Sample Of Parents Research Articles

Long-read sequencing for detection and subtyping of Prader-Willi and Angelman syndromes

Prader-Willi syndrome (PWS) and Angelman syndrome (AS) are imprinting disorders caused by genetic or epigenetic aberrations of 15q11.2-q13. Their clinical testing is often multitiered; diagnostic testing begins with methylation-specific multiplex ligation-dependent probe amplification or methylation-sensitive PCR and then proceeds to molecular subtyping to determine the mechanism and recurrence risk. Currently, correct classification of a proband’s PWS/AS subtype often requires parental samples, a costly process for families and health systems. The use of nanopore sequencing for molecular diagnosis of PWS and AS has been explored by Yamadaet al; however, to confirm heterodisomy parental data were still required. Here, we investigate genome-wide nanopore sequencing in a larger cohort of PWS (18) and AS (6) as a singular test to detect the molecular subtype, without parental data. We accurately subtyped these cases including uniparental heterodisomy, mixed iso-/heterodisomy, type 1 and 2 deletions, microdeletion andUBE3Aindels. One PWS case with a previously unresolved diagnosis subtyped as maternal isodisomy. This work highlights the application of long-read sequencing and other imprinted regions outside of the PWS/AS critical region to resolve the molecular diagnosis and subtyping of PWS and AS without parental data. The work also outlines an approach to generically detect heterodisomy through the interrogation of distant imprinted regions.

X-ray AGN in Boötes: The lack of growth of the most massive black holes since z = 4

Abstract Supermassive Black Holes (BHs) are known to efficiently grow through gas accretion, but even sustained and intense mass build-up through this mechanism struggles to explain the assembly of the most massive BHs observed in the local Universe. Using the Chandra Deep-Wide Field Survey (CDFWS) in the Boötes field, we measure BH–galaxy assembly in massive galaxies ($M_\star \gtrsim 10^{10}\rm M_\odot$) through the AGN fraction and specific Black Hole accretion rate (sBHAR) distribution as a function of redshift and stellar mass. We determine stellar masses and star formation rates for a parent sample of optically selected galaxies as well as those with X-ray detections indicating the presence of an AGN through Spectral Energy Distribution (SED) fitting. We derive a redshift-dependent mass completeness limit and extract X-ray information for every galaxy as to provide a comprehensive picture of the AGN population in massive galaxies. While X-ray AGN samples are dominated by moderately massive host galaxies of $M_{\star } \geqslant 10^{10}\rm M_{\odot }$, we do not find a strong stellar mass dependence in AGN fraction (to limits in sBHAR), indicating a bias towards massive galaxies in the observed samples. We derive BH-galaxy growth tracks over time, which reveal that while most BH mass has been accumulated since z = 4 for lower mass BHs, the assembly of the most massive BHs is more complex, with little to no relative mass gain since z = 4, implying that rapid and intense growth episodes prior to z = 4 were necessary to form these massive BHs.

Is being a physically active parent related to having a physically active son/daughter?

Abstract Background Engaging in physical activity (PA) during childhood and adolescence can promote lifelong healthy habits and improve overall health. Physically active parents could play a key role in influencing the sons’ and daughters’ PA. The study aimed to evaluate the levels of PA among children and adolescents and to investigate the possible relationship with PA levels of parents. Methods This cross-sectional study involved a random sample of parents of a son/daughter aged 5 to 17 years in the Southern part of Italy. Data were collected through an anonymous self-administered questionnaire designed to retrieve i) sociodemographic characteristics and anthropometric data, ii) parent’s knowledge about the World Health Organization’s (WHO) guidelines (GL) about PA, iii) levels of PA of son/daughter and parent. Results Preliminary findings refer to a sample of 230 parents, of whom, 52.2% were women with a mean age of 38.6 (SD ± 6.8) years. The vast majority of the sample was employed (79.6%) and married (89.1%). Less than half (48.7%) were knowledgeable about WHO’s GLs for PA both in adults (52.6%) and children/adolescents (74.8%). Almost two-thirds (63%) of parents practised PA according to WHO’s GLs. Among sons/daughters, 44.4% practised PA according to WHO’s GLs. The results of the multivariate analysis showed that sons/daughters of physically active parents had higher odds of practising PA according to WHO’s GLs (OR:6.48, 95%CI:3.29-12.79). Similarly, those with parents knowledgeable about WHO’s GLs for PA (OR:3.19, 95%CI:1.75-5.83) were more likely to practise PA according to WHO’s GLs. Conclusions Preliminary results reveal a lack of compliance with WHO’s GL on PA, especially among children and adolescents. This is of concern since it is linked to negative health outcomes in the future. The figure that sons/daughters of active parents had a higher likelihood of being active highlights that public health organizations should prioritise family-based interventions for PA. Key messages • Almost one-third of adults and more than half of the children and adolescents in the sample did not comply with WHO’s recommendations for physical activity. • Sons and daughters of physically active parents are more likely to be active, prompting the need for family-based public health intervention to promote physical activity.

