Parental Age Difference Research Articles

Familial factors rather than paternal age contribute to the aetiology of epilepsy.

Whether paternal age associated with offspring's epilepsy risk is a cause of de novo mutation as men age, or just an association due to confounding factors, is still unclear. We performed a population-based, multi-generation and sibling comparison study in Taiwan, which included 2 751 232 singletons born in 2001-17 who were followed until 2020. Of these, 819 371/826 087 with information on paternal/maternal grandparents were selected for multi-generation analyses and 1 748 382 with sibling(s) were selected for sibling comparison. Cox proportional hazard regression was used to estimate the hazard ratio (HR) and 95% confidence interval (CI). In the total cohort, there was an increased risk of epilepsy in individuals with advanced paternal age, e.g. the HR for paternal age ≥50 was1.36 (95% CI: 1.15-1.61) compared with paternal age 25-29, and fathers older than mothers, e.g. the HR for parental age difference ≥15 years was 1.29 (95% CI: 1.16-1.43). When accounting for parental age difference, the association between paternal age and epilepsy in offspring was attenuated (HR for paternal age ≥50 was 1.11, 95% CI: 0.93-1.34). Multi-generation analyses did not support the association of advanced grand-paternal age at childbirth of the parent with offspring's risk of epilepsy. Sibling comparison analyses did not support the association of older paternal age with increased risk of epilepsy (HR was 0.96 for per year increase in paternal age, 95% CI: 0.96-0.97). These results do not support the hypothesis that advanced paternal age is associated with epilepsy in offspring. Instead, familial factors may explain the observed paternal age association with the offspring's risk of epilepsy.

Shifting Parental Age Differences in High‐Income Countries: Insights and Implications

AbstractAge differences within couples are of considerable importance for the power relations between partners. These age differences become particularly relevant when couples transition to having a(nother) child, as such an event often results in a renegotiation of the gendered division of labor. Surprisingly, the literature on female empowerment and fertility postponement has so far paid little attention to parental age differences. This paper makes use of a new data set to present a demographic analysis of trends in parental age differences at childbirth in 15 high‐income countries, covering a period in which all of these countries experienced changes in gender relations and fertility postponement. The general trends in rising mean ages at childbirth have evolved quite similarly among men and women. However, we demonstrate that these similarities hide previously unexplored and highly gendered disparities in parental age differences. Older mothers report much smaller mean parental age differences than younger mothers, and this age pattern among mothers has further polarized over time. By contrast, older fathers report larger parental age differences than younger fathers, while the disparities by age among fathers have not changed much over time. We discuss the relevance of our findings at both the individual and the societal level.

The association between parental age differences and perinatal outcomes.

Are there significant associations existing between parental age differences and adverse perinatal outcomes? Large differences in parental age are associated with adverse perinatal outcomes, particularly with older mothers paired with younger fathers. The association between advanced maternal age and perinatal outcomes is well-documented with women over 35 years showing an increased risk of several adverse outcomes. Other studies have identified potential associations between advanced paternal age and adverse perinatal outcomes. A historical (retrospective) cohort analysis was performed utilizing a multivariable logistic regression model to evaluate the association between varying differences in parental age and adverse perinatal outcomes while controlling for demographic and health-related covariates. Data were compiled from the National Vital Statistics System for 20613704 births between 2012 and 2018. Parental age differences, categorized into eleven 4-year intervals, were stratified by seven maternal age categories and evaluated for their associations with adverse perinatal outcomes. Main outcome measures included low birth weight, very low birth weight, preterm birth, very preterm birth, small size for gestational age, low 5-min appearance, pulse, grimace, activity, and respiration score, congenital defects, and chromosomal anomalies. Increased parental age differences, in either direction, were associated with significant risks for all adverse outcomes, aside from congenital defects, even when controlling for maternal age. Restricting maternal age to the reference range of 25-29 years, infants born to fathers aged 9-12 years younger (n = 3773) had 27% (odds ratio (OR) 1.27, 95% CI, 1.17-1.37) higher odds of having any adverse perinatal outcome. Infants born to fathers aged >16 years older (n = 98555) had 14% (OR 1.14, 95% CI, 1.12-1.16) higher odds of having any adverse perinatal outcome. Data extracted from US birth certificates may be compromised by errors in reporting or documentation. Information regarding the mother's socioeconomic status was estimated using proxy variables and may be susceptible to uncontrolled factors. Use of a pre-compiled dataset may potentially exclude additional maternal comorbidities that could impact perinatal outcomes. Older mothers paired with younger fathers demonstrated the highest risk, even when maternal age was below the threshold of 35 years. For the clinical setting, parental age differences should be considered alongside maternal and paternal age when assessing risks of adverse perinatal outcomes for potential parents. This is particularly relevant for older women with younger male partners as this may exacerbate the impact of advanced maternal age. This research was funded by the NIH Research Fellowship T35 Training Grant. There are no competing interests. N/A.

