In large-span bridges or high-rise buildings, CFST columns with large width-to-thickness ratio are often adopted, which require proper stiffening measures to improve the mechanical behaviors. This paper presents a comparative study of circular CFST stub columns with different stiffening methods, including longitudinal stiffeners (cross-shaped, T-shaped and ordinary type), additional reinforcement and headed studs. Axial compression tests have been conducted to investigate the effects of different stiffening methods on the failure mode, ultimate strength and ductility of the circular CFST stub columns. Finite element models are established to simulate the columns’ behaviors and conduct parametric studies. Based on test and simulation results, an axial bearing capacity prediction model for circular CFST stub columns stiffened by longitudinal stiffeners is proposed. It is demonstrated that the failure modes of the steel tube and core concrete are changed by the longitudinal stiffeners. The longitudinal steel stiffeners as well as reinforcing cage can effectively improve the axial bearing capacity and ductility of the columns. The latter is more efficient in promoting the bearing capacity while the former is more efficient in improving the ductility and residual strength. A combination of the additional stirrups and the ordinary stiffeners will be a more economical choice. In addition, the proposed formula gives better prediction accuracy compared to the equations in various design codes.