Paraneoplastic neurologic syndromes consist of a variety of neurologic disorders that include encephalomyelitis, paraneoplastic cerebellar degeneration (PCD), subacute sensory neuronopathy, retinal paraneoplastic syndrome, opsoclonus-myoclonus syndrome, and stiff-person syndrome. Patients who have PCD and gynecologic tumors characteristically have polyclonal IgG antibody (anti-Yo antibody) that reacts only with Purkinje cell cytoplasm and tumor tissue from PCD patients, giving 62- and 34-kDa proteins on Western blots. [1] Unlike Lambert-Eaton myasthenic syndrome, there is no direct evidence that PCD is caused by autoimmune mechanisms. When transferred passively, anti-Yo …