Genetic testing and genetic research in general are especially powerful in population studies. Genetic research can assess human genetic variation within and between populations, as well as potentially identify specific genetic determinants of disease. In the United States, isolated indigenous communities are genetically unique compared with an ever-growing homogenous population (Santos, 2008). The current dialogue surrounding population studies continues to develop among both researchers and the communities that are highly sought after for such studies, which include Native American Indian (AI) and Alaska Native (AN) tribes. In efforts to further engage in the conversation regarding the intersection of native peoples and genetic research, the National Congress of American Indians, in collaboration with the National Human Genome Research Institute and the National Museum of the American Indian, hosted a symposium in June 2014. The symposium, titled ‘‘A Spectrum of Perspectives: Native Peoples and Genetic Research,’’ was held at the Smithsonian National Museum of the American Indian in Washington, D.C. Although native people’s perspectives with regard to genetic research are by no means uniform, many tribes approach genetic research with hesitancy and fear attributable to a legacy of western exploitation and ethical misconduct. Many research studies in the past have limited the input of native people and disregarded their traditions, thus causing many tribes to feel like ‘‘guinea pigs’’ participating in studies that didn’t benefit them (Fong et al., 2003). Accordingly, as reflected at the symposium, many new questions have been raised across the United States among the AI and AN people as a way to address the concerns of their tribes and to demand greater collaboration in genetics research. One of the main concerns among native people is a lack of clarity about the motivations behind genetic research and the question of direct benefits to their tribe. These concerns heightened in the early 1990s when the Havasupai, an AI tribe, teamed with Arizona State University to participate in a research project that was intended to help explain the high rates of type 2 diabetes in their community (Santos, 2008). In accordance with the study, the Havasupai provided blood samples and fingerprints. By the end of the decade, the Havasupai had received little to no information regarding the study and were told their samples were damaged because of a freezer failure. However, not all the blood samples were destroyed, and instead of receiving permission from the Havasupai, the research team sent the blood samples to other universities. Genetic research continued, and the Havasupai were neither consented for the sample sharing nor informed about the findings of these new studies. As a result, the community filed lawsuits against Arizona State University for the violation of their civil rights (Santos, 2008). As demonstrated by this example, the Euro-American tradition of research traditionally involves the extraction of data from a population using experts, which is then analyzed and processed elsewhere. This tradition of research is rather undesirable because it lacks an overall feedback component. However, many natives people do support research that is reciprocal and benefits the health of their community. Rather than relying on researchers to shift their framework away from the Euro-American tradition, many tribes have begun to demand greater control in the scientific process. The Kahnewake Mohawk community in Canada reflects an increasing initiative taken by tribes to engage in research through their development of a diabetes intervention program, which includes both a dietary and a physical component (Bowekaty and Davis, 2003). In addition, many AI and AN tribes are apprehensive about the handling and treatment of individuals’ biospecimens. Although each tribe has different values and spiritual beliefs, biospecimens carry a great deal of value. Dr. Frank Dukepoo (Hopi tribe), a geneticist at Northern Arizona University, demonstrated this value in an interview with the San Francisco Chronicle: ‘‘To us, any part of ourselves is sacred. Scientists say its just DNA. For an Indian, it is not just DNA, it’s part of a person, it is sacred, with deep religious significance. It is part of the essence of a person’’ (Petit, 1998). When researchers approach native people, they follow a framework that is distinct to that community’s cultural, historical, political, and spiritual identities. These various cultural nuances and specific spiritual traditions must be regarded in scientific research because their significance bears a heavy weight for the population under study. Native people also face anxiety over postulating how genetic research could harm the tribe. Some studies have the potential to question cosmologic views or migration patterns, which could ultimately challenge traditional beliefs, such as