Paternal age and 13 psychiatric disorders in the offspring: a population-based cohort study of 7 million children in Taiwan.

Although paternal age has been linked to certain psychiatric disorders, the nature of any causal relationship remains elusive. Here, we aimed to comprehensively assess the magnitude of a wide range of offspring's psychiatric risk conferred by paternal age, leveraging a pedigree inferred from covered-insurance relationship (accuracy >98%) in Taiwan's single-payer compulsory insurance program. We also examined whether there is an independent role of paternal age and explored the potential effect of parental age difference. A total cohort of 7,264,788 individuals born between 1980 and 2018 were included; 5,572,232 with sibling(s) were selected for sibling-comparison analyses and 1,368,942 and 1,044,420 children with information of paternal-grandparents and maternal-grandparents, respectively, were selected for multi-generation analyses. Using inpatient/outpatient claims data (1997-2018), we identified schizophrenia, autism, bipolar disorder (BPD), attention deficit-hyperactivity disorder (ADHD), major depressive disorder (MDD), eating disorder (ED), substance use disorder (SUD), mental retardation (MR), tic disorder, obsessive-compulsive disorder (OCD), anxiety, and somatoform disorder. We identified suicides using death certificates. Logistic regression analysis was used to estimate the paternal/maternal/grand-paternal age association with psychiatric risk in the offspring. The total cohort and sibling-comparison cohort resulted in similar estimates. Paternal age had a U-shaped relationship with offspring's MDD, ED, SUD, and anxiety. A very young maternal age (<20 years) was associated with markedly higher risk in offspring's SUD, MR, and suicide. Older paternal age (>25 years) was linearly associated with offspring's schizophrenia, autism, BPD, ADHD, MDD, ED, SUD, MR, OCD, anxiety, and suicide. Older grand-paternal age was linearly associated with offspring's schizophrenia, autism, ADHD, and MR. Dissimilar parental age was positively associated with offspring's ADHD, MDD, SUD, MR, anxiety, and suicide, and negatively associated with offspring's OCD. This comprehensive assessment provides solid evidence for the independent role of paternal age in psychiatric risk in the offspring and clarifies the significance of both early parenthood and delayed paternity.

Association between parental age, brain structure, and behavioral and cognitive problems in children.

To investigate the relation between parental age, and behavioral, cognitive and brain differences in the children. Data with children aged 9-11 of 8709 mothers with parental age 15-45 years were analyzed from the Adolescent Brain Cognitive Development (ABCD) study. A general linear model was used to test the associations of the parental age with brain structure, and behavioral and cognitive problems scores. Behavioral and cognitive problems were greater in the children of the younger mothers, and were associated with lower volumes of cortical regions in the children. There was a linear correlation between the behavioral and cognitive problems scores, and the lower brain volumes (r > 0.6), which was evident when parental age was included as a stratification factor. The regions with lower volume included the anterior cingulate cortex, medial and lateral orbitofrontal cortex and amygdala, parahippocampal gyrus and hippocampus, and temporal lobe (FDR corrected p < 0.01). The lower cortical volumes and areas in the children significantly mediated the association between the parental age and the behavioral and cognitive problems in the children (all p < 10-4). The effects were large, such as the 71.4% higher depressive problems score, and 27.5% higher rule-breaking score, in the children of mothers aged 15-19 than the mothers aged 34-35. Lower parental age is associated with behavioral problems and reduced cognitive performance in the children, and these differences are related to lower volumes and areas of some cortical regions which mediate the effects in the children. The findings are relevant to psychiatric understanding and assessment.

