Sjogren’s syndrome is an infrequent but extremely symptomatic condition which occurs primarily in postmenopausal females. The classic triad of dry eyes, dry mouth, and an associated autoimmune disease is not always clinically apparent and the diagnosis of the syndrome becomes problematic [1], Clinical diagnosis usually depends on a strong positive history for keratoconjunctivitis sicca (KCS) and on typical signs including Rose Bengal staining, fluorescein staining, and tear breakup time (TBUT) [2]. Ocular findings may be correlated with oral symptoms of xerostomia and documented by decreased parotid flow rate (PFR) [3], as well as by rheumatologie evaluation and correspondingly abnormal serologic tests (SS-A, SS-B, ANA, and Rheumatoid Factor) [4], Even though several ocular tests, including tear osmolarity, cellulose acetate impression cytology and tear fluorescein dilution tests have been proposed as the “gold standard” for diagnosing Sjogren’s syndrome, we propose that labial salivary gland (LSG) biopsy should be considered as the basic standard by which all other diagnostic criteria are compared.