Background and Aims: Laparoscopic cholecystectomy is widely performed, and has replaced open cholecystectomy as the gold standard for cholelithiasis. Postoperative abdominal and visceral pain after elective Laparoscopic Cholecystectomy is of prime concern to patients as it causes signicant distress. The aim was to evaluate the benet of intraperitoneal instillation of Ropivacaine versus bupivacaine on postoperative pain after Laparoscopic Cholecystectomy when used as a part of multimodal analgesia. A Material And Method: fter ethical committee approval and written informed consent, 60 patients of ASA1 and 2, aged between 18 to 60 years of either genders. Group Bupivacaine (B): received intraperitoneal instillation of 20 ml of plain bupivacaine 0.5%. Group Ropivacaine (R): received 20 ml of 0.75% ropivacaine. Result: There was statistically signicant difference in VAS score at 2 and 4 hrs postoperatively (p<0.05). The incidence of PONV was not statistically signicant between the groups (P = 0.1 and p = 0.09, respectively). Shoulder pain was seen in 17 patients in Group B and seven patients in Group R, which was statistically signicant (P = 0.04) We conclude that the intraperitoneal Conclusion: and sub diaphragmatic instillation of 0.75% ropivacaine is a safe and effective method for providing postoperative analgesia without signicant side effects.