The effects of parental age difference on the offspring sex and fitness of European blackbirds.

BackgroundMany studies of birds have indicated that offspring sex ratios can vary with environmental and parental traits. On the basis of long-term research, we first evaluated the possible influence of parental age difference and brood characteristics on offspring sex and fitness in multi-brooded Blackbirds Turdus merula.MethodologyThe study was conducted in the city-centre Stefan Żeromski Park in Szczecin, NW Poland, where the local population of Blackbirds has been studied since 1996. Data on the offspring sex and fitness were collected in five years, 2005–2007 and 2016–2017. During the breeding season we inspected the study area to locate the pairs’ territories and to track their nests and clutches.ResultsWe found that the overall sex ratio did not differ statistically from 50:50, but that younger females bonded with older mates did tend to produce more sons, probably because of the greater fitness of male descendants. Accordingly, the sons’ breeding success increased with the father’s age, but this relationship was close to non-linear, which may indicate that the transgenerational effect of paternal senescence could negatively affect progeny fitness despite the high-quality of older fathers. Older females mated with younger males produced more daughters, which could have been due to the lesser attractiveness of the males and the mothers’ poorer condition caused by accelerated senescence. We found that neither offspring hatching sequence nor hatching date or clutch sequence were significant for sex determination.ConclusionsWe consider that in our Blackbird population, parental age could make a more significant contribution to shaping offspring sex and reproductive success.

Male\u2013Female Fertility Differentials Across 17 High-Income Countries: Insights From A New Data Resource

Obtaining cross-country comparative perspectives on male fertility has long been difficult, as male fertility is usually less well registered than female fertility. Recent methodological advancements in imputing missing paternal ages at childbirth enable us to provide a new database on male fertility. This new resource covers more than 330 million live births and is based on a consistent and well-tested set of methods. These methods allow us to handle missing information on the paternal age, which is missing for roughly 10% of births. The data resource is made available in the Human Fertility Collection and allows for the first time a comparative perspective on male fertility in high-income countries using high-quality birth register data. We analyze trends in male–female fertility quantum and tempo differentials across 17 high-income countries, dating as back as far as the late 1960s for some countries, and with data available for the majority of countries from the 1980s onward. Using descriptive and counterfactual analysis methods, we find substantial variation both across countries and over time. Related to the quantum we demonstrate that disparities between male and female period fertility rates are driven to a large degree by the interplay of parental age and cohort size differences. For parental age differences at childbirth, we observe a development toward smaller disparities, except in Eastern Europe. This observation fits with expectations based on gender theories. However, variation across countries also seems to be driven by factors other than gender equality.

Maternal reproductive senescence shapes the fitness consequences of the parental age difference in ruffed lemurs.

In humans, pronounced age differences between parents have deleterious fitness consequences. In particular, the number of children is lower when mothers are much older than fathers. However, previous analyses failed to disentangle the influence of differential parental age per se from a direct age effect of each parent. In this study, we analyse the fitness consequences of both parental age and parental age differences on litter size and offspring survival in two closely related species of lemurs living in captivity. As captive lemurs do not choose their reproductive partner, we were able to measure litter size and offspring survival across breeding pairs showing a wide range of parental age differences. However, we demonstrated that the effect of the parental age difference on litter size was fully accounted for by female reproductive senescence because females mating with much younger males were old females. On the other hand, both parental age difference and female reproductive senescence influenced offspring survival. Our results emphasize the importance of teasing apart the effect of parental reproductive senescence when investigating the health and fitness consequences of parental age differences and also provide new insights for conservation programmes of endangered species.

Parental age and risk of epilepsy: A nationwide register-based study.