Survey of gravitationally lensed objects in HSC imaging (SuGOHI) – X. Strong lens finding in the HSC-SSP using convolutional neural networks

ABSTRACT We apply a novel model based on convolutional neural networks (CNN) to identify gravitationally lensed galaxies in multiband imaging of the Hyper Suprime-Cam Subaru Strategic Program (HSC-SSP) Survey. The trained model is applied to a parent sample of 2350 061 galaxies selected from the $\sim$ 800 deg$^2$ Wide area of the HSC-SSP Public Data Release 2. The galaxies in HSC Wide are selected based on stringent pre-selection criteria, such as multiband magnitudes, stellar mass, star formation rate, extendedness limit, photometric redshift range, etc. The trained CNN assigns a score from 0 to 1, with 1 representing lenses and 0 representing non-lenses. Initially, the CNN selects a total of 20 241 cutouts with a score greater than 0.9, but this number is subsequently reduced to 1522 cutouts after removing definite non-lenses for further visual inspection. We discover 43 grade A (definite) and 269 grade B (probable) strong lens candidates, of which 97 are completely new. In addition, we also discover 880 grade C (possible) lens candidates, 289 of which are known systems in the literature. We identify 143 candidates from the known systems of grade C that had higher confidence in previous searches. Our model can also recover 285 candidate galaxy-scale lenses from the Survey of Gravitationally lensed Objects in HSC Imaging (SuGOHI), where a single foreground galaxy acts as the deflector. Even though group-scale and cluster-scale lens systems are not included in the training, a sample of 32 SuGOHI-c (i.e. group/cluster-scale systems) lens candidates is retrieved. Our discoveries will be useful for ongoing and planned spectroscopic surveys, such as the Subaru Prime Focus Spectrograph project, to measure lens and source redshifts in order to enable detailed lens modelling.

Psychometric Evaluation of the Multidimensional Assessment of Parenting Scale in LGBTQIA+ Parents.

In LGBTQIA+ adults, 36% are parents, but there are a limited number of parenting scales that have undergone psychometric evaluation in LGBTQIA+ parents. This study assessed the Multidimensional Assessment of Parenting Scale (MAPS) in LGBTQIA+ parents, addressing a gap in parenting scales considering both positive and negative aspects for this group. Our study includes two racially and ethnically diverse national samples of parents (n = 2,299, mean age = 37.05 years, 32.84% LGBTQIA+). We explored measurement invariance between LGBTQIA+ and non-LGBTQIA+ parents. The analysis revealed a modest fit for configural and metric invariance, indicating the MAPS structure and item loadings were consistent across groups, although scalar invariance was only partially supported. Subscales showed good internal consistency for both parent groups. Importantly, following false discovery rate corrections, interactions between LGBTQIA+ status and specific MAPS subscales (supportiveness, physical control) were significantly, but differentially, related to various child psychopathology dimensions, suggesting parenting impacts may differ for LGBTQIA+ families. These findings underscore the importance of including LGBTQIA+ perspectives in parenting research to develop tailored interventions that address their unique strengths and challenges. Acknowledging and supporting the diverse experiences of LGBTQIA+ parents can enhance targeted resources and interventions, contributing to better outcomes for all families.

