The cure of cancer of the lung is primarily a surgical problem, virtually all long-term survivals having had surgically resectable disease. Unfortunately, resection can be undertaken in only about half of those patients (3) who come to thoracotomy; the remainder are incurable because of metastatic or unresectable lesions. During the last decade, a variety of diagnostic tests, including angiography, have been employed to help in the selection of those patients with lung cancer who present no other contraindications for surgery but are incurable by present surgical maneuvers. The use of angiocardiography in the study of pulmonary and mediastinal cancer has been attempted from both the point of view of diagnosis (7, 9) and of prognosis (4). The latter point has been investigated with particular respect to the prediction of resectability (1, 4, 10, 11, 14) of a lesion. It is the purpose of the present report to evaluate the efficacy of angiocardiography in the study of pulmonary cancer. Method The method used is venous angiocardiography, with the introduction of contrast medium into an arm or upper thoracic vein by way of a catheter inserted by a venous cut-down. The injection is made on the same side as the lesion and serves to evaluate the adjacent venous structures. It is performed either manually or with a mechanical injector. Rapid serial exposures record the passage of the medium through the pulmonary circulation, the left heart, and aorta. We have largely used the Elema biplane serialograph. Angiocardiographic Changes The vascular pattern of the lung and mediastinum is frequently altered by malignant intrathoracic disease. In 84 per cent of 250 consecutive proved cases of pulmonary and mediastinal cancer, Steinberg and Finby (12) found variations from normal. With lesions in close proximity to the hilar regions of the lung, this figure approaches 100 per cent, and in this location the problem of resectability is greatest. Angiocardiographic changes suggestive of cancer are mimicked by a sufficient number of nonmalignant conditions that the definitive diagnosis must be established by histologic study. Patterns of alteration will also differ with right and left hilar lesions. Angiocardiographic Criteria of Unresectability: The criteria of inoperability were first defined by Dotter, Steinberg, and Holman (4). We have found them to be of value in the following order: 1. Involvement of the great venous structures of the mediastinum (Fig. 1), the superior vena cava or the innominate veins. 2. Mediastinal mass lesions. Metastatic lymph-node involvement in the right paratracheal region (Fig. 2) means extensive mediastinal disease. 3. Major pulmonary artery involvement close to the hilus (Fig. 2). For the left pulmonary artery, the margin is 1.5 cm., and on the right is at the point of bifurcation of the right pulmonary artery. 4. Involvement of left atrium or of the major pulmonary veins (Fig. 3).
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