This study aims to examine the association between maternal age, paternal age, and parental age difference at the time of birth and the risk of epilepsy in the offspring. We carried out a prospective population-based register study of all singletons born in Denmark between 1981 and 2012. Cox regression was used to estimate hazard ratios (HRs) of epilepsy and their corresponding 95% confidence intervals (CIs), adjusted for relevant confounders. We followed 1587897 individuals for a total of ~25million person-years and identified 21797 persons with epilepsy during the study period. An excess risk of epilepsy was found in individuals born to mothers younger than 20years (HR = 1.17, 95% CI = 1.07-1.29) and born to parental couples where paternal age exceeded maternal age by at least 5years. The risk of epilepsy increased with increasing parental age gap and was highest when the father was ≥15years older than the mother (adjusted HR = 1.28, 95% CI = 1.16-1.41). In contrast to maternal age, we found that paternal age did not independently contribute to offspring epilepsy risk, once we accounted for the parental age difference (P=.1418). The observed associations with maternal age and parental age gap were invariant to epilepsy subtypes, but were modified by age of epilepsy onset, with the effect being most pronounced in the first 10years of the child's life. Maternal age and parental age gap, but not paternal age, were associated with the offspring's risk of epilepsy. Our results do not support the hypothesis that de novo mutations associated with advanced paternal age increase the risk of epilepsy in the offspring.

Age difference between parents influences parity and number of sons.

Among couples, women usually prefer slightly older men, and men tend to choose much younger partners. Age difference between partners has been shown to influence their parity; however, results of previous studies are inconsistent. This study analyzed relationships between husband and wife age difference and their total number of children, and number of daughters and sons in a contemporary, rural Polish population. Demographic and reproductive data were collected from 384 postmenopausal women from rural Poland who were married only once. Regression models were used to evaluate the impact of the age gap between partners on total number of children and on number of daughters and sons. Women's age, age at marriage (as an indicator of reproductive value), and years of education were used in analyzes as potential confounders. There was an inverted U-shape association between parental age difference and number of children and also the number of sons. The highest number of children and sons was observed when men were approximately 6.5 years older than their wives. There was no significant relationship between parental age difference and number of daughters. Age difference between partners is important for reproductive success (with younger wives having higher reproductive potential) and is also related to number of sons. Older husbands might provide more resources for the family, thus facilitating production of well-nourished male offspring. Future research should evaluate not only number of children but also their biological condition, health, and lifetime achievements in relation to the age difference between their parents.

The age of fathers in the USA is rising: an analysis of 168 867 480 births from 1972 to 2015.

How has the mean paternal age in the USA changed over the past 4 decades? The age at which men are fathering children in the USA has been increasing over time, although it varies by race, geographic region and paternal education level. While the rise in mean maternal age and its implications for fertility, birth outcomes and public health have been well documented, little is known about paternal characteristics of births within the USA. A retrospective data analysis of paternal age and reporting patterns for 168 867 480 live births within the USA since 1972 was conducted. All live births within the USA collected through the National Vital Statistics System (NVSS) of the Centers for Disease Control and Prevention (CDC) were evaluated. Inverse probability weighting (IPW) was used to reduce bias due to missing paternal records. Mean paternal age has increased over the past 44 years from 27.4 to 30.9 years. College education and Northeastern birth states were associated with higher paternal age. Racial/ethnic differences were also identified, whereby Asian fathers were the oldest and Black fathers were the youngest. The parental age difference (paternal age minus maternal age) has decreased over the past 44 years. Births to Black and Native American mothers were most often lacking paternal data, implying low paternal reporting. Paternal reporting was higher for older and more educated women. Although we utilized IPW to reduce the impact of paternal reporting bias, our estimates may still be influenced by the missing data in the NVSS. Paternal age is rising within the USA among all regions, races and education levels. Given the implications for offspring health and demographic patterns, further research on this trend is warranted. No funding was received for this study and there are no competing interests. N/A.