On the Origin of Quenched but Gas-rich Regions at Kiloparsec Scales in Nearby Galaxies

We use resolved spectroscopy from MaNGA to investigate the significance of both local and global properties of galaxies to the cessation of star formation at kpc scales. Quenched regions are identified from a sample of isolated disk galaxies by a single-parameter criterion D n (4000) - log EW(Hα) >1.6−log2=1.3 , and are divided into gas-rich quenched regions (GRQRs) and gas-poor quenched regions according to the surface density of cold gas (Σgas). Both types of quenched regions tend to be hosted by non-AGN galaxies with relatively high mass (M * ≳ 1010 M ⊙) and red colors (NUV − r ≳ 3), as well as low star formation rate and high central density at fixed mass. They span wide ranges in other properties including structural parameters that are similar to the parent sample, indicating that the conditions responsible for quenching in gas-rich regions are largely independent of the global properties of galaxies. We train random forest classifiers and regressors for predicting quenching in our sample with 15 local/global properties. Σ* is the most important property for quenching, especially for GRQRs. These results strongly indicate the important roles of low-mass hot evolved stars, which are numerous and long-lived in quenched regions and can provide substantial radiation pressure to support the surrounding gas against gravitational collapse. The different feature importance for quenching, as found previously by A. F. L. Bluck et al., is partly due to the different definitions of quenched regions, particularly the different requirements on EW(Hα).

Parent and adolescent perspectives on family problems during the COVID‐19 pandemic: Implications for family resilience

AbstractObjectiveTo understand how parents and adolescents perceive the major family problems they faced during a global pandemic, focusing on implications for family resilience.BackgroundFamilies are challenged by the upheaval in contemporary life due to a global health pandemic and unrelenting changes to work, school, civic, and home routines. Family resilience theory guided our understanding of how families perceive and understand the problems they faced during a major disruption in their lives.MethodA diverse sample of parent–adolescent pairs was surveyed at two points in time. Qualitative content analysis was used to analyze open‐ended questions asking about family members' perceptions of the major problems they faced as a family during the pandemic.ResultsMost participants reported a major family problem during the pandemic (e.g., unemployment, online learning, isolation, fear of COVID‐19), with financial issues being the most prevalent problem. Parents were more likely to identify a major family tension, compared with adolescents, who were more likely to say they were unaware of any major family problems.ConclusionParents and adolescents reported substantial family stress and tension, especially around financial strain and social isolation, indicating their heightened awareness of the new risks they were facing. Both parents and adolescents also described a willingness to pull together on behalf of family well‐being and adaptation.ImplicationsSupport mechanisms through public policy and from family life practitioners can help families navigate pandemic‐related stressors, assess adverse events in adolescence, promote new pathways in navigating disrupted routines, and enhance family resilience.

Arabic validation of the parental stress scale (PSS) in a population-based sample of Lebanese parents

ABSTRACT Background Parental stress significantly impacts the well-being of families, and necessitates culturally sensitive tools for its assessment. The Parental Stress Scale, widely used in diverse cultural settings, lacks a validated Arabic version suitable for the Lebanese context, where unique sociopolitical and economic factors might influence parental stress differently. This study aimed to translate, culturally adapt, and validate the scale in Arabic among a Lebanese sample Methods Following the Snowball sampling method, participants (n = 502) were adult Lebanese parents who answered demographic questions and completed the Arabic version of the Parental Stress Scale and the Depression, Anxiety, and Stress Scale-8. Results Confirmatory Factor Analysis showed a two-factor model of the Parental Stress Scale (CFI = 0.956). We found adequate composite reliability for both the ‘Parental Stress’ (ω = 0.91/α = 0.91) and ‘Parental satisfaction’ (ω = 0.94/α = 0.94) subscales. Convergent validity and concurrent validity were demonstrated through positive correlations with measures of depression, anxiety and stress. Our translation of the scale was shown to be invariant across sexes, with fathers scoring significantly higher than mothers. Conclusion Our validated Arabic version of the Parental Stress Scale offers a culturally sensitive instrument for assessing parental stress in Lebanon. This tool enables healthcare providers and researchers to identify stressors affecting Lebanese families, facilitating the development of targeted interventions to support parental mental health.

