimal to no influence on WMO transients; (3) a well-structured karst aquifer system influenced by WMO transients; (4) a fault-controlled zone of deep hypogene karst aquifer discharge highly influenced by WMO transients; and (5) an aquifer with a dominant development of the karst conduit system highly influenced by WMO transients. The study highlights the significance of monitoring water pressure within the rock mass as a fundamental element in analyzing the interaction between water pressure tunnels and the hydrogeological environment. Applying the presented instrumentation and methodology facilitates effective monitoring in research areas where pressure tunnels are constructed.

Weight Assignment Method and Application of Key Parameters in Shale Gas Resource Evaluation

The evaluation methods for shale gas resources and the key parameters involved are diverse. The main research object of this article is the key parameters in shale gas resource evaluation, and this study aims to quantitatively evaluate the required key parameters for calculation, thereby improving the credibility of shale gas resource evaluation results. This article mainly analyzes the weight analysis of the key parameters used in the resource evaluation process, focusing on the analysis and determination of key parameters controlling the generation, enrichment, and preservation of shale gas. The key parameters are graded and evaluated layer by layer, and the common key parameters that participate in the determination are extracted. Based on the above analysis, a weight conversion model is proposed to quantitatively evaluate the actual importance of key parameters in resource evaluation. By combining statistical research, the partial correlation coefficients in the correlation coefficients are applied to estimate the resource quantities in the exploration field in order to quantitatively evaluate the credibility of the resource evaluation results. This article focuses on the weight assignment of key parameters for calculating the resource quantity of the Jiaoshiba shale gas field in the Fuling area of Chongqing and obtains different weight results for different parameters. Using this method to assign key parameter weights to the target block can provide reliable parameter support for shale gas resource evaluation and provide strong support for shale gas resource estimation.