Opposite differential risks for autism and schizophrenia based on maternal age, paternal age, and parental age differences

Effects of maternal and paternal age on offspring autism and schizophrenia risks have been studied for over three decades, but inconsistent risks have often been found, precluding well-informed speculation on why these age-related risks might exist. To help clarify this situation we analysed a massive single population sample from Denmark including the full spectrum of autistic and schizophrenic disorders (eliminating between-study confounding), used up to 30 follow-up years, controlled for over 20 potentially confounding factors and interpret the ultimate causation of the observed risk patterns using generally accepted principles of parent-offspring conflict and life-history theory. We evaluated the effects of paternal age, maternal age and parental age difference on offspring mental disorders and found consistently similar risk patterns for related disorders and markedly different patterns between autistic and schizophrenic disorders. Older fathers and mothers both conferred increased risk for autistic but not schizophrenic disorders, but autism risk was reduced in younger parents and offspring of younger mothers had increased risk for many schizophrenic disorders. Risk for most disorders also increased when parents were more dissimilarly aged. Monotonically increasing autism risk is consistent with mutation accumulation as fathers' age, but this explanation is invalid for schizophrenic disorders, which were not related to paternal age and were negatively correlated with maternal age. We propose that the observed maternally induced risk patterns ultimately reflect a shifting ancestral life-history trade-off between current and future reproduction, mediated by an initially high but subsequently decreasing tendency to constrain foetal provisioning as women proceed from first to final pregnancy.

Sex ratio at birth: scenario from normal- and high-level natural radiation areas of Kerala coast in south-west India.

Newborns were monitored for congenital malformations in four government hospitals located in high-level (ambient dose >1.5 mGy/year) and normal-level (≤ 1.5 mGy/year) natural radiation areas of Kerala, India, from August 1995 to December 2012. Sex ratio at birth (SRB) among live singleton newborns and among previous children, if any, of their mothers without history of any abortion, stillbirth or twins is reported here. In the absence of environmental stress or selective abortion of females, global average of SRB is about 1050 males to 1000 females. A total of 151,478 singleton, 1031 twins, 12 triplets and 1 quadruplet deliveries were monitored during the study period. Sex ratio among live singleton newborns was 1046 males (95 % CI 1036-1057) for 1000 females (77,153 males:73,730 females) and was comparable to the global average. It was similar in high-level and normal-level radiation areas of Kerala with SRB of 1050 and 1041, respectively. It was consistently more than 1000 and had no association with background radiation levels, maternal and paternal age at birth, parental age difference, gravida status, ethnicity, consanguinity or year of birth. Analysis of SRB of the children of 139,556 women whose reproductive histories were available suggested that couples having male child were likely to opt for more children and this, together with enhanced rate of males at all birth order, was skewing the overall SRB in favour of male children. Though preference for male child was apparent, extreme steps of sex-selective abortion or infanticide were not prevalent.

Spousal Age Differences and Risk of Infant Mortality in Nigeria: A Multi-level Analysis

Background/objectives: Nigeria remains the largest contributor to neonatal mortality in Africa. Nigeria’s neonatal mortality rate is 48/1000 live births. Existing research on the causes of neonatal mortality in Nigeria has placed great emphasis on factors such as diarrhea, malaria, measles and acute respiratory infections, whooping cough, tuberculosis, bronchopneumonia, dirty feeding bottles and utensils, inadequate disposal of household refuse, poor storage of drinking water and household wealth index1-4. However, insufficient attention has been given to parental age-related factors. Understanding the implications of parental age differences for child health can add to our knowledge of the correlates of neonatal mortality and furnish insights to support the design and delivery of interventions to address the problem. To examine the implications of spousal age-related factors for child health outcomes. Methods: Data for this study were drawn from the 2008 Nigeria Demographic and Health Survey. Univariate and multivariate statistical analyses were used to assess the relationship between neonatal mortality and parental age-related contextual factors focusing on maternal and paternal ages, spousal age, sex of child, household wealth index and place of residence. Results: The multivariate logistic regression analyses yielded significantly increased risk of neonatal mortality among neonates of parents with age differences of 15 years or more. Conclusions: Neonates of couples with age differences of less than 15 years die less compared to neonate of spouses with age difference of 15 years and above.

Clinical and parental age characteristics of rare copy number variant burden in patients with schizophrenia.