Genetic analysis of a fetus with Coffin-Siris syndrome 2 due to a novel variant of ARID1A gene

To explore the genetic etiology of a fetus with Coffin-Siris syndrome (CSS). A fetus with abnormal ultrasound findings detected at Luoyang Maternal and Child Health Care Hospital in July 2023 was selected as the study subject. Clinical data were analyzed retrospectively. Whole exome sequencing was carried out on fetal tissue and parental peripheral blood samples, and candidate variant was verified by Sanger sequencing and pathogenicity analysis. This study was approved by the Luoyang Maternal and Child Health Care Hospital (Ethics No. LYFY-YCCZ-2023011). Color Doppler ultrasound at 16+ gestational weeks revealed bilateral ventriculomegaly and cerebellar hypoplasia in the fetus. Trio-WES found that the fetus has harbored a heterozygous c.553C>T (p.Gln185Ter) variant of the ARID1A gene, which was verified by Sanger sequencing to have a de novo origin. Based on the guidelines from the American College of Medical Genetics and Genomics (ACMG), the c.553C>T (p.Gln185Ter) variant of the ARID1A gene was classified as pathogenic (PVS1+PS2_Supporting+PM2_Supporting). The fetus was diagnosed with CSS type 2, and the heterozygous c.553C>T (p.Gln185Ter) variant of the ARID1A gene probably underlay its brain malformations.

Development and validation of the Parental Affection/Warmth Scale (PAWS) in a sample of parents of 2- to 8-year-olds.

Parental warmth is a treatment target of emerging interventions for children with callous-unemotional traits. However, research to date has yet to examine the empirical structure of parental warmth toward young children due to the lack of clinically feasible, psychometrically sound, and comprehensive measures of warmth for this population. To address this knowledge gap, the present study developed and tested the psychometric properties of a self-report measure of parental warmth, the Parental Affection/Warmth Scale (PAWS). A sample of 899 parents of 2- to 8-year-old children (M = 4.77 years, SD = 1.95; 46.1% girls) was recruited online using Amazon's Mechanical Turk and CloudResearch. Exploratory factor analysis identified a novel three-factor structure: Warmth, Toddler-oriented Interaction, and Play-based Interaction, which was validated by a confirmatory factor analysis. However, only the PAWS Warmth subscale functioned consistently with theoretical expectations. PAWS Warmth scores were internally consistent; convergent with existing positive parenting scales; discriminant from negative parenting scales; and concurrent with child empathy, callous-unemotional traits, and conduct problems. Findings have implications for refining treatment targets for interventions focused on enhancing parental warmth. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Holiday or hell? Emotion regulation and memory of depressive symptoms during lockdown.

The ongoing repercussions of the COVID-19 pandemic provide an unparalleled context to examine how distressing events are remembered. Prior theory and research suggest that (a) distress during lockdowns may fade and be remembered as less distressing, or remain salient and be remembered as more distressing, than initially experienced and (b) emotional suppression and cognitive reappraisal may predict these memory biases. We test these possibilities by assessing depressive symptoms and emotion regulation during two lockdowns: at the start of the pandemic (Lockdown 2020) and 17 months later (Lockdown 2021) in a sample of parents with young children (N = 272). We assessed tracking accuracy, directional bias, and projection bias in memory of depressive symptoms in Lockdown 2020, and the moderating role of emotion regulation at the time of encoding (Lockdown 2020) and recall (Lockdown 2021). People experiencing more depressive symptoms later in the pandemic (2021) remembered the start of the pandemic (2020) to involve more depressive symptoms than initially experienced (projection bias). People engaging in greater emotional suppression at recall (2021) were less likely to project their current depressive symptoms onto memory of the prior lockdown (lower projection bias) and remembered feeling lower depressive symptoms than initially experienced (underestimation directional bias). By contrast, people engaging in cognitive reappraisal at recall (2021) remembered feeling greater depressive symptoms than they initially experienced (overestimation directional bias). These unexpected results indicate that emotion regulation may shape memory of emotion during real-life challenges differently than patterns observed in lab-based research and may reflect helpful coping with life events. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

