Purpose To evaluate the feasibility and efficacy of percutaneous microwave ablation (MWA) under CT guidance in the management of refractory pain in bone and soft tissue tumors in spinal and para-spinal locations. Materials and Methods 10 MWA were performed in 9 adult patients using an Acculis MTA-2 Generator, 4,5GHz with a 17 gauge antenna. Topography of lesions were as follows : 8 bone lesions (thoracic spine : 1, lumbar spine : 3, sacrum : 4) and 2 soft tissue lesions (paraspinal soft tissue). 5 of 8 bone lesions were osteolytic. All 10 ablated lesions were metastases (lung : 5, prostate : 2, leiomyosarcoma : 1, Renal : 1). All procedures were performed with CT guidance under local anesthesia and nitrous oxide. Follow-up was performed either by contrast ultrasound in case of soft tissue lesion or MRI in case of bone lesion. Pain prior procedure, immediately after and at distance was assessed using a VAS pain score. Results Lesion size ranged from 12 mm to 70 mm. Technical success was 100%. Mean ablation time was 4.75 minutes (1-13) with an average of 4.2 cycles per ablation lasting from 30 seconds to 3 minutes with a ablation power ranging from 30 to 160 W. Mean VAS before procedure was 7.11/10. Immediate pain relief was greater than or equal to 50% in 9/10 cases and lasted for an average of 4.85 months (range 0.5-15months). No adverse events occurred during or after procedure Conclusion Percutaneous MWA appears to be a feasible, safe, effective and fast technique for the management of refractory pain in spinal and parspinal tumors. Ablation time appears to be highly reduced compared to radiofrequency ablation.