Copy number variant (CNV) burden, especially for rare deletions, has been associated with risk for schizophrenia as well as phenotypic differences within cognitive and neuroimaging domains. The current study investigated clinical and parental age characteristics of rare CNV burden in patients with schizophrenia. Clinical data was collected for 629 patients with schizophrenia who formed part of a genomewide association study, which included CNV data. Parental age was available for 368 patients. Correlations were calculated between burden scores and positive, negative, and mood symptoms from the Lifetime Diagnostic Psychosis Scale as well as age at onset. Patients were grouped according to number of rare deletions, duplications, or total CNVs and MANOVAs used to investigate differences in clinical and parental age characteristics. Patients with the least number of CNVs had older fathers and larger parental age difference. Patients with no deletions had older mothers and those with five or more deletions had younger mothers. Total deletion, duplication, and CNV burden, as measured by number of base pairs, were not associated with clinical or parental age differences although total rare duplication burden had a negative correlation with positive symptoms that did not survive correction for multiple testing. Likewise, a positive correlation between age at onset and total CNV burden did not survive correction. Rare CNVs are associated with differences in parental age in patients with schizophrenia. No robust clinical differences were identified. However, duplication burden may have a small protective effect against positive symptoms and age at onset may be influenced by total CNV burden. No clinical differences were associated with deletion burden measures.

Parental age and the risk of bipolar disorders

Studies on the association between parental age and bipolar disorder (BPD) are scarce and with inconsistent findings. The aim of this study was to examine the association of parental age and age difference between parents with risk of BPD in offspring. This nested case-control study identified 1,861 cases of individuals with BPD born in Finland during 1983-1998 and diagnosed by the end of 2008, and 3,643 sex- and date of birth-matched controls from nationwide population-based registers. Conditional logistic regression was used to examine the association adjusting for potential confounding due to age of the other parent, parental psychiatric history, educational level, and place of birth. A U-shaped association of unadjusted odds ratios (ORs) for BPD risk was seen in different paternal age categories, with the odds increasing at both ends of the age spectrum. In the adjusted analyses, offspring of fathers aged ≥ 50 years had a 2.8-fold increased odds [OR = 2.84, 95% confidence interval (CI): 1.32-6.12] of BPD as compared to those with fathers aged 30-34 years. The odds were increased 1.3-fold (OR = 1.35, CI: 1.06-1.72) in fathers aged 20-24 years. No significant association was found between maternal age and BPD in the adjusted analyses. Age difference between parents was not associated with BPD. The increased risk of BPD in offspring of the youngest and oldest fathers in the study suggests the involvement of different biological and psychosocial factors at the two ends of the paternal age spectrum. These findings may be significant in the context of advancing parental age in recent times.

Equilibrium population dynamics when mating is by mutual choice based on age

We consider a steady state model of mutual mate choice in which an individual’s mate preferences depend on his/her age, and the preferences are over the ages of prospective mates of the opposite sex. We present a discrete time (and age) model corresponding to successive mating seasons. Males are fertile for m periods (corresponding to ‘age’ i=1 to m) and females for n≤m periods (they have ages j=1 to n), which is all that distinguishes the sexes. Although we can deal with arbitrary preferences, we concentrate on a simple fertility model where the common utility to a male age i and female age j who mate is the number K=min(m−i+1,n−j+1) of future periods of joint fertility. The incoming sex ratio R of age 1 males to age 1 females is given exogenously. In each period individuals are randomly (non assortatively) matched and form a mated couple by mutual consent; otherwise they go into the next period unmated and older. We derive properties of equilibrium threshold acceptance strategies and establish the existence of time-invariant age distributions. Our methods determine the age distribution of couples at marriage (mating) and the population sex ratio (OSR) at equilibrium. Since this can be determined empirically in a population, our model can be used to rule out most systems of age preferences (those not consistent with the observed distribution). This extends earlier models of mutual choice with one dimensional types of Alpern and Reyniers [1999. Strategic mating with homotypic preferences. J. Theor. Biol. 198, 71–88; 2005. Strategic mating with common preferences. J. Theor. Biol. 237, 337–354] where individuals sought, respectively, individuals with similar or high types, but in those models an individual’s type was fixed over time.Under the simple fertility model, at equilibrium the maximum age of an acceptable partner is increasing in the age of the searcher. Our results relate to discussions in the literature regarding optimal parental age differences, age-related mate preferences, and to mate choice in general. We believe our model will be used as a tool in future investigations in these areas.

How many pathways underlie socioeconomic differences in the development of cognition and achievement?