What influences people’s decision to participate in clinical trials? A qualitative interview study with patients and parents of patients diagnosed with primary membranoproliferative glomerulonephritis (MPGN)

Primary membranoproliferative glomerulonephritis (MPGN) is a group of ultra rare kidney disorders associated with complement activation. MPGN often appears in young age and is uncurable. Current treatments have varying efficiency and new clinical trials are underway to identify better and more tailored treatment pathways. We conducted semi-structured digital interviews with an international sample of MPGN patients and parents of MPGN patients to understand how they would make any potential future decision to participate in future clinical trials. Six main factors influenced the decision-making process: the trial design and practical aspects, personal motivation, concerns about participation, expert advice, current state of illness, and family situation. More specifically, patients and parents considered important that participation in clinical trials is compatible with work and family life and that the expected side effects are limited. They would be motivated by the prospect of maintaining or improving their kidney function or if their current condition was poor. Providing comprehensive information about the risks and benefits of participation, co-designing trials in partnership with patients and limiting the burdens associated with participation may positively impact recruitment and adherence rates.

Development and validation of the caregiver-report version of the international grief questionnaire (IGQ-CG): Results from a Ukrainian sample of parents.

The International Grief Questionnaire (IGQ) is a self-report measure of ICD-11 Prolonged Grief Disorder (PGD) in adults. This study sought to develop and validate a caregiver-report version of the IGQ for children and adolescents aged 7-17 years; the IGQ-Caregiver Version (IGQ-CG). 639 parents living in Ukraine provided data on themselves and one child in their household as part of the "The Mental Health of Parents and Children in Ukraine Study: 2023 Follow-up" study. The latent structure of the scale was tested using confirmatory factor analysis (CFA), while convergent validity was assessed through associations with other mental health correlates. Prevalence rates of probable ICD-11 PGD were estimated. CFA results supported a correlated two-factor model ('core' and 'associated' symptoms) and the internal reliability of the scale scores were acceptable. Convergent validity was supported through significant correlations with internalizing symptoms, while contact with the deceased, time since bereavement, and parental PGD were associated with higher scores on the IGQ-CG latent variables. The prevalence of probable ICD-11 PGD was 1.4%, and amongst those with a lifetime bereavement, the conditional rate was 3.2%. The IGQ-CG produces reliable and valid scores for ICD-11 PGD symptoms in children and adolescents as reported by their caregivers.

Supplemental Material for Development and Validation of the Parental Affection/Warmth Scale (PAWS) in a Sample of Parents of 2- to 8-Year-Olds

Supplemental Material for Development and Validation of the Parental Affection/Warmth Scale (PAWS) in a Sample of Parents of 2- to 8-Year-Olds

Parent-child relationship quality and older parents’ cognitive trajectories

This study assesses the bidirectional link between parent-child relationship quality and older parents’ cognitive trajectories over time, with particular attention to potential variations by parents’ gender. Methods: Using a longitudinal, nationally representative sample of parents aged 50 and older from the Health and Retirement Study 2006–2016, the analysis examines three dimensions of the relationship quality between parents and children—contact, support, and strain—in relation to parents’ cognitive function. Parallel latent growth curve models (LGCMs) estimate how baseline relationship quality relates to subsequent change in parents’ cognition and how parents’ baseline cognitive function relates to subsequent change in relationship quality over time. Results: Higher initial levels of relationship strain with children predicts a faster cognitive decline for older parents. Neither initial contact frequency nor initial relationship support is associated with subsequent change in a parent’s cognition, however, good cognitive function predicts a more rapid increase or a slower decline in contact frequency and relationship support over time. No gender difference was found. Conclusion: The results highlight the importance of the “linked lives” of aging parents and their children as well as the potential for bidirectional associations between cognition and family relationships.

Evaluation of Zeolite Composites by IR and NMR Spectroscopy.