Children whose parents are more highly educated enjoy greater age-linked gains in cognitive abilities and academic achievement. Different researchers have typically focused on different outcomes, and the extent to which parental education relates to multiple child outcomes via a single developmental pathway has received little empirical attention. This issue was examined by applying common factor structural equation models to a large (N=4810) nationally representative sample of kindergarten through 12th grade children, who were measured on 6 distinct cognitive abilities and 5 distinct forms of knowledge and academic achievement. Results indicated that a single pathway accounted for the relations between parental education and age differences in children's cognitive abilities. However, additional unique pathways were necessary to account for the relations between parental education and age differences in academic knowledge and mathematics. These results suggest that while socioeconomic differences are largely manifested in global aspects of cognitive development, they have incremental relations with some forms of academic achievement.

Sociodemographic and meteorological correlates of sudden infant death in Taiwan

This study was designed, using three national datasets including the Taiwan Death Registry, Taiwan Birth Registry, and National Meteorological Dataset, to examine the sociodemographic, geographic and meteorological correlates of sudden infant death syndrome (SIDS). One thousand, six hundred and seventy-one cases of SIDS occurring between 1994 and 2003, and 8355 matched controls were included in this nested case-control study. Over the study period, the annual rate of SIDS declined only slightly, with an average annual rate of 57.9/10(5) . Male infants (adjusted odds ratio [AOR], 1.19; 95% confidence interval [CI]: 1.06-1.33), preterm births (AOR, 1.69; 95%CI: 1.33-2.13), low birthweight (AOR, 2.87; 95%CI: 2.30-3.59), and birth order ≥3 (AOR, 1.62; 95%CI: 1.37-1.92) were the demographic risk factors for SIDS. Additionally, paternal age <25 years (AOR, 1.37; 95%CI: 1.09-1.71), urbanization (AOR, 1.46; 95%CI: 1.20-1.78), lower paternal education (elementary and less; AOR, 1.28; 95%CI: 1.01-1.64), and parental age difference >10 years (AOR, 1.72; 95%CI: 1.24-2.39) were also associated with increased risk of SIDS. It was also noted that daily average temperature ranging from 9.2°C to 14.2°C (AOR, 2.10; 95%CI: 1.67-2.64) was associated with the most increased risk, while temperature ≥26.4°C (AOR 0.60, 0.61) was significantly associated with the most reduced risk. Sociodemographic, geographic and meteorological data can be used to identify families in greater need of early guidance and to promote various prevention measures to avoid the occurrence of SIDS.

Association between maternal age and birth defects of unknown etiology: United States, 1997-2007.

Birth defects affect 3% of babies born, and are one of the leading causes of infant mortality. Both younger and older maternal age may pose increased risks for certain birth defects. This study assessed the relationship between maternal age at the estimated delivery date and the risk for birth defects. Data were obtained from the National Birth Defects Prevention Study, a population-based case-control study including mothers across 10 states. Maternal age was stratified into six categories: <20, 20 to 24, 25 to 29, 30 to 34, 35 to 39, and ≥40 years, and also analyzed as a continuous variable. Logistic regression models adjusted formaternal race/ethnicity, education, body mass index (BMI), folic acid use, smoking, gravidity, and parental age difference were used to estimate adjusted odds ratios (aORs) and 95% confidence intervals (CIs). For maternal age <20 years, associations with total anomalous pulmonary venous return (aOR, 2.3; 95% CI, 1.3-4.0), amniotic band sequence (aOR, 2.4; 95% CI, 1.5-3.8), and gastroschisis (aOR, 6.1; 95% CI, 4.8-8.0) were observed. For the ≥40 year age group, associations with several cardiac defects, esophageal atresia (aOR, 2.9; 95% CI, 1.7-4.9), hypospadias (aOR, 2.0; 95% CI, 1.4-3.0), and craniosynostosis (aOR, 1.6; 95% CI, 1.1-2.4) were observed. Results using maternal age as a continuous variable were consistent with those that used categorized maternal age. Elucidating risk factors specific to women ateither extreme of maternal age may offer prevention opportunities. All women should be made aware of prevention opportunities, such as folic acid supplementation, to reduce the occurrence of birth defects.