In this study, we assessed the quantity, strength, and acidity of zeolite composites comprising Silicalite-1 grown on ZSM-5 crystals using a combination of infrared (IR) and solid-state nuclear magnetic resonance (NMR) spectroscopy. The composites were created through the direct growth of Silicalite-1 crystals on ZSM-5 (P_ZSM-5), either with or without the organic structure-directing agent (OSDA) introduced into the ZSM-5 channels (samples: H_ZSM-5_Sil1 and TPA_ZSM-5_Sil1). The results revealed that Silicalite-1 grew differently when the ZSM-5 core was in the H+ form (empty pores) compared to when the OSDA was still present in the sample. This distinction was evident in the textural properties, with a decrease in the micropore surface area and an increase in the external surface area in the H_ZSM-5_Sil1 compared to the parent sample. The TPA_ZSM-5_Sil1 composite exhibited characteristics similar to the parent zeolite. These findings were further supported by 29Si NMR, which revealed a comparable local order for the parent (P_ZSM-5) and TPA_ZSM-5_Sil1 samples, along with a broadening of the Q4 peak for the H_ZSM-5_Sil1 composite. Additionally, the acid sites were preserved in the TPA_ZSM-5_Sil1 composite, while in the H+-form core, the concentration of Brønsted acid sites significantly decreased. This reduction in isolated Brønsted acid sites was further corroborated by 1H NMR.

The impact of cobalt oxide additions and heat treatment on wollastonite for magnetic applications

Magnetic nanocomposite was prepared using the wet chemical precipitation approach with varying amounts of cobaltous oxide (CoO). The concentrations of CoO were 0.5, 3.5, 6.5, and 9.5 g per 100 % wollastonite composition. Samples were sintered separately at 1000 and 1200 °C. X-ray diffraction analysis (XRD) of the sintered parent sample revealed the formation of wollastonite CaSiO3 and larnite Ca2SiO4, as well as a minor silicon oxide SiO2 phase. In CoO-doped samples, Co-åkermanite Ca2CoSi2O7 and other phases were formed. The XRD and scanning electron microscope SEM confirm the samples' submicron and nanocrystalline microstructure. The Fourier transform infrared spectroscopy (FTIR) and Raman spectra (RS) of investigated samples sintered at 1000 and 1200 °C revealed their bond structure. Both analyses confirmed that incorporating CoO into CaSiO3 significantly improved its vibrational modes, reflecting structural modifications. By increasing the cobalt oxide content from 3.5 to 9.5 wt%, the samples attain the ideal paramagnetic state, as demonstrated by the magnetic hysteresis (M − H) curve, which is linearly reversible. Formation of the Ca2CoSi2O7 significantly alters the magnetic characteristics of the samples, whether through increasing the cobalt oxide concentration up to 9.5 wt% or modifying the sintering temperature. This enables the prepared nonocomposites to be suitable for novel magnetic applications.

Effectiveness of an unguided modular online intervention for highly anxious parents in preventing anxiety in their children: a parallel group randomised controlled trial

Children whose parents have anxiety problems are at increased risk of developing anxiety themselves. Parenting behaviors are a contributing factor to intergenerational transmission. Interventions which seek to limit anxiogenic parenting behaviors have shown potential in reducing anxiety in offspring but are not widely accessible. This prevention trial aimed to establish the effectiveness of an unguided modular online intervention for highly anxious parents in preventing anxiety in their children. A parallel group, block-randomised controlled trial of unblinded participants in a 1:1 ratio was conducted to compare efficacy of the online course compared to a no-intervention control. The intervention comprised 8 modules, of approximately 20min each, and participants progressed through the course at their own pace. The study was conducted entirely online with a self-referred UK-based community sample of parents (child 2-11 years) with substantial anxiety. The primary outcome measure was change in parent-reported child anxiety, as measured by the Spence Children's Anxiety Scale-Parent Report (SCAS-P) or Spence Pre-School Anxiety Scale-Parent Report (Preschool SCAS). Secondary outcomes were child internalising, externalising, and attentional symptoms (Pediatric Symptom Checklist), and parent anxiety (SCARED-Adult). Analyses using complete case analysis following intention to treat principles investigated intervention effects at 6 months (primary analysis) and additionally at 9 to 25-months' follow-up. Trial registration: ClinicalTrials.GovNCT04755933, https://clinicaltrials.gov/ct2/show/NCT04755933. 1811 participants (intervention=900; control=911; 92.7% (1677/1810) female; 85.3% (1535/1800) White-British; 66.8% (1201/1799) university educated). Participant retention (based on primary outcome completion) at T2 (6-months post consent) was 67.6% overall (n=1224) and substantially lower in the intervention arm 57.3% ((516/900) control=77.8% (708/910)). Child anxiety was lower in the intervention group compared to control at 6-month follow-up (adjusted effect size estimate-0.15 (95% CI:-0.23 to-0.08, p<0.001). There was very strong evidence that those in the intervention arm had lowered child anxiety (standardised SCAS score) compared to the control arm, with an effect size (Cohen's d) of-0.16 (95% CI:-0.23 to-0.08, p<0.001). The difference in standardised Spence Child Anxiety Scale score between the arms was-0.15 standard deviations. On the original scales for SCAS-P (0-114) and Preschool SCAS (0-112), this corresponds to a reduction of-2.38 (95% CI:-3.59 to-1.16) and-2.68 (95% CI:-4.05 to-1.31), respectively. No reported harms. A clinically unsupported online intervention designed for parents with high levels of anxiety is effective in reducing anxiety and internalising symptoms in their children, and also anxiety in parents. Given the low resource intensity of this intervention, and the positive effects reported here, these findings suggest it has promise in limiting the intergenerational transmission of severe anxiety. This work was supported by Kavli Trust (grant 38/19).

제주 지역 맞벌이 부모의 일-가정 갈등과 우울의 관계에서 마음챙김의 매개효과

The purpose of this study is to explore the correlations between work-family conflict, depression, and mindfulness among dual-income parents in the Jeju region, as well as to investigate how work-family conflict affects depression through the mediation of mindfulness and the implications of these results. The study targeted 150 dual-income parents residing in Jeju who have children in elementary school or younger. Through a survey conducted with these participants, the correlations between work-family conflict, depression, and mindfulness were examined, and the mediating role of mindfulness in the relationship between work-family conflict and depression was explored. The main findings of the study are as follows. First, work-family conflict and depression showed a positive correlation, while work-family conflict and depression each showed a negative correlation with mindfulness. Second, mindfulness was found to significantly mediate the relationship between work-family conflict and depression. Lastly, when examining the mediating effect by considering the entire sample of dual-income parents and by separating the parents by gender, it was found that mindfulness completely mediated the relationship between work-family conflict and depression in all cases. The implications of these findings and directions for future research were then discussed.

Magneto-fluorescent core–shell Sr0.8La0.2Fe11CuO19 @ CQDs for the detection of metal ions

The fabrication of a sensor based on a core–shell structure of Sr0.8La0.2Fe11CuO19 @ CQDs was effectively achieved through the combination of high quantum yield carbon quantum dots (CQDs) with La-Cu doped M−type strontium hexaferrites (SLFCO HF). The structural, morphological, and spectroscopic information of the as-synthesized samples were characterized through X-ray diffraction (XRD), Raman spectroscopy (RS), Fourier transform infrared (FT-IR), energy dispersive X-ray (EDX), high-resolution transmission electron microscopy (HR-TEM), and UV–Vis-NIR spectroscopy. The magnetic properties were tested using a vibrating sample magnetometer (VSM) and Mössbauer spectroscopy. HR-TEM confirmed the formation of a hexagonal core–shell sample at the nanoscale. Based on photoluminescence (PL) spectra and the CIE chromaticity map, the parent sample and core–shell structure of SLFCO/CQDs were found to have color coordinates corresponding to yellow-green emission. It was found that the core–shell sample has an increased light-absorption capacity, low photogenerated electron-hole recombination, high coercivity, small crystallite size, and showed good sensitivity towards the detection of Zn2+, Cd2+, and K+ ions. A high efficiency in detecting potassium (K+) ions with a limit of detection (LOD) of 15 ppm was observed. Moreover, the distinctive magnetism of CQDs @ SLFCO aided in the collection and recycling of the sensor.